AbstractBackground Mitral regurgitation (MR) has many etiologies; the most common is degenerative disease. If not corrected, severe MR may cause left and right ventricular heart failure. Mitral valve (MV) repair is the gold standard for treatment of MR. All repair techniques include MV annuloplasty, but various techniques are employed to repair the valvular apparatus. The classical technique of le

Background: Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft model. Methods: We compared the effects of imatinib on oxygen levels, vascular morphology and IFP in three experimental tumor models differing in their co

Background and purpose — Previous reports on elbow injuries with concomitant comminute radial head fracture are difficult to interpret, since they include an array of different soft-tissue and bony injuries around the elbow. We focused on Mason-IV fracture dislocations of the elbow and retrospectively reviewed 2 treatment options: radial head resection or replacement with a radial head arthroplast

I denna publikation karakteriseras riskhanteringsprocessen som bestående av 14 olika steg och varje steg beskrivs och diskuteras. Även utvidgade aspekter på riskhanteringsprocessen samt riskhanteringens ekonomiska betydelse behandlas.Dagens moderna samhälle är ett i många avseenden sårbart samhälle till stor del uppbyggt kring försörjningskedjor (supply chains). I dessa hårt integrerade kedjor med

We demonstrate an artificial three-dimensional (3D) electrical active human neuronal network system, by the growth of brain neural progenitors in highly porous low density electrospun poly-ε-caprolactone (PCL) fiber scaffolds. In neuroscience research cell-based assays are important experimental instruments for studying neuronal function in health and disease. Traditional cell culture at 2D-surfac

The main focus of the work presented in this thesis is on experimental studies oflaser acceleration of protons and other positive ions from solid targets. The topic is explored from three different angles: firstly, the development of diagnostics adapted to the ion pulses, secondly, the characterization of the source of the energetic particles and, finally, the application of laser-accelerated prot

Introduction The Göttingen minipig is a promising model for pharmacological safety assessment and for translational research in cardiology. We have examined the main ion currents in cardiomyocytes of the minipig heart. Methods Cardiac cells were isolated from different cardiac regions (endo-, mid- and epicardial left ventricle and right ventricle) from Göttingen minipigs and examined using the who

Den svenska föreningen för tillämpad språkvetenskap (Association Suédoise de Linguistique Appliquée, ASLA) bildades formellt i april 1966 och firade således 50 år som förening under 2016. Jubileumet uppmärksammades på olika sätt under året. I samband med ASLA-symposiet i Uppsala den 21-22 april 2016 hölls ett panelsamtal på temat om tillämpad språkvetenskap då, nu och i framtiden. I den här texten

This thesis makes a contribution the econometrics of panel data with cross-section dependence (CSD). It consists of five self-contained papers. The most popular approach to account for CSD is to attribute the co-movements of observed variables across entities to unobserved common factors and to estimate these factors via simple cross-section averages of the data. The chapters in this thesis invest

PurposeThe purpose is to provide a structured method for prioritising among the diversity of motives and goals of stakeholders involved in city logistics.Design/methodology/approachThe paper is based on a three-year participant observation study in a city logistics project including ten stakeholders. The data relate to the understanding gained during the three years of study and nine semi-structur

Det finns planer på att bygga ett energilager i berget vid Önneslöv nära Dalby i Skåne. Berggrunden utgörs av en del av Romeleåsen och består huvudsakligen av gnejs med inslag av amfibolit och diabasgångar. Området ligger omedelbart söder om Sydstens stora bergtäkt, där det framgår att berget till stora delar är kraftigt uppsprucket med lervittrade zoner av olika storlek. I samband med byggande geThere are plans to build an energy storage in the rock at Önneslöv near Dalby in Skåne. The bedrock is of a part of Romeleåsen and mainly comprises gneiss, with elements of amphibolite and dolerite intrusions. The area is located immediately south of the Sydsten’s large rock quarry, which shows that the rock is mostly heavily fractured with clay weathered zones of different sizes. In connection wi

In the anthropological debate on human rights a new theoretical approach, a search for a middle ground, has been attempted to solve the dilemma of universalism versus cultural relativism. In the human rights discussion in general, and in the anthropological debate in particular, the dichotomy of universalism/relativism is seen as one major obstacle to the implementation. This article takes a criti

Castleman's Disease (CD) is a rare lymphoproliferative disorder accompanied by marked systemic inflammatory response. Morphological diagnosis of CD requires biopsy of the whole of the involved lymph node tissue. Three histologic variants have already been described in CD morphology (hyaline vascular, plasma-cell, and mixed). In this study, we report a case of a multicentric Castleman's disease of

The longitudinal momentum distribution of Be fragments after fragmentation of B and the one-proton removal cross section (σ-1p) in a carbon target were measured at 1440 MeV/u with the fragment separator FRS used as an energy-loss spectrometer. The results show a narrow momentum distribution with a FWHM value of 91 ± 5 MeV/c and a large cross-section, σ-1p = 98 ± 6 mb. Both these results support th

BACKGROUND: Small molecule inhibitors of phosphatidylinositol-3 kinase (PI3K) have been developed as molecular therapy for cancer, but their efficacy in the clinic is modest, hampered by resistance mechanisms.METHODS: We studied the effect of PI3K therapy in patient-derived tumor organotypic cultures (from five patient samples), three glioblastoma (GBM) tumor cell lines, and an intracranial model

Inflammatory mediators present in the tumor milieu may promote cancer progression and are considered promising targets of novel biological therapies. We previously reported that the marine antitumor agent trabectedin, approved in Europe in 2007 for soft tissue sarcomas and in 2009 for ovarian cancer, was able to downmodulate the production of selected cytokines/chemokines in immune cells. Patients

The p73 locus gene has a complex structure encoding a plethora of isoforms. The different DeltaN truncated isoforms of p73 may exert different activities depending on the cellular context. The beta isoform of DeltaNp73 seems to have a particular pattern of action even if its role in cell cycle and mitosis is still under investigation. To gain further knowledge of DeltaNp73beta's function, we inves