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A new animal product free defined medium for 2D and 3D culturing of normal and cancer cells to study cell proliferation and migration as well as dose response to chemical treatment

Cell culturing methods are increasingly used to reduce and replace the use of live animals in biomedical research and chemical toxicity testing. Although live animals are avoided when using cell culturing methods, they often contain animal-derived components of which one of the most commonly used is foetal bovine serum (FBS). FBS is added to cell culture media among other supplements to support ce

Requirements Engineering for Automotive Perception Systems : An Interview Study

Background: Driving automation systems (DAS), including autonomous driving and advanced driver assistance, are an important safety-critical domain. DAS often incorporate perceptions systems that use machine learning (ML) to analyze the vehicle environment. Aims: We explore new or differing requirements engineering (RE) topics and challenges that practitioners experience in this domain. Method: We

Fountain of youth—Targeting autophagy in aging

As our society ages inexorably, geroscience and research focusing on healthy aging is becoming increasingly urgent. Macroautophagy (referred to as autophagy), a highly conserved process of cellular clearance and rejuvenation has attracted much attention due to its universal role in organismal life and death. Growing evidence points to autophagy process as being one of the key players in the determ

Adverse events associated with microsurgial treatment for ruptured intracerebral aneurysms : A prospective nationwide study on subarachnoid haemorrhage in Sweden

Background Adverse events (AEs) or complications may arise secondary to the treatment of aneurysmal subarachnoid haemorrhage (SAH). The aim of this study was to identify AEs associated with microsurgical occlusion of ruptured aneurysms, as well as to analyse their risk factors and impact on functional outcome. Methods Patients with aneurysmal SAH admitted to the neurosurgical centres in Sweden wer

Can your darkness be measured? Analyzing the full and brief version of the Dark Factor of Personality in Swedish

The Dark Factor of Personality (D) measures the latent core of antagonistic traits. The present study evaluated the psychometric properties of the Swedish version of the full (D70) and the brief (D16) versions, concerning structural validity, item information, and convergent validity. An online sample (N = 294) was analyzed using CFA (Maximum Likelihood Estimation), IRT (Graded Response Model) and

Plasma amyloid-β42/40 and apolipoprotein E for amyloid PET pre-screening in secondary prevention trials of Alzheimer's disease

The extent to which newly developed blood-based biomarkers could reduce screening costs in secondary prevention trials of Alzheimer's disease is mostly unexplored. We collected plasma amyloid-β42/40, apolipoprotein E ϵ4 status and amyloid PET at baseline in 181 cognitively unimpaired participants [the age of 72.9 (5.3) years; 61.9% female; education of 11.9 (3.4) years] from the Swedish BioFINDER-

Investigating the overlap and predictive validity between Criterion A and B in the alternative model for personality disorders in DSM-5

The Alternative DSM-5 Model for Personality Disorders (AMPD) consists of level of personality functioning (Criterion A) and maladaptive personality traits (Criterion B). The brief scale versions of these are understudied, while often being used by clinicians and researchers. In this study, we wanted to investigate the overlap and predictive validity of Criterion A and B. Participants (N = 253) wer

Uptake and effectiveness of newer biologic and targeted synthetic disease-modifying antirheumatic drugs in psoriatic arthritis : results from five Nordic biologics registries

Background We aimed to describe the uptake of newer biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in psoriatic arthritis (PsA) in the Nordic countries and to compare their retention and effectiveness. Methods Patients with PsA starting a b/tsDMARD in 2012-2020 in five Nordic rheumatology registers were included. Uptake and patient characteristics were described,

Hyper-velocity stars from globular clusters hosting intermediate-mass black holes

In 1988 Hills proposed that stars can gain velocities above 500 km s−1 if they are in a stellar binary which gets disrupted by a super massive black hole (SMBH). One of the stars would get trapped in an elliptical orbit around the SMBH while the other gets ejected and obtains a relatively high velocity. Normally stars within galaxies have low peculiar velocities but stars ejected with velocities o

A neurophenomenological fMRI study of a spontaneous automatic writer and a hypnotic cohort

Purpose: To evaluate the neurophenomenology of automatic writing (AW) in a spontaneous automatic writer (NN) and four high hypnotizables (HH). Methods: During fMRI, NN and the HH were cued to perform sponta- neous (NN) or induced (HH) AW, and a comparison task of copying complex symbols, and to rate their expe- rience of control and agency. Results: Compared to copying, for all participants AW was

GEDI : A New LiDAR Altimetry to Obtain the Water Levels of More Lakes on the Tibetan Plateau

Remote sensing is an effective means for lake water level monitoring on the Tibetan Plateau (TP). The purpose of this study is to estimate water levels of lakes on the TP using the Global Ecosystem Dynamics Investigation (GEDI) and Cloud and Land Elevation Satellite-2 (ICESat-2), evaluate the performance of ICESat-2 and GEDI in estimating water levels, and analyze the differences of water level ob