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Measurement of inclusive and leading subjet fragmentation in pp and Pb–Pb collisions at √sNN = 5.02 TeV

This article presents new measurements of the fragmentation properties of jets in both proton–proton (pp) and heavy-ion collisions with the ALICE experiment at the Large Hadron Collider (LHC). We report distributions of the fraction zr of transverse momentum carried by subjets of radius r within jets of radius R. Charged-particle jets are reconstructed at midrapidity using the anti-k T algorithm w

Measurement of the nuclear modification factor of b-jets in 5.02 TeV Pb+Pb collisions with the ATLAS detector

This paper presents a measurement of b-jet production in Pb+Pb and pp collisions at sNN=5.02 TeV with the ATLAS detector at the LHC. The measurement uses 260 pb - 1 of pp collisions collected in 2017 and 1.4 nb - 1 of Pb+Pb collisions collected in 2018. In both collision systems, jets are reconstructed via the anti- kt algorithm. The b-jets are identified from a sample of jets containing muons fro

Overall and Disease-Specific Mortality in Patients With Cushing Disease: A Swedish Nationwide Study

Context: Whether patients with Cushing disease (CD) in remission have increased mortality is still debatable.Objective: To study overall and disease-specific mortality and predictive factors in an unselected nationwide cohort of patients with CD.Design, patients, and methods: A retrospective study of patients diagnosed with CD, identified in the Swedish National Patient Registry between 1987 and 2

Taming Cloud Integrated Systems in the Wild

This thesis unfolds a journey into the realm of cloud integrated systems. More specifically, it explores the transformational role of diverse cloud infrastructure, be it public or private, centralized or edge-based, when integrated into traditional systems. In this transformation, the cloud assumes the vital role of controllers. Inevitably, this shift towards cloud integration also brings into pla

I hjärtat av Tyskland

Efter Tysklands enande är Harz åter en turistmagnet med mycket att erbjuda: vackra städer, fina vyer, historia och mystik. För en skåning som vill jämföra korsvirkeshus är städerna dessutom ett eldorado. Följ med på en resa i en avlägsen släktings fotspår.

Safety and convenience of once-weekly somapacitan in adult GH deficiency: a 26-week randomized, controlled trial

ObjectiveSomapacitan is a reversible albumin-binding growth hormone (GH) derivative, developed for once-weekly administration. This study aimed to evaluate the safety of once-weekly somapacitan vs once-daily Norditropin®. Local tolerability and treatment satisfaction were also assessed.Design26-week randomized, controlled phase 3 safety and tolerability trial in six countries (Nbib2382939).Methods

Increased levels of circulating endostatin are linked to orthostatic hypotension

BackgroundOrthostatic hypotension (OH) occurs when blood pressure regulation fails. The underlying molecular mechanism of OH remain largely unexplored. Endostatin is a biologically active molecule cleaved by matrix metalloproteinases, elastases and cathepsins from collagen XVIII in the extracellular matrix and inhibits angiogenesis. Circulating levels of endostatin have been proposed to be involve

Prevalence and Incidence of Diabetes Mellitus in Adult Patients on Growth Hormone Replacement for Growth Hormone Deficiency: A Surveillance Database Analysis

Context: GH replacement in adult GH-deficient patients may cause insulin resistance, raising concerns of potential increased risk of developing diabetes mellitus (DM).Objective: Our objective was to assess DM prevalence and incidence in the international Hypopituitary Control and Complications Study (HypoCCS) surveillance database.Design and participants: GH-treated patients enrolled into HypoCCS

Futures of the History of the Humanities : An Introduction

Over the last decade, scholarly attention has turned to the humanities’ collective past with renewed energy and sense of purpose. As a result, a new field of research, the history of the humanities, has crystalized and received broad international attention. In this forum, we take a special interest in the question of where the history of the humanities is heading. And where do we want it to go? I

Trajectories of cognitive processing speed and physical disability over 11 years following initiation of a first multiple sclerosis disease-modulating therapy

Background: We analysed the COMparison Between All immunoTherapies for Multiple Sclerosis (NCT03193866), a Swedish nationwide observational study in relapsing-remitting multiple sclerosis (RRMS), to identify trajectories of processing speed and physical disability after disease-modulating therapy (DMT) start. Methods: Using a group-modelling approach, we assessed trajectories of processing speed w

Electro-thermal Models of Power Modules for Stochastic Optimization of Inverters

Stochastic optimization methods are commonly used in the design process of power electronic systems. These require models of crucial parts of the system which are both scalable and computationally efficient. This paper presents thermal models for traction inverter power modules based on scalable chip area that provide high speed of execution and accuracy. The thermal model includes chip-chip inter

Autism Spectrum Disorders in forensic psychiatric investigations–patterns of comorbidity and criminality

Background: There are contradictory research findings regarding whether individuals with Autism Spectrum Disorders (ASDs) are more or less likely to commit crimes. The aims of the current study were to: (1) Describe psychiatric and crime-related characteristics of a large group of offenders with ASD who had undergone a Forensic Psychiatric Investigation (FPI). (2) Identify clinical subgroups among

Political representatives' experiences of child participation in decision-making processes : A qualitative interview study

The aim was to explore political representatives' experiences of child participation in decision-making processes in municipalities. Interviews were conducted with Swedish politicians (n = 7) representing four municipalities. Qualitative content analysis was used to analyse the data. Politicians had experiences in child participation and methods for involving children and young people in the pract

The Bcm rule allows a spinal cord model to learn rhythmic movements

Currently, it is accepted that animal locomotion is controlled by a central pattern generator in the spinal cord. Experiments and models show that rhythm generating neurons and genetically determined network properties could sustain oscillatory output activity suitable for locomotion. However, current central pattern generator models do not explain how a spinal cord circuitry, which has the same b

Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury

Recent advances have uncovered the non-random distribution of 7, 8-dihydro-8-oxoguanine (8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic effects. Its cognate repair protein, 8-oxoguanine DNA glycosylase 1 (OGG1), reads oxidative substrates and participates in transcriptional initiation. When redox signaling is activated in small airway epithelial cells, the DNA r

Miura transformation for the “good” Boussinesq equation

It is well known that each solution of the modified Korteveg–de Vries (mKdV) equation gives rise, via the Miura transformation, to a solution of the Korteveg–de Vries (KdV) equation. In this work, we show that a similar Miura-type transformation exists also for the “good” Boussinesq equation. This transformation maps solutions of a second-order equation to solutions of the fourth-order Boussinesq

The effect of polymer end-group on the formation of styrene - maleic acid lipid particles (SMALPs)

A series of block copolymers comprising styrene and maleic acid (SMA) has been prepared using RAFT polymerisation. RAFT often results in a large hydrophobic alkylthiocarbonylthio end group and this work examines its effect on the solution behaviour of the copolymers. SMA variants with, and without, this end group were synthesised and their behaviour compared with a commercially-available random co

Solid–Liquid Phase Transitions of Triglycerides in Griebenschmalz, Smalec, and Fedt Studied Using 13C Solid-State NMR with Dynamics-Based Spectral Filtering

The consumer satisfaction of lard-based bread spreads depends on a delicate balance between a liquid fat phase, allowing the spread to flow, and solid fat crystals, providing the product with substance sometimes further enhanced by crispy pork cracklings. Here we apply 13C solid-state NMR with dynamics-based spectral filtering to characterize and follow the temperature dependence of the co-existin