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Short-term outcome in patients treated with cytoreduction and HIPEC compared to conventional colon cancer surgery

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is an extensive procedure with considerable morbidity. Since only few hospitals perform CRS + HIPEC, this might lead to confounded outcomes between hospitals when audited. This study aims to compare outcomes between peritoneally metastasized (PM) colon cancer patients treated with CRS + HIPEC and patients undergoing

Challenging the dogma of colorectal peritoneal metastases as an untreatable condition : Results of a population-based study

PURPOSE: To determine the impact of the implementation of novel systemic regimens and locoregional treatment modalities on survival at population level in colorectal cancer (CRC) patients presenting with peritoneal metastases (PMs).METHODS: All consecutive CRC patients with synchronous PM (<3 months) between 1995 and 2014 were extracted from the Eindhoven area of the Netherlands Cancer Registry. T

Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer

PURPOSE: To confirm the findings from uncontrolled studies that aggressive cytoreduction in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) is superior to standard treatment in patients with peritoneal carcinomatosis of colorectal cancer origin.PATIENTS AND METHODS: Between February 1998 and August 2001, 105 patients were randomly assigned to receive either standard treatment co

Millora 2.0: Redovisning av resultat för 2018–2020

Based on repeated surveys of the vascular plant flora in 120 hectar plots in the province of Scania, southern-most Sweden, and analyses based on species-specific traits and ecological indicator values, it is concluded that significant changes have taken place 2018–2020 but that they probably mostly reflect the effects of the extremely dry and hot summer of 2018. Species richness has increased signBased on repeated surveys of the vascular plant flora in 120 hectar plots in the province of Scania, southern-most Sweden, and analyses based on species-specific traits and ecological indicator values, it is concluded that significant changes have taken place 2018–2020 but that they probably mostly reflect the effects of the extremely dry and hot summer of 2018. Species richness has increased sign

Charged-particle multiplicities in proton–proton collisions at √s=0.9 to 8 TeV

A detailed study of pseudorapidity densities and multiplicity distributions of primary charged particles produced in proton–proton collisions, at s= 0.9, 2.36, 2.76, 7 and 8 TeV, in the pseudorapidity range | η| < 2 , was carried out using the ALICE detector. Measurements were obtained for three event classes: inelastic, non-single diffractive and events with at least one charged particle in the p

Determination of the event collision time with the ALICE detector at the LHC

Particle identification is an important feature of the ALICE detector at the LHC. In particular, for particle identification via the time-of-flight technique, the precise determination of the event collision time represents an important ingredient of the quality of the measurement. In this paper, the different methods used for such a measurement in ALICE by means of the T0 and the TOF detectors ar

Energy dependence of forward-rapidity J / ψ and ψ(2 S) production in pp collisions at the LHC

We present results on transverse momentum (pT) and rapidity (y) differential production cross sections, mean transverse momentum and mean transverse momentum square of inclusive J / ψ and ψ(2 S) at forward rapidity (2.5 < y< 4) as well as ψ(2 S) -to-J / ψ cross section ratios. These quantities are measured in pp collisions at center of mass energies s=5.02 and 13 TeV with the ALICE detector. Both

Production of Σ (1385) ± and Ξ (1530) 0 in p–Pb collisions at √sNN=5.02 TeV

The transverse momentum distributions of the strange and double-strange hyperon resonances (Σ (1385) ±, Ξ (1530) 0) produced in p–Pb collisions at sNN=5.02 TeV were measured in the rapidity range - 0.5 < yCMS< 0 for event classes corresponding to different charged-particle multiplicity densities, ⟨ dNch/dηlab⟩. The mean transverse momentum values are presented as a function of ⟨ dNch/dηlab⟩ , as w

A search for resonances decaying into a Higgs boson and a new particle X in the XH → qqbb final state with the ATLAS detector

A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fb−1 of proton–proton collision data at s=13TeV collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle X is assumed to decay to a pair of light quarks, and the fully hadronic final state XH→qq¯′bb¯ is analysed. The search considers the reg

