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Introduction: COPD has complex etiologies involving both genetic and environmental determinants. Among genetic determinants, the most recognized is a severe PiZZ (Glu342Lys) inherited alpha1-antitrypsin deficiency (AATD). Nonetheless, AATD patients present a heterogeneous clinical evolution, which has not been completely explained by sociodemographic or clinical factors. Here we performed the gene

Purpose: Transcriptional pathway activity and the molecular subtypes of breast cancer metastases have been shown to significantly influence patient postrelapse survival. Here, we further determine the relevance of clinically employed gene signatures in the advanced breast cancer (ABC) setting. Experimental Design: Sufficient RNA for expression profiling was obtained from distant metastatic or inop

Background and Purpose. Low-grade gliomas show infiltrative growth in white matter tracts. Diffusion tensor tractography can noninvasively assess white matter tracts. The aim was to preoperatively assess tumor growth in white matter tracts using quantitative MR tractography (3T). The hypothesis was that suspected infiltrated tracts would have altered diffusional properties in infiltrated tract seg

Background: Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availability of dosimetry-based MRT in clinical practice and research studies. The aim of this study was to assess the current practice of MRT and dosimetry across European countries. Metho

Background - Previous reports have implicated multiple genetic loci associated with AF, but the contributions of genome-wide variation to AF susceptibility have not been quantified. Methods and Results - We assessed the contribution of genome-wide single-nucleotide polymorphism variation to AF risk (single-nucleotide polymorphism heritability, h2 g) using data from 120 286 unrelated individuals of

Purpose: In 90Y microsphere radioembolization (RE), accurate post-therapy imaging-based dosimetry is important for establishing absorbed dose versus outcome relationships for developing future treatment planning strategies. Additionally, accurately assessing microsphere distributions is important because of concerns for unexpected activity deposition outside the liver. Quantitative 90Y imaging by

Purpose: This study explored whether complement factor 3 (C3) in plasma is associated with incidence of diabetes in a population-based cohort. We also identified genetic variants related to C3 and explored whether C3 and diabetes share common genetic determinants.Methods: C3 was analyzed in plasma from 4368 nondiabetic subjects, 46 to 68 years old, from the Malmö Diet and Cancer Study. Incidence o

PURPOSE. To determine if corneal subbasal nerve plexus (SBP) parameters derived from widearea depth-corrected mosaic images are associated with type 2 diabetes. METHODS. One hundred sixty-three mosaics were produced from eyes of 82 subjects by laserscanning in vivo confocal microscopy (IVCM). Subjects were of the same age, without (43 subjects) or with type 2 diabetes (39 subjects). Mosaic corneal

För ett stort antal elever i ungdoms- och vuxenutbildning gäller det attta sig an den komplexa uppgiften att både utveckla kunskaper i olikaämnen och att erövra ett helt nytt språk: svenska. Språktillägnandetbehöver understödjas på allra bästa sätt för att nå en nivå som kan mötade höga språkliga krav som ställs inom utbildning, yrkesliv och samhälle.Detta ställer i sin tur stora krav på andrasprå

Importance: Evidence is lacking regarding the consequences of antibiotic use in early life and the risk of certain autoimmune diseases.Objective: To test the association between early-life antibiotic use and islet or celiac disease (CD) autoimmunity in genetically at-risk children prospectively followed up for type 1 diabetes (T1D) or CD.Design, Setting, and Participants: HLA-genotyped newborns fr

OBJECTIVES: To analyze perinatal outcomes after maternal use of attention-deficit/ hyperactivity disorder (ADHD) medication during pregnancy. METHODS: The study included singletons born between 2006 and 2014 in Sweden. Data on prescription drug use, pregnancies, deliveries, and the newborn infants' health were obtained from the Swedish Medical Birth Register, the Prescribed Drug Register, and the

Background - Aortic valvular stenosis (AS) is the most common cause of cardiac valvular replacement surgery. During the last century, the pathogenesis of AS has undergone transitions in developed countries, from rheumatic heart disease to a degenerative calcific pathogenesis. Although a familial component has been described for a subset of cases with a bicuspid valve, data are limited on the overa

Supplemental Instruction is one of the most successful programmes of peer-assisted study in existence. Numerous studies show that SI attendance correlates with student achievement, regardless of the level of knowledge of the student prior to commencing their studies. The present study, from Humanities at Lund University, Sweden, outlines a method for gauging the effect of SI on soft values such as

Kapitlet beskriver en övning lämplig för studenter i kurser om socialt entreprenörskap. Övningen tillämpar tekniker för kommunikation för att erhålla donationer från olika intressenter.

En av utmaningarna för lärare är att känna igen språkfel som en del av språkutvecklingen. Eftersom normen i klassrummet ofta är språklig korrekthet kan det vara svårt att urskilja utvecklingen. Synen på inlärarspråket som ett eget språk snarare än en sämre variant av målspråket samt kunskap om typiska drag i inlärarspråket ökar möjligheterna att se den utveckling som faktiskt sker hos eleverna, vi

Boken presenterar på ett populärt sätt forskningsresultat från arkeologi, geologi och historieforskning. Det geografiska perspektivet omfattar Skåne under förhistorisk tid men därefter Kävlinge socken. Uppgiften om ett slag på Kävlingebro omkring 1020 föranledde en arkeologisk undersökning vilket presenteras. Lantbrukets utveckling utgör en viktig tråd i boken. Rikt illustrerad.