Various biomarkers are available to support the diagnosis of neurodegenerative diseases in clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET, which assesses brain amyloid deposition, and 18F-fluorodeoxyglucose (18F-FDG) PET, which assesses glucose metabolism, provide valuable and complementary information. However, uncertainty remains regarding the optimal timepoi

Technical universities is an omnibus concept, which may conceal variations. This is the fundamental assumption of this chapter, which deals with three technical universities in three European countries: KTH in Sweden, DTU in Denmark, and EPFL in Switzerland. Based on an analysis of scientific impact profiles and their alignment with government steering, funding and internal organisation and leader

Urban woodland vegetation provides people with many aesthetic, ecological and psychological benefits, but can also generate problems concerning people's perception of safety. This paper reviews existing knowledge about perceived personal safety in relation to vegetation, particularly woodland vegetation, in urban green spaces such as parks and residential areas. Individual and social factors, but

BACKGROUND: Heart failure (HF) is a common complication to atrial fibrillation (AF), leading to rehospitalization and death. Early identification of patients with AF at risk for HF might improve outcomes. We aimed to derive a score to predict 1-year risk of new-onset HF after an emergency department (ED) visit with AF. METHODS AND RESULTS: The RE-LY AF (Randomized Evaluation of Long-Term Anticoagu

Recurrent neural networks (RNNs) are efficient for classification of sequential data such as speech and audio due to their high precision on tasks. However, power efficiency, the required memory capacity and bandwidth requirements make them less suitable for battery powered devices. In this work, we introduce FLoPAD-GRU: a system on a chip (SoC) for efficient processing of gated recurrent unit (GR

An integrated thermal biosensor array was designed and fabricated for the simultaneous determination of glucose, urea and penicillin. The sensor contains six thin-film thermistors which were fabricated on quartz chip by micromachining and semiconductor technology. This sensor allows the determination of three different analytes nearly simultaneously by serially partitioning a single microchan

Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell carcinoma (SqCC) cases, and 27 355 controls, as well as multiple transcriptome and e

Plastics is a group of materials commonly encountered on a daily basis by many people. They have enabled rapid, low-cost manufacturing of products with complicated geometries and have contributed to the weight reduction of heavy components, especially when produced into a foamed structure. Despite the many advantages of plastics, some drawbacks such as the often fossil-based raw-material and the e

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of TNFi in patients with JIA.

This paper addresses the optimization of structural health monitoring(SHM) before its implementation on the basis of its Value of Information (VoI). The approach for the quantification of the value of SHM builds upon a service life cost assessment and generic structural performance model in conjunction with the observation, i.e. monitoring, of deterioration increments. The structural performance i

Universities and economic development in lagging regions: ‘triple helix’ policy in Wales. Regional Studies. This paper considers the applicability and relevance of triple helix-based policy and theory, in the weaker region context of Wales, where the success of such approaches has been questionable. It calls for a broader appreciation of the roles of universities in weaker regions beyond a narrow

Protein HC, a heterogeneously charged low molecular weight glycoprotein, and its IgA complex were isolated from human plasma and urine. Plasma from individuals with monoclonal IgA populations was used as starting material for the isolation of the protein HC-IgA complex to obtain homogeneous complex populations. Neither low molecular weight protein HC nor its IgA complex in the concentrations 30 an

Book Review

Objective: Parastomal hernia (PH) in association with an ileal conduit is a common complication that is difficult to treat. Mesh reinforcement has been suggested to improve outcomes; either as prophylaxis or for treatment of a parastomal hernia during abdominal wall reconstruction. Patients and methods: A retrospective study was performed in consecutive patients subjected to mesh implantation betw

Miniaturized thermal biosensors based on three different designs have been constructed. Properties relevant to decentralized bioanalysis have been investigated. A short measurement period (30 s per sample) and a broad linear range (0.5 mM to 100 mM for glucose and penicillin-V), using 1 μl sample volume, have been achieved.

Background: Patients presenting with synchronous colorectal liver metastases are increasinglybeing considered for a curative treatment, and the liver-first approach is gaining popularity in thiscontext. However, little is known about the completion rates of the liver-first approach and itseffects on survival.Methods:A systematic review and meta-analysis of liver-first strategy for colorectal liver