The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (αCaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduct

Dissolved organic carbon (DOC) plays a key role in linking terrestrial and aquatic carbon cycles. Most of the work on soil and water DOC has been conducted in temperate watersheds. There is still a gap in knowledge on DOC dynamics within the tropics. This study assesses water extractable organic carbon (WEOC) in topsoils and describes the relationship between WEOC and land use/land cover (LULC), s

Optimized biogenic carbon fluxes for Europe wereestimated from high-resolution regional-scale inversions, uti-lizing atmospheric CO2measurements at 16 stations for theyear 2007. Additional sensitivity tests with different data-driven error structures were performed. As the atmosphericnetwork is rather sparse and consequently contains large spa-tial gaps, we use a priori biospheric fluxes to furthe

Nature-based tourism in the fragile Arctic environments is emerging as a major environmental concern, mainly due to extreme seasonality in these locations, the lack of suitable infrastructures and planning, and its interference with fragile ecosystems. In Iceland tourism has increased exponentially during the past decades, causing more environmental impacts on the country's natural recourses. Hiki

Key observational indicators of climate change in the Arctic, most spanning a 47 year period (1971–2017) demonstrate fundamental changes among nine key elements of the Arctic system. We find that, coherent with increasing air temperature, there is an intensification of the hydrological cycle, evident from increases in humidity, precipitation, river discharge, glacier equilibrium line altitude and

We revisit the problem of why stars become red giants. We modify the physics of a standard stellar evolution code in order to determine what does and what does not contribute to a star becoming a red giant. In particular, we have run tests to try to separate the effects of changes in the mean molecular weight and in the energy generation. The implications for why stars become red giants are discus

We make a number of comments on Chebyshev polynomials for general compact subsets of the complex plane. We focus on two aspects: asymptotics of the zeros and explicit Totik–Widom upper bounds on their norms.

Cytotoxic drugs influence the expression of certain genes in cancer cells. Cisplatin has recently been shown to modulate interleukin (IL)-1 and tumor necrosis factor (TNF)-α production in macrophages. In this study, we wanted to investigate whether cisplatin interferes with the IL-2, IL-2 receptor (IL-2R), interferon (IFN)-γ, and TNF-α expression in phytohemagglutin-stimulated human peripheral blo

Importance To our knowledge, there is no consensus regarding when individuals who repeatedly self-harm and are at risk of suicide should be hospitalized. To evaluate a new alternative, we examined the effects of brief admission (BA) to hospital by self-referral.Objectives To determine the effects of BA on inpatient service use and on secondary outcomes of daily life functioning, nonsuicidal self-i

Catchy slogans about tourism’s peace-promoting qualities abound—‘passport to peace’, ‘a vital force for peace’, and ‘the peace industry’, to name but a few. Yet, despite the critical scrutiny of the peace–tourism nexus in recent decades, its historical origins remain unexplored. This article traces the historical roots of the idea that tourism can help advance peace and international understanding

Background: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are rare diseases with a gradual decline in physical health. Adherence to treatment is crucial in these very symptomatic and life threatening diseases. Objective: To describe PAH and CTEPH patients experience of their self-reported medication adherence, beliefs about medicines and informatio

The barium overabundances observed at the surface of barium stars originate from accretion long ago from the wind of a companion AGB star. However, this scenario cannot explain their high eccentricities and short orbital periods that have remained a mystery for decades. We investigate how kicks imparted to the white-dwarf at its birth or the presence of a circumbinary disk can solve this problem.

The typical acoustical treatment in ordinary rooms such as classrooms, offices, conference rooms etc is an absorbing suspended ceiling. Due to the non-uniform distribution of the absorbing material the sound field at steady-state and during sound decay is far from the ideal conditions assumed in the diffuse field theory. Especially during the sound decay, the degeneration of the sound field emphas