Background: Circulating biomarkers can facilitate diagnosis and risk stratification for complex conditions such as heart failure (HF). Newer molecular platforms can accelerate biomarker discovery, but they require significant resources for data and sample acquisition. Objectives: The purpose of this study was to test a pragmatic biomarker discovery strategy integrating automated clinical biobanki

For metallic glasses, it is of vital importance to understand the glass formation properties and to be able to predict the crystallization process in the supercooled liquid. In the present work, we model the process of nucleationand growth using a combination of classical nucleation and phase-field theory. A diffusion coupled phase-field model is used to evaluate the work of formation and the growFor metallic glasses, it is of vital importance to understand the glass formation properties and to be able to predict the crystallization process in the supercooled liquid. In the present work, we model the process of nucleation and growth using a combination of classical nucleation and phase-field theory. A diffusion coupled phase-field model is used to evaluate the work of formation and the gro

The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ42), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau181) have proven diagnostic accuracy for mild cognitive impairment and dementia due to Alzheimer’s Disease (AD). In an effort to improve the accuracy of an AD diagnosis, it is important to be able to distinguish between AD and other types of dementia (n

Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiological gaps that exist within the various AR treatment classes

Purpose: To evaluate the potential for right ventricular reverse remodelling after pulmonary valve replacement using cardiac magnetic resonance imaging, in adults with corrected tetralogy of Fallot and severe pulmonary insufficiency. Material and methods: Ten patients with previous correction of tetralogy of Fallot with severe pulmonary insufficiency accepted for pulmonary valve replacement were

Context: Open tools (e.g., Jenkins, Gerrit and Git) offer a lucrative alternative to commercial tools. Many companies and developers from OSS communities make a collaborative effort to improve the tools. Prior to this study, we developed an empirically based theory for companies’ strategic choices on the development of these tools, based on empirical observations in the telecom domain. Aim: The ai

We report the first examples of the carbide ligand in (Cy 3 P) 2 Cl 2 Ru≡C (RuC) developing into a μ 3 ligand toward metal centers. Conventionally, sterics exclude this coordination mode, but Fe 2 (CO) 9 and Co 2 (CO) 8 expel bridging CO ligands upon reaction with RuC to form trimetallic (Cy 3 P) 2 Cl 2 Ru=CFe 2 (CO) 8 (RuCFe 2 ) and (Cy 3 P) 2 Cl 2 Ru=CCo 2 (CO) 7 (RuCCo 2 )

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess whether continuous glucose monitoring (CGM) versus any intermittent monitoring modalities to measure glycemia improves neurodevelopmental outcomes in preterm newborn infants.

In this research, a methodology was applied to integrate hydraulic simulation model, HEC-RAS and GIS analysis for delineation of flood extents and depths within a selected reach of Zaremroud River in Iran. Floodplain modeling is a recently new and applied method in river engineering discipline and is essential for prediction of flood hazards. It is necessary to simulate complicated hydraulic behav

På uppdrag av länsstyrelserna i Dalarna, Jämtland och Gävleborgs län har Avdelningen för Riskhantering och Samhällssäkerhet vid Lunds Universitet utvärderat hur länsstyrelserna hanterade de omfattande skogsbränderna under sommaren 2018. Syftet med utvärderingen har varit att analysera hur länsstyrelserna tillsammans bidrog till inriktning och samordning av samhällets samlade resurser. Med utgångsp

In this research a method to calibrate a river hydraulic model (HEC-RAS) using ground-based measurements of an observed flash flood is presented. Applications of the ground truth measurement of flood water depths and flooded areas within a reach of Neka River in Northern of Iran are discussed. The model is calibrated using the Manning's roughness coefficient based on 200-year flood event that took

This study presents the results of open-ended contingent valuation method (CVM) to estimate the residents' maximum willingness to pay (WTP) for flood insurance and structural flood control measures in the Neka River Basin in Northern Iran. Flood inundation analysis and floodplain risk mapping were conducted by applying the HEC-RAS model combined with GIS analysis. A calibrated 100-year flood risk