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Mutation-bearing peptide ligands from mutated nucleophosmin-1 (NPM1) protein have been empirically found to be presented by HLA class I in acute myeloid leukemia (AML). We hypothesized that HLA genotype may impact allogeneic hematopoietic stem cell transplantation (allo-HCT) outcomes in NPM1-mutated AML owing to differences in antigen presentation. We evaluated the effect of the variable of predic

The language that individuals use for expressing themselves contains rich psychological information. Recent significant advances in Natural Language Processing (NLP) and Deep Learning (DL), namely transformers, have resulted in large performance gains in tasks related to understanding natural language. However, these state-of-the-art methods have not yet been made easily accessible for psychology

Introduction The coefficient of fat absorption (CFA) quantifies fat that remains in stool after digestion and is not a direct measure of lipolysis. CFA has been used to assess treatment of pancreatic insufficiency but does not correlate with pancreatic enzyme replacement therapy dose. We explored use of an omega-3 substrate absorption challenge test as a sensitive test of lipolysis and absorption.

Purpose: To analyse trends of ISBCS reported to the Swedish National Cataract Register (NCR) over a 10-year period. Methods: Since 2010 the NCR contains social security number of all individuals in the list of parameters reported to NCR after each cataract procedure. Bilateral surgeries were mapped out using social security numbers. When dates of both-eye surgeries are identical for an individual

In soil, arbuscular mycorrhizal fungi (AMF) meet the roots of both host and presumed nonhost plants, but the interactional mechanisms of AMF with and functional relevance for nonhost plants is little known. Here we show AMF can colonize an individually grown nonhost plant, Arabidopsis thaliana, and suppress the growth of Arabidopsis and two nonhost Brassica crops. This inhibitory effect increased

This edited volume discusses the emergence and development, and in some cases also the disappearance, of social movements and activism in the Swedish 1980s. The introductory chapter gives the background and aim of the volume and discusses why the Swedish case is interesting from a European perspective. The 1980s have often been described as a decade when the radical social movements of the 1960s a

Decolonization is a situated effort as it relates to the relations of privilege, power, politics, and access (3P-A, in Albarrán González’s terms) between the people involved in design in relation to wider societies. This complexity creates certain challenges for how we can understand, learn about, and nurture decolonization in design towards pluriversality, since such decolonizing effort is based

Socialdemokraternas tidigare ledare Ingvar Carlsson underskattar sin nyliberala pionjärinsats. ”Har han inte förstått vad han sysslat med som statsråd och statsminister?”, frågar sig professor Lars Jonung.

Binding between ligands and receptors across cell contacts influences a range of biological processes including the formation of the immune synapse. The dissociation constant (Kd = 1/affinity) of the interaction corresponds to the concentration of ligands where half of the receptors in the contact have bound a ligand. In this chapter, we outline how to measure this two-dimensional affinity using m

Background: Adherence to adjuvant tamoxifen therapy is suboptimal, and acceptance of tamoxifen for primary prevention is poor. Published results indicate effect of low-dose tamoxifen therapy. Using questionnaire data from a randomised controlled trial, we describe side effects of standard and low-dose tamoxifen in healthy women. Methods: In the KARISMA trial, 1440 healthy women were randomised to

Forced cross-border migration and entrepreneurship have persisted as perennial themes throughout the annals of human history. However, the recent ‘refugee crisis’ has sparked a resurgence of interest in their interplay under the rubric of ‘refugee entrepreneurship’. While its territory is not entirely uncharted, a surge in scholarly urgency and heightened scientific production have significantly e

Silicon (Si) phases such as biogenic silica, lithogenic silicate and authigenic silica/silicate in marine sediments provide valuable information about past Si cycling. Wet-chemical sequential leaching methods are often applied to extract different Si phases from marine sediments to study Si diagenetic processes in shallow subsurface. The potential of this method to separate Si phases from deeply-b

Adolescent mothers face numerous challenges. This study aimed to address the operationalisation of the new South African national policy for young mothers by testing the associations of potential protective provisions with three policy goals: School return, grade promotion, and pregnancy/HIV prevention. Adolescent mothers aged 12–24 from rural and urban communities of South Africa’s Eastern Cape c

Objectives: To evaluate the total number of false-positive recalls, including radiographic appearances and false-positive biopsies, in the Malmö Breast Tomosynthesis Screening Trial (MBTST). Methods: The prospective, population-based MBTST, with 14,848 participating women, was designed to compare one-view digital breast tomosynthesis (DBT) to two-view digital mammography (DM) in breast cancer scre

This chapter investigates how reports in Swedish mainstream media framed the 1980s peace movement collective actions in Sweden. By revisiting press coverage of protest events, the analysis identifies the central characteristics of the framing. Primarily, the protests are found to be framed in positive terms and successfully conveyed what Charles Tilly and others have noted as key for a social move

The Winter Palace (TWP) was a venue and association within the left-wing alternative environment in Malmö between 1987–1989, with premises in the port area. The venue ran a pub and café; arranged concerts, public lectures, and movie screenings; broadcasted radio; published fanzines; and more. The idea was that the proceeds would be used to build a Southern Swedish center for anarchist propaganda a

We investigated 390 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) patients treated according to NOPHO ALL 2008, regarding copy number alterations (CNA) of eight loci associated with adverse prognosis, including IKZF1. The impact on outcome was investigated for each locus individually, combined as CNA profiles and together with cytogenetic information. The presence of IKZF1 de