Complement is crucial to the immune response, but dysregulation of the system causes inflammatory disease. Complement is activated by three pathways: classical, lectin, and alternative. The classical and lectin pathways are initiated by the C1r/C1s (classical) and MASP-1/MASP-2 (lectin) proteases. Given the role of complement in disease, there is a requirement for inhibitors to control the initiat

How the ability to acclimate will impact individual performance and ecological interactions under climate change remains poorly understood. Theory predicts that the benefit an organism can gain from acclimating depends on the rate at which temperatures change relative to the time it takes to induce beneficial acclimation. Here, we present a conceptual model showing how slower seasonal changes unde

Contemporary disaster risk management requires the exchange and integration of risk information across societal sectors and administrative borders. However, differences in how risk is described can be an obstacle to making sense of the material. This paper focuses on the challenge of aggregating risk assessments from multiple stakeholders and aims to establish the characteristics of risk descripti

B cell receptor signaling and downstream NF-κB activity are crucial for the maturation and functionality of all major B cell subsets, yet the molecular players in these signaling events are not fully understood. Here we use several genetically modified mouse models to demonstrate that expression of the multifunctional BRCT (BRCA1 C-terminal) domain-containing PTIP (Pax transactivation domain-inter

Growth of III-V semiconductor nanowires is generally assisted by a liquid particle in order to get a highly anisotropic crystallization. The thermodynamic stability of the particle is therefore of importance for control and understanding of the nanowire growth process. In this report we explore the particle stability by manipulating its properties, specifically its surface tension and volume, by a

Bakgrund: Sverige är besparat från direkt inblandning i krig sedan 200 år.Under samma tid har svenska läkare vid flera tillfällen medverkat i utländskakonflikter. Samlade studier om dessa individer har hittills saknats.Frågeställning: Vad har motiverat svenska läkare att delta i utländskakonflikters militärsjukvård? Vad har de uträttat och hur har de tolkat sinaerfarenheter?Material: Studien inklu

Introduction: Several thrombin-generation tests are available, but few have been directly compared. Our primary aim was to investigate the correlation of two thrombin generation tests, thrombin generation assay-calibrated automated thrombogram (TGA-CAT) and INNOVANCE ETP, to factor VIII levels (FVIII:C) in a group of patients with hemophilia A. The secondary aim was to investigate inter-laboratory

This thesis considers statistical methods for non-stationary signals, specifically stochastic modelling, inference on the model parameters and optimal spectral estimation. The models are based on Silverman’s definition of Locally Stationary Processes (LSPs). In all the contributions, an example of a biomedical application of the proposed method is provided. In the first two papers, the methods are

I nordsamisk er transitivitetsveksling alltid morfologisk markert – det vil si at to verb som sammen utgjør et transitivitetspar, aldri er morfologisk like. Det morfologiske forholdet mellom slike verb varierer derimot en hel del. Interessant nok viser det seg at de morfologiske mønstra vi kan observere i nordsamisketransitivitetspar, i noen tilfeller ser ut til å antyde en annen struktur enn den

This study investigated the influence of five El Niño-Southern Oscillation (ENSO) types on rainy-season precipitation in China: central Pacific warming (CPW), eastern Pacific cooling (EPC), eastern Pacific warming (EPW), conventional ENSO and ENSO Modoki. The multi-scale moving t test was applied to determine the onset and withdrawal of rainy season. Results showed that the precipitation anomaly c

Bats navigate the dark using echolocation. Echolocation is enhanced by external ears, but external ears increase the projected frontal area and reduce the streamlining of the animal. External ears are thus expected to compromise flight efficiency, but research suggests that very large ears may mitigate the cost by producing aerodynamic lift. Here we compare quantitative aerodynamic measures of fli