Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders.This first part of the t

Cancer immunotherapies activate the immune system to overcome tumor resistance and restore the antitumor immune response, however, excessive activation of the immune system may also affect normal tissues and organs and cause immune-related adverse events (irAEs) of varying severity. Current in vitro assays used for testing and predicting of irAEs induced by immunotherapeutics are associated with s

Trots att informationssäkerhetspolicyer är väsentliga för informationssäkerhetsarbetet visar tidigare forskning att organisationer inte uppdaterar dessa efter behov. Med hjälp av det lånade begreppet responsivitet från organisatorisk agilitetslitteratur, syftar denna studie på att tillhandahålla förståelse för hur organisationer bedriver sitt arbete med att underhålla informationssäkerhetspolicyer

This qualitative study applies to young men between the ages of 18 and 21 who live in community homes (HVB hem), and have an ongoing substance abuse and addiction problem. The focus will be on the motivation and treatment that from the young men's perspective promotes the process of change to start a life without addiction. This activity, which fulfills an incredibly essential function in soci

The present study was a replication report where it investigates suppression-induced forgetting (SIF) using the think/no-think experimental paradigm and the thought avoidance strategy when tested using the same cue (same probe) and novel cue (independent probe) during learning of neutral words. Same probe test has been examined to demonstrate high sensitivity in detecting inhibition via the relati

In recent years, there has been a lot of discussion in Germany about the compatibility of work and family. Politicians have invested greatly in this area, and reforms have repeatedly addressed problems. In particular, the 2007 reform of the "Bundeselterngeld- und Elternzeitgesetz" (Federal Parental Allowance and Parental Leave Act) was intended to promote female employment while also inv

This thesis will explore the role of cryptocurrencies in a market index portfolio. The portfolios of a mix of Bitcoin, Ether and the market indices S&P 500, OMXS30 and VTI will be examined and optimized to maximize the Sharpe ratio. This process is done using the Markowitz Portfolio Theory for portfolios containing one market index and either one or both cryptocurrencies, numerically optimizin

Two-dimensional terahertz strong-field spectroscopy reveals wave-mixing processes up to eighth order in a free-running quantum cascade laser, unravelling its sub-cycle gain dynamics and nonlinearities in a regime of negative absorption.

The study presents a simple and easy to implement method for detection of the evasive action start in traffic interactions. The method is based on comparison of the studied trajectory with a reference set of ‘unhindered’ trajectories, interpreting the start of evasive action as the moment when no more similarities can be found. The suggested algorithm performs well for primary interactions when ro

The COVID-19 pandemic has disrupted our lives and created wide-reaching impacts. Societies worldwide have confronted the crisis with grassroots mobilisation and social resilience. Civil society uncovers injustices by actively participating in the local decentralised pandemic response. This micro-level study provides insight into a long-standing social movement organisation’s framing of the crisis.

Detecting log data anomalies in real-time is useful since it makes it possible to apply logic that corrects the anomalies when they happen. This project presents a method for detecting public transportation bus event log data anomalies in realtime, without having a labeled data set. Initially, each unique bus trip is represented by the event frequencies, a representation that is not suitable for r

Conventional cemented carbide is recommended for machining Ti6Al4V. However, polycrystalline diamond (PCD) and polycrystalline cubic boron nitride (pcBN) also show promise. Demands for higher productivity accelerate diffusional dissolution and chemically driven wear mechanisms in these tool materials. This study investigates active wear mechanisms by studying the interactions between Ti6Al4V and P

This chapter reviews the data on occurrence of cancers that are potentially caused by alcohol drinking (cancers of the upper gastrointestinal and respiratory tracts, and liver cancer) in relation to social class. In order to assess the role of alcohol drinking in the observed social class gradients of these cancers, we have particularly looked for consistency in the gradients of different alcohol-