Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV) patients using tetramer-associated magnetic enrichment to study antigen-specific inexperienced CD8(+) T cells (i.e., tumor or unrelated virus-spe

Due to the He-3 crisis, alternatives to the standard neutron detection techniques are becoming urgent. In addition, the instruments of the European Spallation Source (ESS) require advances in the state of the art of neutron detection. The instruments need detectors with excellent neutron detection efficiency, high rate capabilities and unprecedented spatial resolution. The Macromolecular Crystallo

Recombinant FVIIa (rFVIIa) was developed for treatment of haemophilia patients with inhibitors against FVIII/FIX. The haemostatic efficacy rate of 80-90% including major orthopaedic surgery (dosing of 90-120 mu g/kg every other hour [h] for at least the first 24 h) was achieved in these patients. In a home-treatment setting the efficacy rate of haemostasis in mild-moderate bleedings was 92% (avera

Background Endometrial adenocarcinoma (womb cancer) is a malignant growth of the lining (endometrium) of the womb (uterus). It is distinct from sarcomas (tumours of the uterine muscle). Survival depends the risk of microscopic metastases after surgery. Adjuvant (postoperative) chemotherapy improves survival from some other adenocarcinomas, and there is evidence that endometrial cancer is sensitive

In the truck industry there is a continuous demand to increase the efficiency and to decrease the emissions. To acknowledge both these issues a waste heat recovery system (WHR) is combined with a partially premixed combustion (PPC) engine to deliver an efficient engine system. Over the past decades numerous attempts to increase the thermal efficiency of the diesel engine has been made. One such at

We have simulated interactions between charged surfaces in the presence of oppositely charged polyelectrolytes by coupling perturbations in the isotension ensemble to a free energy variance minimization scheme. For polymeric systems, this method completely outperforms configurationally biased versions of grand canonical simulations. Proper diffusive equilibrium between bulk and slit has been estab

Laser-ablated group 6 metal atoms react with NF3 and PF3 to form the simple lowest energy N MF3 and P=MX3 products, and this investigation has been extended to AsF3. Mo and W atoms react with AsF3 upon excitation by laser ablation or UV irradiation to form stable trigonal As MF3 terminal arsenides. These molecules are identified by comparison of the closely related infrared spectra of the analogou

A search for the production of single-top-quarks in association with missing energy is performed in proton-proton collisions at a centre-of-mass energy of [Formula: see text] with the ATLAS experiment at the large hadron collider using data collected in 2012, corresponding to an integrated luminosity of [Formula: see text] fb[Formula: see text]. In this search, the [Formula: see text] boson from t

Acute myelogenous leukemia (AML) is characterized by the accumulation of immature cells due to disturbed differentiation and proliferation of the myeloid lineage. Genetic alterations affecting transcription factors and receptor tyrosine kinases have been identified in AML and causally linked to the disease. The goal of this review is to address the role of the different genetic alterations in self

There is general consensus that children of women with pre-existing diabetes mellitus (PDM) have an increased risk of malformations and neurodevelopmental problems. Whether this is also true for children of women with gestational diabetes mellitus (GDM) is a matter of debate. This study investigated inpatient hospital care up to 10 y of age of children born to GDM and PDM women as a rough estimate

Context. The Si III] 1892 angstrom intercombination line shows an anomalously high intensity in spectra of the radiation-rich Weigelt blobs in the vicinity of Eta Carinae. The line disappears during the 100 days long spectral events occurring every 5.5 years. Aims. The aim is to investigate whether resonance-enhanced two-photon ionization (RETPI) is a plausible excitation mechanism for the Si III]

Changes in the ward atmosphere of a psychiatric work rehabilitation unit were investigated. Both trainees and staff filled in the Community-Oriented Programs Environment Scale (COPES) before and after a new rehabilitation model was implemented. It was hypothesised that the levels of autonomy and practical orientation would increase from both the trainees' and staff's perspective concerning the rea

Popular Abstract in Swedish Utveckling av en flerdimensionell residual-distributions lösare för Large Eddy Simulation av industriell turbulenta strömningar.This thesis presents the results of the author's research activity to develop a time-space accurate flow-solver for Large Eddy Simulations (LES), based on the Multidimensional Residual Distribution approach. The aim of this work is the attempt to develop a compact high-order algorithm which includes multidimensional flow physics, in hope of creating a better algorithm for LES of turbulent compress