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Trait Disinhibition and NoGo Event-Related Potentials in Violent Mentally Disordered Offenders and Healthy Controls

Trait disinhibition may function as a dispositional liability toward maladaptive behaviors relevant in the treatment of mentally disordered offenders (MDOs). Reduced amplitude and prolonged latency of the NoGo N2 and P3 event-related potentials have emerged as promising candidates for transdiagnostic, biobehavioral markers of trait disinhibition, yet no study has specifically investigated these tw

An international multicenter retrospective analysis of patients with extranodal marginal zone lymphoma and histologically confirmed central nervous system and dural involvement

Marginal zone lymphoma of the central nervous system (CNS MZL) is rare. The clinical features, treatment, and prognosis are not well characterized. We performed a multicenter retrospective study of CNS MZL. Twenty-six patients were identified: half with primary and half with secondary CNS involvement. The median age was 59 years (range 26-78), 62% female and 79% with ECOG performance status ≤ 1. T

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8 and Periphilin — contribute to assembly and targeting of the complex remains unknown. Here, we define the biochemical basis of HUSH assembly and find that its modular architecture rese

Dehydrogenation mechanisms of liquid organic hydrogen carriers over Pt, Pd, Rh, and Ni surfaces : Cyclohexane as a model compound

In order to make a better understanding of dehydrogenation mechanisms of liquid organic hydrogen carriers, cyclohexane was selected as a model compound to carry out its decomposition studies over Pt(1 1 1), Pd(1 1 1), Rh(1 1 1), and Ni(1 1 1) surfaces via periodic density functional theory calculations. The adsorption geometries and adsorption energies of reaction intermediates were presented. Sim

The Great Convergence? Gender and Unpaid Work in Europe and the United States

Over the past decades, men's and women's time use in industrialized nations has changed dramatically, suggesting a gender revolution. Women increased their time in paid work and reduced time in unpaid activities, while men increased their time in unpaid work, but not enough to compensate for women's retreat. We investigate developments regarding men's and women's unpaid work across Europe and the

Revealing vibronic coupling in chlorophyll c1 by polarization-controlled 2D electronic spectroscopy

Vibronic coupling between molecules has been recently discussed to play an important role in photosynthetic functions. Furthermore, this type of coupling between electronic states has been suggested to define photophysical properties of chlorophylls, a family of photosynthetic molecules. However, experimental investigation of vibronic coupling presents a major challenge. One subtle way to study vi

Pleiotropic anticoagulant functions of protein S, consequences for the clinical laboratory. Communication from the SSC of the ISTH

Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter-individual variability makes it problematic to establish reliable cut-off values. PS has multiple physiological functions, with only two appearing to have significant anticoagulant properties: the acti

Democracy and human development : issues of conceptualization and measurement

This study attempts to reconcile competing positions in an important debate about the relationship between regime type and human development. We contend that this empirical relationship is contingent upon issues of conceptualization and measurement in democracy. First, the relationship is more likely to be perceived when democracy is measured in a nuanced fashion, taking account of gradations of d

Quality of life and resource utilization-Swedish data from the Care of Late-Stage Parkinsonism (CLaSP) study

Background: Few studies have investigated the health-related quality of life (HRQoL), resource use and costs in patients with late-stage Parkinson's disease (PD), and data from the Swedish setting are scarce. Objectives: First, we analyse the HRQoL in late-stage PD in Sweden. Second, we analyse the resource use and costs per severity level. Third, we analyse the relationship between costs and phys

Crisis and Public Support for the Euro

The Eurozone crisis has meant slow growth, rising unemployment and social unrest. This contribution gauges the impact of these negative developments on European citizens’ opinion about the euro and the EU institutions. Using Eurobarometer surveys, the authors find that, within the Eurozone, the crisis has only marginally lowered support for the euro but has led to a sharp fall in public trust in t

Does Engaging in Data Philanthropy Impact Business Value?

Data philanthropy (DP) is a new but much-lauded phenomenon. Extant DP research has been either conceptual, exploratory, and/or qualitative. The present study seeks to examine the business value of data philanthropy to the donor firm. We use an event study method to analyze stock performance of public firms associated with data philanthropy activities to determine if a link exists. We find signific

Perception of COVID-19 impacts on the construction industry over time

The emergence of COVID-19 has been changing in the world since 2020 and prompted social, cultural, and economic systems to adjust their structures, routines, and processes. The economic aspects of the pandemic appeared soon, and many industries changed their workflow and procedures through a mandatory or recommended quarantine. Knowing the impact of COVID-19 on different areas of construction proj

The role of RNA-binding proteins in the processing of mRNAs produced by carcinogenic papillomaviruses

Human papillomaviruses (HPV) are epitheliotropic DNA tumor viruses that are prevalent in the human population. A subset of the HPVs termed high-risk HPVs (HR-HPVs) are causative agents of anogenital cancers and head-and-neck cancers. Cancer is the result of persistent high-risk HPV infections that have not been cleared by the immune system of the host. These infections are characterized by dysregu

Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study

BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease (IBD) in the European Prospective Investigation into Cancer and Nutrition.METHODS: 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct er

Passing on the torch : Urban governance, mega-event politics and failed olympic bids in Oslo and Stockholm

While the literature on failed Olympic bids has grown recently, not all failed bids have received attention. This article fills some gap in the literature. The aim of the study is to explore why the cities of Oslo and Stockholm – capitals in countries which are scoring high on various democracy indexes - choose to withdraw their Olympics bids. This is explored by drawing upon literature on urban g

Potentially prolonged psychological distress from postponed olympic and paralympic games during COVID-19—career uncertainty in elite athletes

The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the world of sports due to periods of home quarantine, bans against public gatherings, travel restrictions, and a large number of postponed or canceled major sporting events. The literature hitherto is sparse, but early indications display signs of psychological impact on elite athletes due to the pandemic. However, b

Comorbid amyloid-β pathology affects clinical and imaging features in VCD

Introduction: To date, the clinical relevance of comorbid amyloid-β (Aβ) pathology in patients with vascular cognitive disorders (VCD) is largely unknown. Methods: We included 218 VCD patients with available cerebrospinal fluid Aβ42 levels. Patients were divided into Aβ+ mild-VCD (n = 84), Aβ− mild-VCD (n = 68), Aβ+ major-VCD (n = 31), and Aβ− major-VCD (n = 35). We measured depression with the Ge