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The human microbiome can produce metabolites that modulate insulin signaling. Type 2 diabetes patients have increased circulating concentrations of the microbially produced histidine metabolite, imidazole propionate (ImP) and administration of ImP in mice resulted in impaired glucose tolerance. Interestingly, the fecal microbiota of the patients had increased capacity to produce ImP, which is medi

RQ20 (Research Quality Evaluation 2020), the major research quality evaluation at Lund University, is part of a cycle of assessments done in the last two decades. RQ20 differs from the former evaluations in that it assesses the preconditions for research quality and the potential areas of elevation in all parts of the University, rather than being an evaluation of research quality. The many dimens

INTRODUCTION: Complement-mediated atypical hemolytic uremic syndrome (aHUS) is an ultra-rare renal disease primarily caused by genetic alterations in complement proteins. The genetic work-up required for confirmation of diagnosis is complicated and not always logistically accessible. The aim of the present study was to apply a diagnostic scheme compliant with the ACMG guidelines to investigate the

Biografi över tonsättaren Wilhelm Gnosspelius (1809−1887).

Compton scattering is generally neglected in diffraction experiments because the incoherent radiation it generates does not give rise to interference effects and therefore is negligible at Bragg peaks. However, as the scattering volume is reduced, the difference between the Rayleigh (coherent) and Compton (incoherent) contributions at Bragg peaks diminishes and the incoherent part may become subst

The aim was to develop and evaluate a preparatory information booklet for adult patients undergoing magnetic resonance imaging (MRI). The booklet was developed based on pertinent literature and clinical experience. After ethical approval, it was then evaluated qualitatively in 10 people who had received the booklet before their first ever MRI scan. All patients expressed the need for written prepa

Two-dimensional (2D) culturing of cancer cells has been indispensable for the development of anti-cancer drugs. Drug development, however, is lengthy and costly with a high attrition rate, calling to mind that 2D culturing does not mimic the three-dimensional (3D) tumour microenvironment in vivo. Thus, began the development of 3D culture models for cancer research. We have constructed a 3D 96-well

This paper is a comparison of water vapor resistance (Ret) measured using the Permetest skin model and Tore sweating thermal manikin, i.e. 2D versus 3D methods; and to study the relationship between them. Three materials and five air gap distances were used for the measurement between these two devices, the test conditions in the climatic chambers were set up according to the ISO standard of each

Across Asia, the international school scene has experienced marketisation and corporatisation. A consequence is that many wealthier families–outside of expatriate communities–view international schools as a desirable choice, and they seek ways to enrol their children in international schools. States have responded to this situation through policies that manage the boundaries between public or nati

This chapter examines the aesthetic of the sinograph in the French-language novels, calligraphic works, and picture books by two first-generation Chinese migrant writers and artists in France, François Cheng and Shan Sa. It begins with an illustration of Cheng's and Shan's 'Chinese' calligraphic works (accompanied by the artists' French texts) (Et le Souffle devient signe: Portrait d’une âme à l’e

Francophone Chinese writers Dai Sijie and François Cheng are both first-generation migrants in France, whose French-language literary works have received the highest French institutional recognitions (from the Prix Femina to the Grand Prix de la francophonie de l'Académie française). Existing scholarship on the impact of their native Chinese language on these writers' French texts focuses almost e

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies and is known for its high resistance and low response to treatment. Tumor immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Karyopherin alpha 2 (KPNA2), a member of the nuclear transporter family, is elevated in multiple human cancers and accelerates carcinogenesis. Howeve