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Single nucleotide polymorphism array (SNP-A) analyses are increasingly being introduced in routine genetic diagnostics of acute lymphoblastic leukemia (ALL). Despite this, only few studies that have compared the diagnostic value of SNP-A with conventional chromosome banding have been published. We here report such a comparison of 296 ALL cases, the largest series to date. Only genomic imbalances >

Background: The association between depression and type 2 diabetes is bidirectional. Underlying biological determinants remain elusive. We examined whether a common melatonin receptor 1B gene diabetes risk variant rs10830963 influenced the associations between depressive symptoms and glycaemic traits. Materials: The Prevalence, Prediction and Prevention of Diabetes-Botnia Study participants (n = 4

Non stoichiometric protic ionic liquids (NSPILs) are efficient electrolytes for protic electrochemical devices such as the all-organic proton battery, which has been suggested as a sustainable approach to energy storage. NSPILs contain a mixture of proton donors and acceptors and are ideal for this purpose due to their high proton conductivity, high electrochemical stability, low cost and ease of

This paper argues that everyday food practices reproduce and negotiate power relations of coloniality. The argument developed brings together Quijano’s notion of coloniality and Bourdieu’s writings on distinction, habitus, and taste. Ethnographic data from fieldwork in the “gastronomic capital of Bolivia”, Cochabamba city, brings out the workings of a “habitus of coloniality” in everyday food prac

A set of key performance indicators (KPIs) for manufacturing operation management is introduced in the ISO 22400 standard. However, KPIs are only defined at a high abstraction level and this hampers the standard's practical adoption. In this paper, a framework is introduced in order to solve this weakness. Starting from the analysis of the relevant measurements used in the KPIs’ formulas, a classi

Wildfires are increasingly affecting forest landscapes around the world. In the Bolivian Chiquitania, southern Amazonia, large wildfires during recent droughts have intensified public debate around more systemic solutions to address the possible root causes. While the integration of different forms of fire knowledge is gaining acceptance as an approach to dealing with increasing wildfire risk, lit

Background: Mechanical knee symptoms are often considered important in the decision to perform knee arthroscopy on the suspicion of a meniscal tear. We investigated if presence of a meniscal tear at knee arthroscopy in adults is associated with presence of preoperative self-reported mechanical knee symptoms. Methods: We used data from Knee Arthroscopy Cohort Southern Denmark (KACS). KACS consists

According to a recent conjecture in the literature, earnings have become a poorer proxy for cash flow from operations over time. We find that since 1988, when cash flow statements started to be consistently reported in Compustat, the cash effectiveness of earnings has actually increased for a large sample of US manufacturing firms. This occurs despite the introduction of fair value accounting and According to a recent conjecture in the literature, earnings have become a poorer proxy for cash flow from operations over time. We find that since 1988, when cash flow statements started to be consistently reported in Compustat, the cash effectiveness of earnings has actually increased for a large sample of US manufacturing firms. This occurs despite the introduction of fair value accounting and

According to previous research the investment-cash flow sensitivity has fallen over time to levels approaching zero in the 2000s, prompting some researchers to argue that the sensitivity cannot be a reasonable measure of financing constraints. We show that differences in sensitivities reappear if one sorts firm according to firms’ need for funding (investment rates) and the cost of external fundin

The ETS family transcription factor GABPA is suggested as an oncogenic element, which is further supported by the recent reporting of it as the sole ETS member to activate the mutant TERT promoter in thyroid carcinomas (TC). However, it remains unclear how GABPA contributes to TC pathogenesis. The present study is designed to address this issue. TERT expression was significantly diminished in TERT

Knowledge of infective endocarditis (IE) caused by Streptococcus dysgalactiae (SD) is limited. This study aimed to identify the clinical and microbiological features of SD-caused IE and to investigate any possible synergy between penicillin and gentamicin on SD isolates. Cases of IE 2008–2016 due to SD reported to the Swedish Registry of Infective Endocarditis (SRIE) were identified. Isolates were

A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time–activity curve derived

Digital volume correlation analysis of time-resolved X-ray microtomography scans acquired during in situ triaxial compression of Green River shale cores provided time series of 3-D incremental strain fields that elucidated evolving deformation processes by quantifying microscopic strain localization. With these data, we investigated the impact of mechanical anisotropy on microscopic strain localiz

Each month thousands of people travel across national borders to access assisted reproductive treatments across Europe. The possibility to purchase fertility treatments in a similar way to other products and services has led not only to a clearly defined market place and customer, but has also contributed to scholarly work on critical studies of kinship. To date, however, there has been little res

Enrolments in STEM disciplines at universities are increasing globally, attributed to the greater life opportunities open to students as a result of a STEM education. But while institutional access to STEM programmes is widening, the retention and success of STEM undergraduate students remains a challenge. Pedagogies that support student success are well known; what we know less about is how unive

It is a human fundamental to desire to be valued, loved and respected - to be significant. Social exclusion induce significance loss which elicits a 'quest for significance' - the search for opportunities to re-gain significance. The present article establishes this relation in a laboratory experiment (N = 71, mean age = 28, SD = 10.42, 65% women, 35% men), showing that socially excluded individua