The presence of conventional dendritic cells type 1 (cDC1) in the tumor correlates with positive treatment outcome. The ability to cross-present neoantigens and prime protective CD8+ T-cell responses, makes cDC1s central for tumor immunity. However, in tumors cDC1 are rare and often functionally impaired. Our group reported that overexpression of the transcription factors PU.1, IRF8 and BATF3 (PIB

BACKGROUND: Emergency department (ED) crowding causes increased patient morbidity and mortality. ED occupancy rate (OR; patients by treatment beds) is a common measure of crowding, but the comparability of ORs between EDs is unknown. The objective of this investigation was to investigate differences in ORs between EDs using staff-perceived workload as reference.METHODS: This was a national cross-s

OBJECTIVE: To compare experts' perceived usefulness of audit filters from Ghana, Cameroon, WHO and those locally developed; generate context-appropriate audit filters for trauma care in selected hospitals in urban India; and explore characteristics of audit filters that correlate to perceived usefulness.DESIGN: A mixed-methods approach using a multicentre online Delphi technique.SETTING: Two large

The ordinary cities are the dominant sites of urban living, theorization and debates. This presentation centrally situates the dimension of urban density to unfold a unique, however, ordinary aspect of urban contention. It situates the state’s formal housing paradigm for the urban poor as the case of theoretical intervention from an ongoing research project. It aims to broaden the understanding of

As a state where the ruling communist party operates in a central planning mode, the policies of the ruling party and central government exert a great influence on national affairs with a long historical tradition in China, which can be even more obviously illustrated in the issues of climate change. But on the other hand, there is still no specific national climate legislation in China, which is

This debate concerns the relevance and suitability of the ‘Chinese model’ of environmental governance for the rest of the world as other countries grapple with how to govern climate change. Tianbao Qin and Meng Zhang argue that heavily directed and enforced environmental regulation, as manifested in China, is an efficient and effective form of governance for bringing about the necessary structural

Is China a superhero intent on saving the world economy or a monster focused on damaging the global environment? As a developing country with the largest population in the world, China has wrought a stunning miracle of economic development. However, this rapid economic growth, like a double-edged sword, has given rise to severe environmental problems, such as climate change, water pollution and re

Nowadays China is increasingly facing strong international pressures to reduce carbon emissions, standing at the cross-road of climate change issues: how to fulfill the emission reduction goal without undermining and blocking its ambitions on sustainable economic development. Facing this situation, carbon capture and storage（CCS）can be a new weapon for China to win the battle of climate change mit

The Chinese government is acutely aware of the problem of climate change. In the crucial crossroads, carbon emissions trading scheme (ETS), a kind of market-based instruments based on cap-and-trade, has become the new hope of carbon governance and the most important measure adopted to mitigate climate change. Based on the description and analysis on the ongoing process of pilot ETS in China and it

PurposeTo analyse structural characteristics of malformations of cortical development (MCD) at 7T and 3T MRI.MethodsTwenty-five patients were examined with a 7T MRI-scanner in addition to 3T examinations performed for epilepsy evaluation. 7T sequences included a 3D-T1-weighted (T1w) MPRAGE, 3D-T2w FLAIR, and heavily T2w axial and coronal high-resolution (0.5×0.5×0.75-1.0 mm3) 2D-TSE sequences. Ima

Climate change and its associated challenges may have an impact on people and communities. Studies provide conceptual and empirical insight of the relationship between social capital and resilience. However, the social dimensions of resilience have received little attention in climate change research. This short article provides a rapid review of published studies that investigate the social dimen

Urbanization is a major contributor to biodiversity declines. However, studies assessing effects of urban landscapes per se (i.e., disentangled from focal habitat effects) on biodiversity across spatial scales are lacking. Understanding such scale-dependent effects is fundamental to preserve habitats along an urbanization gradient in a way that maximizes overall biodiversity. We investigated the i

Land sharing versus land sparing describes contrasting strategies to conserve biodiversity while maintaining agricultural production. We comprehensively reviewed empirical studies comparing land-sharing and land-sparing strategies to assess how these were conceptualized and how consequences for biodiver- sity, commodity production, and additional ecosystem services have been quantified. Out of 52