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Dose and plasma concentration of galantamine in Alzheimer's disease - clinical application

Introduction: Patients with Alzheimer's disease (AD) are currently treated with cholinesterase inhibitors, such as galantamine, without actual knowledge of its concentration in plasma. Our objective was to analyse potential relationships between galantamine concentration, galantamine dose, socio-demographic characteristics, body weight, body mass index (BMI), and treatment response. Methods: Eight

The History, Development, and Realisation of Medical Radiation Physics Education in Sweden

This paper describes the history of Swedish medical radiation physics education and gives details of the core curriculum of today’s 5-year specialised medical radiation physicist programme, which fulfils the need to educate clinical physicists with versatile basic knowledge and skills who are well prepared for professional life in all sub-areas of medical radiation physics and radiation protection

Output feedback distributed model predictive control with inherent robustness properties

We consider robust output feedback distributed model predictive control (DMPC). The proposed controller is based on the results in [8] in which nominal stability and feasibility was proven for a DMPC-formulation without terminal constraint set or terminal cost in the optimization. We extend these results to show robust stability under state feedback as well as output feedback when dynamics and mea

Depressive symptoms, atherosclerotic burden and cerebral blood flow disturbances in a cohort of octogenarian men from a general population

Background: The aim of this study was to examine in elderly men a relationship between depressive symptoms, peripheral vascular disease and cerebral blood flow (CBF). Methods: Population-based cohort study started with an examination of 809 men at age 55, followed by the first (age 68ys) and second follow up (age 82ys). 128 survivors were examined at age 82 with Tc-99m-HMPAO-SPECT to estimate CBF,

Voronoi-based three-dimensional polygonal finite elements for electromechanical problems

Abstract in UndeterminedWe discuss the combination of a hybrid finite element approach and three-dimensional Voronoi-based mesh discretisations for electromechanically coupled problems. The fluxes, i.e. the stresses and electric displacements, are defined within the volume of the polygonal finite elements, whereas the displacements and electric potential are approximated on the boundaries of the e

From Competitive to Cooperative Resource Management for Cyber-Physical Systems

This thesis presents models and methods for feedback-based resource management for cyber-physical systems. Common for the scenarios considered are severe resource constraints, uncertain and time-varying conditions and the goal of enabling flexibility in systems design rather than restricting it. A brief survey on reservation-based scheduling, an important enabling technology for this thesis, is pr

Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimi

Current status of transplantation and organ donation in the Balkans-could it be improved through the South-eastern European health Network (SEEHN) initiative?

Organ donation and transplantation activity in the majority of Balkan countries (Albania, Bosnia and Herzegovina, Croatia, Macedonia, Moldova, Montenegro, Serbia, Romania and Bulgaria) are lagging far behind international averages. Inadequate financial resources, unclear regional data and lack of governmental infrastructure are some of the issues which should be recognized to draw attention and pr

Energy dependence of the transverse momentum distributions of charged particles in pp collisions measured by ALICE

Differential cross sections of charged particles in inelastic pp collisions as a function of pT have been measured at root s = 0.9, 2.76 and 7 TeV at the LHC. The pT spectra are compared to NLO-pQCD calculations. Though the differential cross section for an individual root s cannot be described by NLO-pQCD, the relative increase of cross section with root s is in agreement with NLO-pQCD. Based on

Stream flow velocity alters submerged macrophyte morphology and cascading interactions among associated invertebrate and periphyton assemblages

Submerged macrophytes play a key role in the functioning of stream ecosystems since they strongly affect the biological and physical environment of the habitat. On the other hand, flow velocity may affect growth and establishment of submerged macrophytes in streams and rivers. However, little attention has been paid to the morphological responses of submerged macrophytes to different stream flows

Maternity care options influence readmission of newborns

Aim: To analyse morbidity and mortality in healthy newborn infants in relation to various routines of post-natal follow-up. Design: cross-sectional study. Setting: maternity care in Sweden. Population: healthy infants born at term between 1999 and 2002 (n = 197 898). Methods: Assessment of post-natal follow-up routines after uncomplicated childbirth in 48 hospitals and data collected from the Swed

Evaluation of Macular Structure and Function by OCT and Electrophysiology in Patients with Vitelliform Macular Dystrophy Due to Mutations in BEST1

PURPOSE. To analyze retinal structure and function in vitelliform macular dystrophy (VMD) due to mutations in BEST1. METHODS. Patients from five Swedish and four Danish families were examined with electrooculography (EOG), full-field electroretinography (ffERG), multifocal ERG (mfERG), optical coherence tomography (OCT), and fundus autofluorescence photography (FAF). Genetic analysis of the BEST1

The Swedish CArdioPulmonary BioImage Study: objectives and design.

Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of

Probing cellulose amphiphilicity

Cellulose dissolution and regeneration is an increasingly active research field due to the direct relevance for numerous production processes and applications. The problem is not trivial since cellulose solvents are of remarkably different nature and thus the understanding of the subtle balance between the different interactions involved becomes difficult but crucial. There is a current discussion