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Lipase-catalyzed production of structured triacylglycerols

Vegetable oils and fats are major energy sources but also play an essential part in the physical and chemical properties of food products. The current change in the climate is affecting harvest yields, leading to a shortage and increased prices of raw materials that are difficult to replace. In addition, there is an increasing demand for new products with positive health effects.Triacylglycerols (

Topological Dynamics of Micelles Formed by Geometrically Varied Surfactants

The molecular architecture of sugar-based surfactants strongly affects their self-assembled structure, i.e., the type of micelles they form, which in turn controls both the dynamics and rheological properties of the system. Here, we report the segmental and mesoscopic structure and dynamics of a series of C16 maltosides with differences in the anomeric configuration and degree of tail unsaturation

Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells

Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and is caused by the degeneration and loss of dopamine (DA) neurons in the ventral midbrain (VM). The focal and progressive degeneration of DA neurons in the VM makes PD a particularly attractive target for cell-based therapies. Human pluripotent stem cells (hPSCs) offer unprecedented opportunities to model the

Simulation of unsteady three-dimensional flow around a square cylinder at moderate Reynolds numbers

Direct numerical simulations of two-dimensional (2D) and 3-D unsteady flow around a square cylinder for moderate Reynolds numbers (Re=150–500) are performed, employing an implicit fractional step method finite-volume code with second-order accuracy in space and time. The simulations, which are carried out with a blockage ratio of 5.6%, indicate a transition from 2-D to 3-D shedding flow between Re

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The current debate on the Anthropocene is thus far dominated by the natural sciences. This leads to a simplistic analysis of environmental devastation and the underlying changes of human-nature relations. In this commentary, we urge the discipline of political science to enhance its engagement in the debate on the so-called human age and its far-reaching implications. The Anthropocene is character

On parallel time in population protocols

The parallel time of a population protocol is defined as the average number of required interactions in which an agent in the protocol participates, i.e., the quotient between the total number of interactions required by the protocol and the total number n of agents, or just roughly the number of required rounds, where a round stands for a sequence of n consecutive interactions. This naming trigge

Heat exchanger network optimisation considering different shell-side flow arrangements

Heat exchanger network synthesis (HENS) is an effective tool for heat recovery in chemical and petrochemical industries. This study aims to show a method for HENS with the consideration of different shell-side flow arrangements in shell-and-tube heat exchangers. The proposed MINLP model is modified from the stage-wise superstructure model, incorporating newly developed correlations for shell-side

Rationale and design of the “NEurodegeneration : Traumatic brain injury as Origin of the Neuropathology (NEwTON)” study: a prospective cohort study of individuals at risk for chronic traumatic encephalopathy

Background: Repetitive head injury in contact sports is associated with cognitive, neurobehavioral, and motor impairments and linked to a unique neurodegenerative disorder: chronic traumatic encephalopathy (CTE). As the clinical presentation is variable, risk factors are heterogeneous, and diagnostic biomarkers are not yet established, the diagnostic process of CTE remains a challenge. The general

It's not just a Tree: a Story about Nature-based Solutions

A tree is so much more than just a tree! Trees provide habitat to support biodiversity, remove carbon dioxide and particulate matter from our air, cool our cities during summers, and inspire enjoyment by all. A tree planted deliberately to provide any of these services is considered a nature-based solution. In this episode, we present the concept of nature-based solutions as an approach to reduce

The Stringent Response Inhibits 70S Ribosome Formation in Staphylococcus aureus by Impeding GTPase-Ribosome Interactions

During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in Staphylococcus aureus. These enzymes are cofactors in ribosome assembly, where they cycle between the ON (GTP-bound) and OFF (GDP-bound) ribosome-associated

DNA aptamers for the recognition of HMGB1 from Plasmodium falciparum

Rapid Diagnostic Tests (RDTs) for malaria are restricted to a few biomarkers and antibody-mediated detection. However, the expression of commonly used biomarkers varies geographically and the sensibility of immunodetection can be affected by batch-to-batch differences or limited thermal stability. In this study we aimed to overcome these limitations by identifying a potential biomarker and by deve

Interaction between freestream turbulence and vortex shedding for a single tube in crossflow

The effect of freestream turbulence on the flow past a circular cylinder (tube) was studied experimentally for Reynolds numbers between 2 x 104 and 6 x 104. Investigations were carried out for uniform (non-turbulent) flow and for turbulent flows having turbulence intensities between 1.3 and 4.1%. The variations in the pressure forces and shedding frequencies were found to be related to the variati

Controlling inventories in omni/multi-channel distribution systems with variable customer order-sizes

The fast growth of e-commerce and omni/multi-channel retailing brings new challenges for efficient inventory management. One such challenge concerns service differentiation across channels when upstream central warehouses satisfy both direct customer demand and replenishment orders from downstream retailers. Motivated by industry collaboration, we address this issue by developing a combined stock

Planar laser-induced imaging of CH3 for high resolution single-shot reaction-zone visualization in premixed methane/air flames over broad stoichiometric ratios

We report a novel approach for single-shot planar imaging of CH3 radicals in premixed methane and air flames. A 213 nm beam from the 5th harmonic of an Nd:YAG laser was resonantly absorbed by the CH3 radicals, which were excited to the highly pre-dissociative upper level and dissociated to H2 and CH (X), as the main dissociation channel. The CH radicals were consequently excited by a 388 nm beam f

Lack of autoantibodies against collagen and related proteins in collagenous colitis

INTRODUCTION: Collagenous colitis (CC) is a common cause of chronic diarrhea and is characterized by a subepithelial thickened collagen layer in the colonic mucosa. It shares many of the characteristics found in autoimmune diseases, but no autoantibodies have been identified. In CC, an imbalance in collagen turnover is evident. The purpose of the present study was to investigate whether any collag

Investigating out-of-plane strength & stiffness of a nailed glulam connection

During March 2020 a large-span arena, Tarfalahallen, collapsed. The main load-bearing girders with a 54 m span were high and slender glulam trussed beams, supported from below by a cable system via vertical struts. Investigations concluded that the failure was initiated by out-of-plane buckling of the struts and slender beam, in spite of lateral stabilization by steel roof sheeting at the top edge

Assessing the accuracy of [18F]PSMA-1007 PET/CT for primary staging of lymph node metastases in intermediate- and high-risk prostate cancer patients

Background: [18F]PSMA-1007 is a promising tracer for integrated positron emission tomography and computed tomography (PET/CT). Objective: Our aim was to assess the diagnostic accuracy of [18F]PSMA-1007 PET/CT for primary staging of lymph node metastasis before robotic-assisted laparoscopy (RALP) with extended lymph node dissection (ePLND). Design, Setting and Participants: The study was a retrospe

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Public and private policies typically consider the construction of infrastructure the most appropriate response to the problems of water scarcity and water disputes. However, infrastructure in itself not always is the solution. In this context we have the following questions: What are the logics behind the construction and implementation of water infrastructure? Why water infrastructures are not a

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The phenomena of landgrabbing and monopolizing of water sources have gained increasing attention in recent years. Nevertheless, very few studies have dealt with the problem of the grabbing and concentration of resources from an ethnographic perspective that would make it possible to illustrate the different ways in which dispossession takes place, as well as its concrete mechanisms and effects in