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Attosecond dynamics of multi-channel single photon ionization

Photoionization of atoms and molecules is one of the fastest processes in nature. The understanding of the ultrafast temporal dynamics of this process often requires the characterization of the different angular momentum channels over a broad energy range. Using a two-photon interferometry technique based on extreme ultraviolet and infrared ultrashort pulses, we measure the phase and amplitude of

Aerosol formation and emissions from realistic compartment fires

Firefighters are occupationally exposed to a large number of toxic compounds (IARC 2010). The occupational exposure of firefighters has been classified as potentially carcinogenic (class 2B, IARC; (Straif K. et al. 2007)). Poorly quantified emission factors and low understanding of when various aerosol emissions are likely to form during a fire event (initiation, combustion, extinguishing) inhibit

Survival trends of patients with non-metastatic gastric adenocarcinoma in the US and European countries : the impact of decreasing resection rates

BACKGROUND: We previously observed decreasing resection rates of non-metastatic gastric adenocarcinoma (GaC) in the US and some European countries. If and to what extent these trends affect the trends in overall survival (OS) of patients with non-metastatic GaC at the population level remain unclear. This large international population-based cohort study aimed to assess the impact of the previousl

A low-cost and open-source protocol to produce key enzymes for molecular detection assays

Here, we describe a detailed step-by-step protocol for the expression, purification, quantification, and activity determination of key enzymes for molecular detection of pathogens. Based on previous reports, we optimized the protocol for LbCas12a, Taq DNA polymerase, M-MLV reverse transcriptase, and TEV protease to make it compatible with minimal laboratory equipment, broadly available in low- and

Monitoring mental distress in Para athletes in preparation, during and after the Beijing Paralympic Games 2022: A 22 week prospective mixed-method study

It is common in elite sport to monitor athletes' training load, injuries and illnesses, but mental distress is rarely included. An improved understanding of the epidemiology of mental distress among elite Para athletes and how their coaches perceive such monitoring would allow us to better develop and implement preventive measures. The purpose of this study was therefore to (1) prospectively descr

Locked in unsustainability : Understanding lock-ins and their interactions using the case of food packaging

Lock-in mechanisms are major hurdles to sustainability transitions. Scholars identified various types of lock-ins; however, their dynamics and interactions remain underexplored. Using the case of food packaging, this study enhances the conceptual understanding and empirical analysis of lock-ins and their interactions from a socio-technical perspective. We analyze the material, institutional, behav

Design and implementation of tailored intervention to increase vaccine acceptance in a Somali community in Stockholm, Sweden - based on the Tailoring Immunization Programmes approach

Objectives: Sweden has had a high and stable vaccination coverage for measles-mumps-rubella (MMR) vaccine (>96%) through the national immunization program (NIP), but coverage rates highlight local pockets of lower vaccination coverage. This project addressed low MMR vaccine acceptance among parents in a Somali community, in Stockholm. The objective of the intervention was to increase vaccine confi

Pathways to a Sustainable Blue Economy in Latin America and the Caribbean

After a 7-year slowdown in economic growth in the previous decade, LAC opened this decade with the adverse effects of Covid. The economic slowdown and the health crisis jeopardized the SDGs’ implementation in the region. In this chapter, the authors revisit the old question of whether the previous decade of LAC is another lost decade, mainly adding the environmental dimension to the economic and s

strengur

An album released by Carrier Records. It includes performances and compositions and videographic works by Davíð Brynjar Franzson, Luong Hue Trinh, Kent Olofsson, Halla Steinunn Stefánsdóttir and Mirjam Tally. Information by Stefánsdóttir, taken from the album website:strengur is a set of five groups of three pieces, each group created in deep collaboration with a long-term creative partner. For th

Free-stream turbulence and tube spacing effects on surface pressure fluctuations for two tubes in an in-line arrangement

An experimental investigation of surface pressure distributions (mean and r.m.s.) on two tubes (circular cylinders) mounted in an in-line or tandem arrangement was carried out in a low-speed, closed-circuit wind tunnel. The measurements were mainly performed at a subcritical Reynolds number, Re = 2·0 × 104, at three different turbulence intensities of the approaching cross-flow (0·1, 1·4 and 3·2%)

External electric field-dependent photoinduced charge transfer in non-fullerene organic solar cells

Based on Marcus theory, the photoinduced electron transfer properties of D-A type non-fullerene acceptor organic solar cells (OSCs) under the dependence of external electric field (Fext) were investigated. The research results shown that the charge transfer mode under different Fext intensities changes with certain regularity. Focusing on the important parameters (ΔG, λ, and VDA) that affect the c

Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents

Depressive symptoms are associated with altered pupillary responses during learning and reward prediction as well as with changes in neurometabolite levels, including brain concentrations of choline, glutamate and gamma-aminobutyric acid (GABA). However, the full link between depressive symptoms, reward-learning-related pupillary responses and neurometabolites is yet to be established as these con

Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease

We have developed an efficient approach to generate functional induced dopaminergic (DA) neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of patient fibroblasts with idiopathic Parkinson's disease (PD), we could specifically detect disease-relevant pathology in these cells. We show that the patient-derived neurons maintain age-related properties of the donor and

Astrocytic function is associated with both amyloid-β and tau pathology in non-demented APOE 4 carriers

A growing body of evidence suggests that astrocytes play a major role in the pathophysiology of Alzheimer's disease. Given that APOE is primarily expressed in astrocytes, these cells might be an important link between the APOE ϵ4 allele and the development of Alzheimer's disease pathology. Here, we investigate this hypothesis in vivo by measuring myo-inositol, a metabolite involved in astrocytic f

Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers

Background: Alzheimer’s disease (AD) is foremost characterized by β-amyloid (Aβ)-extracellular plaques, tau-intraneuronal fibrillary tangles (NFT), and neuroinflammation, but over the last years it has become evident that peripheral inflammation might also contribute to the disease. AD patients often demonstrate increased levels of circulating proinflammatory mediators and altered antibody levels