With the identification of novel antibiotics from nature being pivotal in the fight against human pathogenic bacteria, there is an urgent need for effective methodologies for expedited screening of crude extracts. Here we report the development and validation of a simple and dye-free antimicrobial assay in 96-well microplate format, for both determination of IC50 values and high-resolution inhibit

The losses of honey bee colonies and declines of other insect pollinators have been associated with negative effects of pesticides. Honey bees as well as other pollinators are nectar and pollen foragers and thus are exposed to an extensive range of phytochemicals. Understanding the synergistic, additive, and antagonistic effects of plant secondary metabolites and pesticides in honey bees may help

Honey bees are important pollinators and are subject to numerous stressors, such as changing floral resources, parasites, and agrochemical exposure. Pesticide exposure has been linked to the decline in the global honey bee population. We have limited knowledge of the metabolic pathways and synergistic effects of xenobiotics in bees. Quercetin is one of the most abundant phytochemicals in plants an

Worldwide, 463 million people are affected by diabetes of which the majority is diagnosed with Type 2 Diabetes (T2D). T2D can ultimately lead to retinopathy, nephropathy, nerve damage, and amputation of the lower extremities. α-Glucosidase, responsible for converting starch to monosaccharides, is a key therapeutic target for the management of T2D. However, due to substantial side effects of curren

Bradshaw et al. (2021) make a call to action in light of three major crises—biodiversity loss, the sixth mass extinction, and climate disruption. We have no contention with Bradshaw et al.’s diagnosis of the severity of the crises. Yet, their call for scientists to “tell it like it is,” their appeal to political “leaders,” and the great attention they afford to human population growth as a main dri

A series of regioisomeric isosorbide mono-epoxides, as well as diastereomerically pure mono-epoxy derivatives, have been prepared and studied. Anionic ring-opening polymerization of methoxy-capped monomers produced linear polyethers tethered with isosorbide units. These reasonably high molecular weight polymers exhibited glass transition temperatures at around 10-15 °C and thermal stability up to

In most cases, antiretroviral therapy (ART) results in undetectable plasma HIV viral load (VL). Still, up to 25% of ART recipients may have detectable low-level viremia (LLV) of different amplitude and persistence. This thesis explores the impact of LLV during ART on virologic and clinical outcomes. Paper I–III are retrospective analyses based on InfCare HIV, a national quality register for people

Mohsen Rezaee, a high-ranking official of the Islamic Republic in Iran, has admitted that top-secret Iranian nuclear documents were stolen in a raid of a Tehran warehouse by Israeli operatives in 2018—a raid the regime had denied ever occurred. Rezaee is calling for a purge of the Iranian intelligence and counterintelligence community, which could result in Iranian intelligence operatives fleeing

BACKGROUND: The identification of novel predictors of poor outcome may help stratify cardiovascular risk. Aim was to evaluate the individual contribution of blood cell count parameters, as well as their clustering, on the risk of death and cardiovascular events over the long term in the population-based Malmö Diet and Cancer Study cohort.METHODS: In 30,447 individuals (age 57 ± 8 years), we assess

Recently, there has been an increase in apartments with a large number of inhabitants, i.e., high residential density. This is partly due to a housing shortage in general but also increased migration, particularly in suburbs of major cities. This paper specifies issues that might be caused by high residential density by investigating the technical parameters influenced in Swedish apartments that aRecently, there has been an increase in apartments with a large number of inhabitants, i.e., high residential density. This is partly due to a housing shortage in general but also increased migration, particularly in suburbs of major cities. This paper specifies issues that might be caused by high residential density by investigating the technical parameters influenced in Swedish apartments that a

Visualizing dynamic processes over large, three-dimensional fields of view at high speed is essential for many applications in the life sciences. Light-field microscopy (LFM) has emerged as a tool for fast volumetric image acquisition, but its effective throughput and widespread use in biology has been hampered by a computationally demanding and artifact-prone image reconstruction process. Here, w

What are inhabitants’ perceptions and uses of windows in multi-dwelling buildings? This paper reports on a field study that explores daylight, the visual connection to the outside and the role of windows in the home during the day and night. Qualitative interviews were held with 20 participants living in multi-dwelling buildings. The thematic analysis identified two main components as characterist

PURPOSE: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols.METHODS: We present

Downstream processing of ABE fermentation broth is challenging issue. In this work, results of the application of both hydrophobic and hydrophilic commercial membranes during the pervaporation of ABE aqueous mixtures were investigated and presented. Hydrophobic pervaporation experiments were performed using ABE-water mixtures containing 0-5 wt% of organics in feed, using commercial membranes: POMS

This chapter aims to offer insights into the wider implications for the rule of law, including for the EU constitutional order, of the restrictions of migrants’ and asylum-seeker’ rights that follow from systematic noncompliance with the Common European Asylum System (CEAS) by certain Member States. In other words, has the migration and asylum crisis developed into an EU constitutional crisis? The