The granulation of a tablet formulation in a high-speed mixer, Diosna P 25
The impeller speed, the loss-on-drying of starch, and the added amount of water significantly influenced these response variables: granule fractions of less than 0.150 mm and more than 2.00 mm; and granule median diameter. The influence of the drug concentration on the response variables was less important. All the response variables showed significant interactions. At a fixed impeller speed, the
