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A Data-Driven Approach Identifies Subtypes of Caries From Dental Charting

Objectives: The objectives were to: (i) assess the accuracy of dental data for adults obtained from the Swedish Quality Register on Caries and Periodontitis (SKaPa); (ii) explore whether Latent Class Analysis (LCA) can identify groups of people based on caries data; and (iii) characterise the dental, medical and behavioural characteristics of people in the LCA-derived classes. Methods: Caries data

Effect of Oral Insulin on Early Combined Glucose and C-Peptide Endpoints in Individuals at High-Risk for Type 1 Diabetes

Background: The TrialNet Oral Insulin (OI) prevention trial showed no overall treatment effect, using the diagnosis of type 1 diabetes as an endpoint. A significant delay in onset was only found in a high-risk stratum (termed secondary stratum 1) of participants with low first-phase insulin release (FPIR).Methods: Since trials with an endpoint of type 1 diabetes take years to complete, in this pos

Microbial carbon utilization in a boreal lake under the combined pressures of brownification and eutrophication : insights from a field experiment

Climate and land use changes can increase terrestrial runoff to aquatic systems, leading to brownification and eutrophication in northern boreal lakes. Brownification may boost bacterial respiration and production, while eutrophication can enhance primary production and algal blooms. However, their combined effects on basal producers and bacterial carbon utilization are less understood. This study

Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects

Apidaecin 1b (Api), the first characterized Type II Proline-rich antimicrobial peptide (PrAMP), is encoded in the honey bee genome. It inhibits bacterial growth by binding in the nascent peptide exit tunnel of the ribosome after the release of the completed protein and trapping the release factors. By genome mining, we have identified 71 PrAMPs encoded in insect genomes as pre-pro-polyproteins. Ha

Learned Trajectory Embedding for Subspace Clustering

Clustering multiple motions from observed point trajectories is a fundamental task in understanding dynamic scenes. Most motion models require multiple tracks to estimate their parameters, hence identifying clusters when multiple motions are observed is a very challenging task. This is even aggravated for high-dimensional motion models. The starting point of our work is that this high-dimensionali

Unveiling the hippocampal subfield changes across the Alzheimer’s disease continuum : a systematic review of neuroimaging studies

Studies exploring the hippocampal subfield atrophy in Alzheimer’s disease (AD) have shown contradictory results. This review aims to disentangle such heterogeneity by investigating the dynamic changes of hippocampal subfields across the AD continuum. We systematically searched the PubMed and EMBASE databases for case-control studies. Selected studies included investigations of biomarker-based amyl

Agency and structure in regional development : in search of a social science research programme

As a concept, agency stretches from philosophical and meta-theoretical elaborations to studies documenting largely idiosyncratic happenings in a particular empirical context, which could be dismissed as anecdotal. In between, and the source for the recent revival of scholarly interest, lies the promise to explain transformation processes, multiplex governance, and varieties in wellbeing and develo

Sherpas and Sagarmatha : complexity theory, ‘Edge of Chaos’ and implications for tourism risk management

Sagarmatha (Everest) has long been recognised as one of the principal goals of global adventure tourism. Supported by high-altitude workers, paying climbers on Sagarmatha have the opportunity to tread in the footsteps of colonial pioneers such as George Mallory and Sir Edmund Hillary. Ever since the first attempt was made to summit Sagarmatha there has been an appreciation amongst the climbing com

Preparation and Utilization of a Highly Discriminative Absorbent Imprinted with Fetal Hemoglobin

Development in hemoglobin-based oxygen carriers (HBOCs) that may be used as alternatives to donated blood requires an extensive supply of highly pure hemoglobin (Hb) preparations. Therefore, it is essential to fabricate inexpensive, stable and highly selective absorbents for Hb purification. Molecular imprinting is an attractive technology for preparing such materials for targeted molecular recogn

Reaction mechanism of pyridine radicals with molecular oxygen : A theoretical study

Pyridine is a suitable surrogate of the fuel-nitrogen in flame studies. The goal of the present work was to extend the analysis of reactions of pyridyl radicals with O2. All reactions proceed following similar mechanisms, through the barrier-free addition of an O2 molecule and further development along two main paths: through barrier-free abstraction of an oxygen atom and through the formation of

Spatial–Temporal Assessment of Eco-Environment Quality with a New Comprehensive Remote Sensing Ecological Index (CRSEI) Based on Quaternion Copula Function

The traditional remote sensing ecological index (RSEI), based on principal component analysis (PCA) to integrate four evaluation indexes: greenness (NDVI), humidity (WET), dryness (NDBSI), and heat (LST), is insufficient to comprehensively consider the influence of each eco-environment evaluation index on eco-environment quality (EEQ). In this research, a new comprehensive remote sensing ecologica

An extreme thermal cycling reliability test of ATLAS ITk Strips barrel modules

At the end of Run 3 of the Large Hadron Collider (LHC), the accelerator complex will be upgraded to the High-Luminosity LHC (HL-LHC) in order to increase the total amount of data provided to its experiments. To cope with the increased rates of data, radiation, and pileup, the ATLAS detector will undergo a substantial upgrade, including a replacement of the Inner Detector with a future Inner Tracke

Evidence for an active ice margin during the last deglaciation : the Vimmerby Moraine, South Swedish Uplands

The Vimmerby Moraine is the only significant ice-marginal moraine on the eastern side of southern Sweden, but no detailed studies exist on its formation during the final deglaciation of the Fennoscandian Ice Sheet. Through ground-penetrating radar surveys and detailed sediment logging, we provide evidence for an active, oscillating ice margin during the formation of the Vimmerby Moraine, suggestin

A Simulator Study on the Driver Failure and Traffic Conflict in Lane Change Situations on a 2+1 Road

This study examined driver failure and traffic conflict using a driving simulator during lane-change scenarios on a 2+1 road, focusing on differences between day and night conditions. Data on driver failure status and driving behavior were captured through a survey. The study also evaluated driver performance and electrodermal activity. The findings revealed that nighttime lane changes had a short

Incidence and prevalence of multiple sclerosis in Malmö, Southern Sweden.

Objectives. To estimate the incidence and prevalence of multiple sclerosis (MS) in Malmö municipality in southwestern Sweden. Materials and Methods. Multiple sources were used in the case identification process. Case ascertainment was assessed by medical chart review including examinations such as magnetic resonance imaging, cerebrospinal fluid analyses, and relevant laboratory tests. Cases were c