Prompt and non-prompt J / ψ production and nuclear modification at mid-rapidity in p–Pb collisions at √sNN=5.02 TeV

A measurement of beauty hadron production at mid-rapidity in proton-lead collisions at a nucleon–nucleon centre-of-mass energy sNN=5.02 TeV is presented. The semi-inclusive decay channel of beauty hadrons into J / ψ is considered, where the J / ψ mesons are reconstructed in the dielectron decay channel at mid-rapidity down to transverse momenta of 1.3 GeV/c. The b b ¯ production cross section at m

Fast-neutron-induced fission cross section of Pu 242 measured at the neutron time-of-flight facility nELBE

The fast-neutron-induced fission cross section of Pu242 was measured at the neutron time-of-flight facility nELBE. A parallel-plate fission ionization chamber with novel, homogeneous, large-area Pu242 deposits on Si-wafer backings was used to determine this quantity relative to the IAEA neutron cross-section standard U235(n,f) in the energy range of 0.5 to 10 MeV. The number of target nuclei was d

Interaction effect of sex and onset of Alzheimer’s disease—rates of progression and prognosis.

Objectives: To investigate the interaction effect of sex and early vs. late onset of Alzheimer’s disease (AD) on long-term cognitive and functional outcomes and survival. Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicentre study of clinical practice involving 1,017 participants diagnosed with mild-to-moderate AD at the start of cholinesterase inhibito

A tale of clusters : No resolvable periodicity in the terrestrial impact cratering record

Rampino & Caldeira carry out a circular spectral analysis (CSA) of the terrestrial impact cratering record over the past 260 million years (Ma), and suggest a ∼26 Ma periodicity of impact events. For some of the impacts in that analysis, new accurate and high-precision ('robust'; 2SE < 2 per cent) 40Ar-39Ar ages have recently been published, resulting in significant age shifts. In a CSA of the

Production cross section and decay study of Es 243 and Md 249

In the study of the odd-Z, even-N nuclei Es243 and Md249, performed at the University of Jyväskylä, the fusion-evaporation reactions Au197(Ca48,2n)Es243 and Tl203(Ca48,2n)Md249 have been used for the first time. Fusion-evaporation residues were selected and detected using a gas-filled separator coupled with its focal-plane spectrometer. For Es243, the recoil decay correlation analysis yielded a ha

Peritoneal metastases found in routinely resected specimens after cytoreductive surgery and heated intraperitoneal chemotherapy

Introduction: Peritoneal metastases (PM) originating from colorectal cancer (CRC) and pseudomyxoma peritonei (PMP) can be treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Certain sites in the peritoneal cavity are prone to contain PM and are, therefore, routinely resected. The aim of this study is to investigate the frequency of disease in CRS specime

The impact of postoperative complications following cytoreductive surgery combined with oxaliplatin based heated intraperitoneal chemotherapy

Introduction: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) has become the mainstream treatment for peritoneal metastases of colorectal origin. This extensive treatment is known for its increased morbidity rate. In this study, the impact of postoperative complications on survival was evaluated in a high-volume centre. Patients and method: Between November 2016

School Choice

School districts in the US and around the world are increasingly moving away from traditional neighborhood school assignment, in which pupils attend closest schools to their homes. Instead, they allow families to choose from schools within district boundaries. This creates a market with parental demand over publicly-supplied school seats. More frequently than ever, this market for school seats is

Cancer follow-up supported by patient-reported outcomes in patients undergoing intended curative complex surgery for advanced cancer

Background and aim: Patient activation (PA) and Patient Involvement (PI) are considered elements in good survivorship. We aimed to evaluate the effect of a follow-up supported by electronic patient-reported outcomes (ePRO) on PA and PI. Method: From February 2017 to January 2019, we conducted an explorative interventional study. We included 187 patients followed after intended curative complex sur