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Coagulation activation and venous thromboembolism (VTE) are hallmarks of cancer; however, there is an unmet need of improved biomarkers for individualized anticoagulant treatment. The present sub-study of the RASTEN trial was designed to explore the role of coagulation biomarkers in predicting VTE risk and outcome in a homogenous cancer patient population. RASTEN is a multicenter, randomized phase

The performance of the missing transverse momentum (ETmiss) reconstruction with the ATLAS detector is evaluated using data collected in proton–proton collisions at the LHC at a centre-of-mass energy of 13 TeV in 2015. To reconstruct ETmiss, fully calibrated electrons, muons, photons, hadronically decaying τ-leptons , and jets reconstructed from calorimeter energy deposits and charged-particle trac

Covalent organic networks derived from surface-mediated self-assembly of 1,3,5-tris(4-bromophenyl)benzene into two-dimensional networks on Au(111) have been studied by scanning tunneling microscopy (STM) and by X-ray spectroscopic methods. High resolution soft X-ray photoemission spectroscopy (SXPS) using synchrotron radiation have been used to study the formation of the 1,3,5-tris(4-bromophenyl)b

It is important to minimize transmission heat transfer losses through the building envelope when designing and building energy efficient buildings in heating dominated climates. In such a climate, a large part of the space heating demand is caused by transmission heat transfer losses through the building envelope. Calculations of these losses must be carried out in a correct way to ensure a proper

A search is performed for resonant and non-resonant Higgs boson pair production in the γ γ bb¯ final state. The data set used corresponds to an integrated luminosity of 36.1 fb−1 of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. No significant excess relative to the Standard Model expectation is observed. The observed

This paper explores the impact of new universities established in the USA between 1931 and 1980 on population density, GDP and market size measured from 1930 to 2010. The analysis is based on differences in differences on counties selected through propensity score matching, as well as an instrumental variable approach. The evidence suggests that counties hosting a university for the first time gre

While colloids have been widely employed as models for atoms and molecules, the current study proposes to extend their use as building blocks for supracolloidal frameworks. Hereby, the self-assembly between highly anisotropic supramolecular microtubules and soft spherical fluorescent microgels is explored using confocal laser scanning microscopy. The influence of the particle size and charge with

The novel wrought nickel-based superalloy, AD 730™, is a good candidate material for turbine disc applications at high temperatures beyond 650 °C. The present study focuses on the machining performance of this newly developed alloy under high-speed turning conditions with advanced PCBN tools. Meanwhile, the machined surface integrity as influenced by cutting speed and feed rate was also investigat

We report the measured transverse momentum (pT) spectra of primary charged particles from pp, p-Pb and Pb-Pb collisions at a center-of-mass energy sNN=5.02 TeV in the kinematic range of 0.15 < pT< 50 GeV/c and |η| < 0.8. A significant improvement of systematic uncertainties motivated the reanalysis of data in pp and Pb-Pb collisions at sNN=2.76 TeV, as well as in p-Pb collisions at sNN=5.02 TeV, w

A high-resolution chemostratigraphical (coupled δ13Ccarb and δ18Ocarb) study of the topmost Floian through the middle Darriwilian (Ordovician) succession at the Hällekis quarry, Kinnekulle, southern Sweden, shows relatively steady isotopic values with overall minor changes, although some notable short- and long-term shifts are discernible. A pronounced positive shift in δ13C in the uppermost part

Preparation of metal-halide perovskites under room temperature attracts attention because of energy saving by removing thermal annealing. Room-temperature transformation of spin-cast wet films consisting of methylammonium (MA) iodide, PbI2, and dimethylformamide toward solid MAPbI3 perovskite proceeds via several intermediate crystalline states and is strongly dependent on ambient humidity. Light

Immunophenotypic characterization and molecular analysis have long been used to delineate heterogeneity and define distinct cell populations. FACS is inherently a single-cell assay, however prior to molecular analysis, the target cells are often prospectively isolated in bulk, thereby losing single-cell resolution. Single-cell gene expression analysis provides a means to understand molecular diffe

Bacteria utilize complement regulators as a means of evading the host immune response. Here, we describe protocols for evaluating the role vitronectin acquisition at the bacterial cell surface plays in resistance to the host immune system. Flow cytometry experiments identified human plasma vitronectin as a ligand for the bacterial receptor outer membrane protein H of Haemophilus influenzae type f.

In the face of reduced public funding of science and increased demands for ‘value for money’, academic researchers find themselves hard pressed to produce relevant research and demonstrate their utility to society. These pressures are particularly prominent in the humanities and social sciences (HSS) where practical value is frequently questioned. This article investigates how HSS can be made ‘rel

From 2012 USA universities entered new partnerships with private sector companies including Silicon Valley start-up Coursera. Coursera spearheads a new broad online learning segment of the fast growing global ‘educational technology’ (EdTech) sector. They offered free ‘massive open online courses’ (MOOCs) for global, universal learner audiences. Since 2015 several USA universities and Coursera exp

Current EU policy calls for decreased emissions of greenhouse gases (GHG) by i.e., replacing fossil fuel in the transportation sector with sustainable biofuels. To avoid indirect land use change (iLUC), the EU at the same time strives to limit the use of crops and to increase the use of residues. In this study we compare climate impact and production cost for biogas and ethanol based on wheat grai

During the last decades, several research groups have used bisphosphonates for local application to counteract secondary bone resorption after bone grafting, to improve implant fixation or to control bone resorption caused by bone morphogenetic proteins (BMps). We focused on zoledronate (a bisphosphonate) due to its greater antiresorptive potential over other bisphosphonates. Recently, it has beco

In recent years, the International Maritime Organization agreed on aiming to reduce shipping's greenhouse gas emissions by 50% with respect to 2009 levels. Meanwhile, cruise ship tourism is growing at a fast pace, making the challenge of achieving this goal even harder. The complexity of the energy system of these ships makes them of particular interest from an energy systems perspective. To illus