BACKGROUND AND OBJECTIVES: Follow-up studies of children and young adults born very-to-moderately preterm show persistent and significant lung function deficits. The aim of the study was to determine lung function and airway mechanics in school-aged children born in 2004 to 2007 and extremely preterm (after 22-26 weeks of gestation).METHODS: In a population-based cohort of children born extremely

Introduction Eosinophilic granulomatosis with polyangiitis (EGPA) is a subset of antineutrophil cytoplasmic antibodies (ANCA) associated vasculitis with distinct pathophysiological mechanisms, clinical features and treatment responses. Rituximab is a licensed therapy for granulomatosis with polyangiitis and microscopic polyangiitis but there is limited experience of rituximab in EGPA. Methods EGPA

Flexible and powerful control over network flows is one of the core advantages of Software-Defined Networking (SDN). Flow rules stored in switch network flow tables contain information on packet processing and routing. Flow rules are stored in memory, in a set of data structure rules, and managed by a classifier in flow tables. Network flows are a valuable asset: they contain information about the

Diabetes mellitus is associated with decreased haemodynamic stability and reduced tolerance to hypovolaemia. Compensatory haemodynamic responses during experimental hypovolaemia in type 1 diabetes patients with (DMR+) and without (DMR-) retinopathy as well as healthy controls (C) were studied. Lower body negative pressure created hypovolaemic circulatory stress. Volumetric techniques were used to

This article analyses the three recent Nordic Noir television series Bordertown (Sorjonen) from Finland, Trapped (Ófæro), from Iceland, and the Danish- Swedish The Bridge (Broen/Bron). All series are located on national borderlands, and this article aims to discern the significance of using such borderland settings. Departing from Doreen Massey's emphasis on places as being inherently interlinked

Utomhusbelysning i offentliga miljöer har en viktig roll i en hållbar stadsutveckling. Energieffektiv LED-belysning kan stödja mobilitet i stadsmiljöer och medverka till en ökad tillgänglighet för personer med särskilda behov. Belysningen i föreliggande studie upplevdes ge tillräcklig ljusmängd och jämnt ljus, och det gick att se bra i belysningen. Trots att LED-belysningen ökade möjligheterna til

Type 1 diabetes is a complex disease where numerous genes are involved in the pathogenesis. Genes that account for approximately 50% of the familial clustering of the disease are located within or in the vicinity of the HLA complex on chromosome 6. Some DRB1, DQA1 and DQB1 genes are known to be involved, in addition to as yet unidentified HLA-linked genes. The DR4-DQ8 and DR3-DQ2 haplotypes are kn

BACKGROUND: Glutamic acid decarboxylase-65 (GAD65), the enzyme that catalyzes the formation of gamma-aminobutyric acid (GABA), is the major autoantigen in both type 1 (insulin-dependent) diabetes and stiff-man syndrome (SMS). The observation that GAD65 autoantibodies may be present for years before the clinical onset of diabetes raises the question of when GAD65 is available to initiate an immune

Writing well is central to academic success, but writing skills are not always taughtexplicitly. This is especially problematic in international, interdisciplinaryprograms where such skills help students from diverse backgrounds to develop ashared vocabulary of writing and tools to decode their new academic context.We tackled this issue by hiring and training peer writing tutors to encourage newst

Introduction: The purpose of this study was to investigate potential associations between body composition and current smoking in young healthy women from high-risk families. Cigarette smoke contains >7000 chemicals of which 69 are established carcinogens and smoke also acts as an aromatase inhibitor. Smoking is now recognized as a carcinogen for the breast and influences both risk and prognosis.

Fossil fuel companies’ existence is incompatible with the planet’s survival, says Bill McKibben Paris 2015 will be one step along the line, not the thing that solves all the problemsWe now have solutions we didn’t have 25 years ago, we should deploy them with all possible speed

AIMS: To evaluate the effect of adding insulin to sulphonylurea (SU) and the effect of SU withdrawal on glycaemic control in Type 2 diabetic patients who failed on treatment with SU alone.METHOD: One hundred and seventy-five patients were included in a placebo-controlled multicentre study. During phase I (4 months), premixed insulin was added to glibenclamide therapy; during phase II (1-4 months,

Despite the fact that the observed gradient in water content among the Galilean satellites is globally consistent with a formation in a circum-Jovian disk on both sides of the snowline, the mechanisms that led to a low water mass fraction in Europa (∼8%) are not yet understood. Here, we present new modeling results of solids transport in the circum-Jovian disk accounting for aerodynamic drag, turb