Triple-negative breast cancer (TNB) has poor prognosis and moreover patients with TNB do not benefit from established targeted drugs with endocrine therapy or trastuzumab. The aim of the study was to analyze the prevalence of candidate biomarkers in tumors from patients with TNB. Tissue microarrays were prepared from primary tumors from premenopausal breast cancer patients (500/564) randomized to

Substandard newborn care has been identified as a major contributor to the estimated annual 4 million neonatal deaths and 1 million fresh stillbirths. Low-income countries, including Nigeria account for more than 95% of all cases. A cross-sectional comparative study utilising non-participant observation methods was used to study perinatal care at two maternity centres in Lagos, Nigeria. Data on 63

swedish folk-dance, folk-dance groups, folk-culture

Abstract not available.

ABSTRACT: muscle cells (VSMCs) through activation of endothelin type A (ETA) and type B (ETB) receptors. The extracellular signal-regulated kinase 1 and 2 (ERK1/2) mitogen-activated protein kinases (MAPK) are involved in ET-1-induced VSMC contraction and proliferation. This study was designed to investigate the ETA and ETB receptor intracellular signaling in human VSMCs and used phosphorylation (a

Kommentar till kampanjen för sänkt moms på e-böcker.

In maintenance treatment for opiate addiction, buprenorphine can be administered less frequently than daily due to its long half-life.

Popular Abstract in Swedish Från skärva till kärl fokuserar på ett arkeologiskt massmaterial, en materialkategori som är särskilt vanlig framför andra bland de arkeologiska fynden. Skärvor är fragment av keramiska kärl och analysen kommer att färdas från det lilla till det något större - från skärva till kärl. I centrum återfinns de kärl som varit i bruk i Uppsala från 1100-talets mitt till 1700-tAbstract From Sherd to Pot. A Contribution to the History of Everyday Life in Uppsala tackles the question: how is the culturally created reality produced, fixed, and changed, and how can this be related to the social structure as a whole? The hypothesis is that changes in society result in new cultural patterns which can be read in objects. The work consists of three main parts, an extensive summ

AIMS/HYPOTHESIS: About 35% of individuals with type 2 diabetes develop persistent albuminuria, lose renal function, and are at increased risk for microvascular complications like diabetic nephropathy. Recent genome-wide association studies have identified the uromodulin locus (UMOD), encoding the most common protein in human urine to be associated with hypertension and also with chronic kidney dis

Hur ska en högre utbildning i säkerhetsledning se ut? Ska den ha utgångspunkt i teknik och problemlösning, ekonomi och management, kriminologi och beteendevetenskap eller kanske juridik? Här är del två i artikelserien om professionaliseringen av säkerhetsarbetet. Nu handlar det om möjligheter och utmaningar för en akademisk utbildning kring säkerhetsledning.

Treatment options for HIV patients have dramatically improved since the introduction of efficacious antiretroviral combination therapy more than a decade ago. Treatment regimens have been simplified with fewer pills and fewer daily dosages. Fosamprenavir is a protease inhibitor with a rather long half-life which makes it a candidate for once-daily use. Once-daily dosage of ritonavir-boosted fosamp

Mesenteric venous thrombus may be an incidental finding during imaging studies and asymptomatic patients are treated conservatively or with anticoagulant therapy only. Patients with symptomatic acute thrombosis causing bowel ischemia require urgent treatment, which frequently includes extensive surgery. Interventional treatment may be an alternative.

Amplification and overexpression of PPM1D (protein phosphatase magnesium-dependent 1 delta) has been observed in various cancer cell lines and primary tumors and has also been associated with cancers of poor prognosis. In addition to the negative feedback regulation of p38-p53 signaling, PPM1D inhibits other tumor suppressor activities and is involved in the control of DNA damage and repair pathwa

One regression test selection technique proposed for object-oriented programs is the Class firewall regression test selection technique. The selection technique selects test cases for regression test, which test changed classes and classes that depend on changed classes. However, in empirical studies of the application of the technique, we observed that another technique found the same defects, se

The gonadotropin-releasing hormone (GnRH) analog buserelin causes enteric neuronal loss. Acute stress or injection of corticotropin-releasing factor (CRF) affects motility, secretion, and barrier function of the gastrointestinal tract. The aim of the study was to characterize the CRF immunoreactivity in enteric neurons after buserelin treatment, and to evaluate possible effects of enteric neuropat