We demonstrate an artificial three-dimensional (3D) electrical active human neuronal network system, by the growth of brain neural progenitors in highly porous low density electrospun poly-ε-caprolactone (PCL) fiber scaffolds. In neuroscience research cell-based assays are important experimental instruments for studying neuronal function in health and disease. Traditional cell culture at 2D-surfac

The main focus of the work presented in this thesis is on experimental studies oflaser acceleration of protons and other positive ions from solid targets. The topic is explored from three different angles: firstly, the development of diagnostics adapted to the ion pulses, secondly, the characterization of the source of the energetic particles and, finally, the application of laser-accelerated prot

PurposeThe purpose is to provide a structured method for prioritising among the diversity of motives and goals of stakeholders involved in city logistics.Design/methodology/approachThe paper is based on a three-year participant observation study in a city logistics project including ten stakeholders. The data relate to the understanding gained during the three years of study and nine semi-structur

Inflammatory mediators present in the tumor milieu may promote cancer progression and are considered promising targets of novel biological therapies. We previously reported that the marine antitumor agent trabectedin, approved in Europe in 2007 for soft tissue sarcomas and in 2009 for ovarian cancer, was able to downmodulate the production of selected cytokines/chemokines in immune cells. Patients

The Ukrainian shield hosts two Palaeoproterozoic anorthosite-mangerite-charnockite-granite (AMCG) complexes (the Korosten and Korsun-Novomyrhorod complexes) that intruded Palaeoproterozoic continental crust in north-western and central parts of the shield, respectively. We report results of U-Pb zircon and baddeleyite dating of 16 samples from the Korosten plutonic complex (KPC), and 6 samples fro

Background: There is consensus that dementia is the most burdensome disease for modern societies. Few cost-of-illness studies examined the complexity of Alzheimer's disease (AD) burden, considering at the same time health and social care, cash allowances, informal care, and out-of-pocket expenditure by families. Methods: This is a comprehensive cost-of-illness study based on the baseline data from

Background. To inform their health decisions, patients may seek narratives describing other patients' evaluations of their treatment experiences. Narratives can provide anti-treatment or pro-treatment evaluative meaning that low-numerate patients may especially struggle to derive from statistical information. Here, we examined whether anti-vaccine (v. pro-vaccine) narratives had relatively stronge

In this paper the problem of automatic mapmaking is treated. The principles are discussed and details are given for a simple version of the problem where an autonomous vehicle moves on a factory floor. A semi-automatic approach has been developed, analyzed, simulated and nally tested for a commercial laser guided vehicle. The vehicle is equipped with a laser scanner that measures the direction but

Pain is a major health issue for each affected individual and has a large impact on health costs. Most of our knowledge about this defensive system rely on data from different animal experiments. There is an obvious need for a translational pain model allowing comparisons between experimental animals and humans. UVB irradiation of skin has been introduced as a valid translational pain model and th

Den svenska föreningen för tillämpad språkvetenskap (Association Suédoise de Linguistique Appliquée, ASLA) bildades formellt i april 1966 och firade således 50 år som förening under 2016. Jubileumet uppmärksammades på olika sätt under året. I samband med ASLA-symposiet i Uppsala den 21-22 april 2016 hölls ett panelsamtal på temat om tillämpad språkvetenskap då, nu och i framtiden. I den här texten

In the anthropological debate on human rights a new theoretical approach, a search for a middle ground, has been attempted to solve the dilemma of universalism versus cultural relativism. In the human rights discussion in general, and in the anthropological debate in particular, the dichotomy of universalism/relativism is seen as one major obstacle to the implementation. This article takes a criti

The p73 locus gene has a complex structure encoding a plethora of isoforms. The different DeltaN truncated isoforms of p73 may exert different activities depending on the cellular context. The beta isoform of DeltaNp73 seems to have a particular pattern of action even if its role in cell cycle and mitosis is still under investigation. To gain further knowledge of DeltaNp73beta's function, we inves

This article reports an analysis of the first detailed chemistry direct numerical simulation (DNS) of a high Karlovitz number laboratory premixed flame. The DNS results are first compared with those from laser-based diagnostics with good agreement. The subsequent analysis focuses on a detailed investigation of the flame area, its local thickness and their rates of change in isosurface following re

Objectives: The paper describes recruitment results and characteristics of the UP-TECH clinical trial sample, including level of care services use, informal caregiver burden and its determinants.Methods: UP-TECH is designed to test innovative care solutions for community-dwelling patients with moderate stage Alzheimer's disease and their caregivers in Italy. Four hundred and fifty patient-caregive