A common form of the hyperkinetic movement disorder dystonia is caused by mutations in the gene TOR1A (located within the DYT1 locus), which encodes the ATPase torsinA. The underlying neurobiological mechanisms that result in dystonia are poorly understood, and progress in the field has been hampered by the absence of a dystonia-like phenotype in animal models with genetic modification of Tor1a a.

At present, there are severe limitations to the successful migration and integration of stem cells transplanted into the degenerated retina to restore visual function. This study investigated the potential role of chondroitin sulfate proteoglycans (CSPGs) and microglia in the migration of human Muller glia with neural stem cell characteristics following subretinal injection into the Lister hooded

Cambodia is one of the poorest countries in south-east Asia and is still emerging from the events of the Khmer Rouge reign. It has been suggested that the atrocities experienced by the Cambodian population can explain why Cambodia continues to lag behind its neighbours in economic outcomes. The purpose of this study is to investigate whether there is an association between exposure to past trauma

We report a facile method of preparing novel branched silver nanowire structures such as Y-shaped, K-shaped and other multi-branched nanowires. These branched nanostructures are synthesized by reducing silver nitrate (AgNO3) in polyethylene glycol (PEG) with polyvinglpyrrolidone (PVP) as capping agent. Statistical data indicate that for the "y" typed branched nanowire, the branches grow out from t

This paper concerns thermometric and direct and indirect investigations of the heat produced by the thermogenic dragon lily (Dracunculus vulgaris) and its main pollinating beetle Protaetia (formerly named Potosia) cretica. The experiments were performed on scented and scentless populations at Panormo, Therisos and Lassithi on the North coast of Crete in the springs of 2007 and 2008. D. vulgaris in

The production of events with multiple high transverse momentum particles including charged leptons and jets is measured, using 1.04 fb(-1) of proton-proton collision data recorded by the ATLAS detector during the first half of 2011 at root s = 7 TeV. No excess beyond Standard Model expectations is observed, and upper limits on the fiducial cross sections for non-Standard Model production of these

The aim of this paper is to discuss the ‘Kurdish question’ in Turkey within the framework of the current debates on the ‘death of multiculturalism’. Contra what I would call ‘multikulti-sceptics’, I contend that it is too early to compose an epitaph for multiculturalism, both as practice and as ideology, that there is no binary opposition between a form of rights-based multiculturalism on the one

The purpose of this paper is to show how ideas from game theory and economics may play an important role for decentralized controller design in complex engineering systems. The focus is on coordination through prices and iterative price adjustments using a gradient method. We give a quantitative bound on adjustment rates that is sufficient to guarantee global convergence towards a Nash equilibrium

OBJECTIVE - The purpose of this study was to assess the efficacy of the postload plasma glucose concentration in predicting future risk of type 2 diabetes, compared with prediction models based oil measurement. of the fasting plasma glucose (FPG) concentration. RESEARCH DESIGN AND METHODS - A total of 2,442 subjects from the Botnia Study, who were free Of type 2 diabetes at baseline, received an o

In this paper, we address the dynamic spectrum allocation problem in next generation cellular networks under the coordinated dynamic spectrum access (CDSA) model. Firstly, considering spectrum demands of base stations, we formulate spectrum allocation under physical interference models as a nonlinear optimization problem. Then, we propose a demand-driven dynamic spectrum allocation algorithm by tr

Women with endometriosis often experience gastrointestinal symptoms. Gonadotropin-releasing hormone (GnRH) analogs are used to treat endometriosis; however, some patients develop gastrointestinal dysmotility following this treatment. The aims of the present study were to investigate gastrointestinal symptoms among patients with endometriosis and to examine whether symptoms were associated with men

A large number of photovoltaic systems have been installed in developing countries around the world during numerous projects. The goal is often to improve the quality of life in rural areas often lacking electricity. Many of these installations provide important services such as lighting and charging of various devices. However, when the projects are finished, there is a large risk that maintenanc

The mechanoreceptive lateral line system in fishes detects hydrodynamic stimuli and plays a critical role in many fundamental behaviours, including orientation to water currents and the detection of stationary objects, prey and predators. Interspecific variation in lateral line structure may result from a process of functional adaptation, with the background level of hydrodynamic activity proposed