Gene transfer is a promising drug delivery method of advanced therapeutic entities for Parkinson's disease. One advantage over conventional therapies, such as peripheral delivery of the dopamine pre-cursor L-DOPA, is site-specific expression of proteins with regenerative, disease-modifying and potentially neuroprotective capacity. Several clinical trials have been performed to test the capacity of

Identifying the molecular basis of environmentally induced phenotypic variation presents exciting opportunities for furthering our understanding of how ecological processes and the environment can shape the phenotype. Urban and rural environments present free-living organisms with different challenges and opportunities, which have marked consequences for the phenotype, yet little is known about re

We build a 3d face shape model, including inter- and intra-shape variations, derive the analytical jacobian of its resulting 2d rendered image, and show example of its fitting performance with light, pose, id, expression and texture variations.

BACKGROUND: Rice husks (RH) are agricultural residues with abundant storage of cellulose and hemicellulose, making them a potential feedstock for polyhydroxyalkanoate (PHA) production. In this study, optimization of pretreatment with alkali under various conditions was performed before enzymatic hydrolysis using Celluclast 1.5 L (EC 3.2.1.4) and Novozyme 188 (EC 3.2.1.21). The hydrolysate was fed

The Swedish model of industrial relations is distinguished by a high degree of self-regulation with roots around the turn of the century 1900. Under the threat of state regulation, the labour market parties in the 1930s, and again in the late 1990s, found they had a common interest in self-regulation. The 1938 Saltsjöbaden Agreement between the blue-collar confederation LO and the employer confede

Pericles is usually viewed as a great statesman and clever leader of the Athenians. In the mid-fifth century BC, however, he seems to have been in serious political trouble and may well have been in danger of losing a political struggle against his opponent Kimon. The fact that his incentives changed considerably at this point in time seems to have escaped attention in the literature. In contrast,

Protein homeostasis, or proteostasis, is required for mitochondrial function, but its role in cancer is controversial. Here we show that transgenic mice expressing the mitochondrial chaperone TNFR-associated protein 1 (TRAP1) in the prostate develop epithelial hyperplasia and cellular atypia. When examined on a Pten(+/-) background, a common alteration in human prostate cancer, TRAP1 transgenic mi

DNA-dependent protein kinase (DNA-PK) plays a key role in the repair of DNA double-strand breaks (DSBs) that are probably the most deleterious form of DNA damage. Inhibition of DNA-PK has been considered as an attractive approach to decrease resistance to therapeutically induced DNA DSBs. Ionizing radiation (IR) and doxorubicin, which induce DSBs, are used in the treatment of breast cancer. We det

Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes producing fusion proteins with altered properties. In the case of myxoid liposarcoma (MLS) tumors, the causative abnormality is a fusion between the CHOP transcription factor and the FUS or EWS genes. CHOP belongs to and is a negative regulator of the large CAAT/enhancer binding protein family whos

Ingvar Kärnefelt fann sitt naturintresse i Göteborg under uppväxtåren, inte minst i den yttre skärgården. Här berättar han om intresset för Alperna och dess ängar.

An extraction method for mixed-linkage β-glucan from oat and barley was developed in order to minimize the effect of extraction on the β-glucan structure. β-Glucan were characterized in terms of molecular size and molar mass distributions using asymmetric flow fieldflow fractionation (AF4) coupled to multiangle light scattering (MALS), differential refractive index (dRI) and fluorescence (FL) dete

Soil organisms have an important role in aboveground community dynamics and ecosystem functioning in terrestrial ecosystems. However, most studies have considered soil biota as a black box or focussed on specific groups, whereas little is known about entire soil networks. Here we show that during the course of nature restoration on abandoned arable land a compositional shift in soil biota, precede

Partially Premixed Combustion (PPC) is a promising combustion concept for future IC engines. However, controllability of PPC is still a challenge and needs more investigation. The scope of the present study is to investigate the ignition sensitivity of PPC to the injection timing at different injection pressures. To better understand this, high-speed shadowgraphy is used to visualize fuel injectio

Aims and objectives: To describe what nursing and rehabilitation staff know and do with regard to urinary incontinence and risk of urinary incontinence in patients 65 years or older undergoing hip surgery. Background: Urinary incontinence is a common but often neglected issue for older people. Despite the existence of evidence-based guidelines on how to assess, manage and prevent urinary incontine