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Background: Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Cells are constantly subjected to various types of endogenous and exogenous stressful stimuli, which can cause serious and even permanent damage. The ability of a cell to sense and adapt to environmental alterations is thus vital to maintain tissue homeostasis during development and adult life. Here, we review some of the major phenotypic characteristics of the hostile tumour microenvironment and

Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. The differentiation stage of tumor cells is recognized as an important clinical factor in several malignancies including neuroblastoma. Tumors with an immature

Mating systems and parental care are predicted to coevolve because the former dictates the cost-benefit ratio of the latter by affecting genetic relatedness between adults and offspring. Reptiles show only rudimentary forms of sociality and parental care and, hence, could provide important insights into the early stages of the evolution and maintenance of social systems. The skink genus Egernia ex

A central question in Alzheimer's disease (AD) research is what role β-amyloid peptide (Aβ) plays in synaptic dysfunction. Synaptic activity increases Aβ secretion, potentially inhibiting synapses, but also decreases intraneuronal Aβ, protecting synapses. We now show that levels of secreted Aβ fall with time in culture in neurons of AD-transgenic mice, but not wild-type mice. Moreover, the ability

In Sweden, a large share of public services are organised, produced and delivered by municipalities, large and small, rich and poor. Contextual conditions (size and location) and economic conditions (efficiency and wealth) differ considerably among these service-providing organisations. The question raised in this paper is whether a municipality's economic situation is a direct consequence of the

Syftet med artikeln är att försöka tolka varför Tumme reste en runsten över sin broder Assur vid kanten av Ryssbysjön i Tuna gärde i Småland.

Using a new database that matches patent applications by Swedish residents with demographic information from 1985 to 2007, we examine differences in inventive performance by individuals of foreign and domestic origins, in terms of quantity (probability of patenting, total number of patents per inventor) and quality (forward citations, probability of grant) of patents. We further compare adult and

We present a re-analysis of the Geneva-Copenhagen survey, which benefits from the infrared flux method to improve the accuracy of the derived stellar effective temperatures and uses the latter to build a consistent and improved metallicity scale. Metallicities are calibrated on high-resolution spectroscopy and checked against four open clusters and a moving group, showing excellent consistency. Th

The magnitude squared coherence (MSC) spectrum is an often used frequency-dependent measure for the linear dependency between two stationary processes, and the recent literature contain several contributions on how to form high-resolution data-dependent and adaptive MSC estimators, and on the efficient implementation of such estimators. In this work, we further this development with the presentati

We prove that the product of finitely many Toeplitz operators oil the Hardy space is zero if and only if at least one of the operators is zero. We use some new vector-valued techniques that not only lead to a vector-valued version of this result but also appear to be needed in the scalar case.

The purpose of this doctoral study is to bring a spatial dimension into the research on urban mobilities and connect the spatial dimension to the marginalisation of cyclists in urban space. This is been done by exploring the role of urban bicycling and transport planning. The theoretical frame of space, mobilities and power is used for analysing that role through case studies in two Scandinavian c

Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45-64 years on a strict gluten-free diet for several years were ra

One of the key research and policy problems in innovation studies is the development of tools for understanding and measuring the impact of academic research on society. The paper contributes to resolving this problem by providing a typology that helps us to understand and analyse the roles researchers take on in order to make academic knowledge useful. A key finding is that utility creation is co

A detector with high dynamic range designed for combined small-and wide-angle x-ray scattering experiments has been developed. It allows measurements on single events and reactive systems, such as particle formation in flames and evaporation of levitating drops. The detector consists of 26 channels covering a region from 0.5 degrees to 60 degrees and it provides continuous monitoring of the sample

Background and Purpose: Coagulation factor XI (FXI) has an important role in the propagation and stabilization of a thrombus upon vessel injury. High FXI levels have been implicated in thrombotic diseases including ischemic stroke. The aim of our study was to investigate whether FXI gene (F11) variants are associated with ischemic stroke. Methods: The discovery sample, the Sahlgrenska Academy Stud

Variability in reported histopathology parameters in operated periampullary adenocarcinomas may affect the prognostic weight of the parameters. Standardized axial sectioning produces a higher incidence of involved margins and also seems to produce a lower relative incidence of pancreatic compared with distal bile duct origin and a higher incidence of involved lymph nodes, compared with non-standar

We present calculations of fission properties for heavy elements. The calculations are based on the macroscopic-microscopic finite-range liquid-drop model with a 2002 parameter set. For each nucleus we have calculated the potential energy in three different shape parametrizations: (1) for 5 009 325 different shapes in a five-dimensional deformation space given by the three-quadratic-surface parame