Covalent inhibitors of Bruton tyrosine kinase (BTK) have transformed the therapy of chronic lymphocytic leukemia (CLL), but continuous therapy has been complicated by the development of resistance. The most common resistance mechanism in patients whose disease progresses on covalent BTK inhibitors (BTKis) is a mutation in the BTK 481 cysteine residue to which the inhibitors bind covalently. Pirtob

Artikeln ger en översikt av den svenska receptionen av Charlotte Brontës Jane Eyre (1847) och hur romanen har översatts till svenska från den första (indirekta) översättningen 1850 fram till vår tid. Förlagshistoriska, såväl som översättningsanalytiska och receptionskritiska aspekter beaktas.This article (in Swedish) outlines and discusses the Swedish reception of Charlotte Brontës Jane Eyre (1847) with a particular focus on the translation of the novel into Swedish. The first (indirect) Swedish translation appeared in 1850, and the novel has since been translated several times.

Background: The work for Swedish home care workers is challenging with a variety of support and healthcare tasks for home care recipients. The aim of our study is to investigate how these tasks relate to workload and health-related quality of life among home care workers in Sweden. We also explore staff preferences concerning work distribution. Methods: A cross-sectional study was conducted in 16

Background: After a series of standardized reporting systems in cytopathology, the Sydney system was recently introduced to address the need for reproducibility and standardization in lymph node cytopathology. Since then, the risk of malignancy for the categories of the Sydney system has been explored by several studies, but no studies have yet examined the interobserver reproducibility of the Syd

1. Migratory species are particularly sensitive to climate change and face inadequate protection across their range. However, the behaviour of species and individual spatiotemporal variation in habitat use during their non-breeding periods are comparatively less well understood than breeding and migratory periods. 2. I combined five years’ worth of GPS tracking data on juvenile Caspian terns wit

QUIC is a UDP-based transport layer protocol developed by Google that boasts lower latency performance than TCP. However, different conclusions have been reported regarding its performance due to variations in targeted applications and experimental setups. This leads to our conclusion that protocol performance evaluation should be heavily dependent on the QoS requirements of the target application

This Massive Open Online Course (MOOC), offered in partnership with online learning provider Coursera, is a free resource for university students who are currently involved in writing assignments or degree projects as well as for students who wish to learn about academic writing in order to prepare for future writing tasks at university. Although the course provides guidance to all student writers

This research explores how blue-green solutions (BGS) take part in various everyday situations in the Augustenborg neighborhood of Malmö, Sweden, where BGS were introduced over twenty years ago to control urban flooding. The research applies a relational perspective, looking at everyday life as something that is contextually formed and given meaning in relation to the socio-materiality of the envi

The association between the consumption of dairy products and risk of CVD has been inconsistent. There is a lack of studies in populations with high intakes of dairy products. We aimed to examine the association between intake of dairy products and risk of incident major adverse coronary events and stroke in the Swedish Malmö Diet and Cancer cohort study. We included 26 190 participants without pr

BACKGROUND: Globally, the number of small-scale miners (SSM) is estimated to be more than 25 million, but it supports the livelihoods of around 100 million individuals. In Tanzania, the number of SSM has increased from an estimated 150,000 in 1987 to ~1.5 million in 2017. The miners are at a high risk of occupational-related health challenges. The study aimed to assess the concentrations of respir

We complete the model-independent analysis of the scaling properties of the differential cross section of elastic proton-proton cross sections, including new TOTEM data published in 2022 at √s = 8 TeV. We separate the signal and background regions with a new gating method. In the signal region, we find that the statistical significance of the Odderon exchange from the combined 7.0 and 8.0 TeV pp d

Cloud Control Systems (CCSs) harness the power of cloud resources to carry out intense computational tasks, however, they face challenges in delivering time-critical control signals due to network and cloud-induced delays. In this paper, we introduce a novel framework, "Punctual Cloud", designed to enhance the timely delivery of control signals in CCS. This framework ensures that control signals a

Purpose in life, which is a central component of the eudaimonic paradigm of well-being, has been sparsely examined in adolescence. This is unfortunate as adolescence is characterised by identity development and is a key period for the onset of mental disorders. To inform future research on well-being and purpose in life in adolescents, we drew factors from several fields of research, including men

The consequences of climate change are becoming increasingly visible.Recent research suggests that people may respond to climate change andits predicted consequences with a specific anxiety. Yet, little is known aboutpotential antecedents of climate anxiety. The current study aimed to understandthe contribution of climate risk perception to climate anxiety, along withnature-connectedness, self-eff

Objective: To examine whether psychological symptoms and cognitive patterns are associated with self-reported pain and pain sensitization in people with hand osteoarthritis (OA). Design: In the Nor-Hand study (n ​= ​300), people with hand OA self-reported psychological symptoms (Hospital Anxiety and Depression Scale), cognitive patterns (Pain catastrophizing Scale and Arthritis Self-Efficacy Scale