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Cardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes : A Mendelian Randomization Study Using Data From the Malmö Diet and Cancer Study and the UK Biobank

Objective: To investigate the causal role of cardiometabolic risk factors in osteoarthritis (OA) using associated genetic variants. Methods: We studied 27,691 adults from the Malmö Diet and Cancer Study (MDCS) and replicated novel findings among 376,435 adults from the UK Biobank. Trait-specific polygenic risk scores for low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol

A model for granite evolution based on non-equilibrium magma separation : evidence from the Gharib and Qattar fluorite-bearing granites, Eastern Desert, Egypt

We present 77 new granite whole-rock analyses from the Qattar and Gharib areas, Eastern Desert, Egypt. Both areas include a “normal” granite and either a hypersolvus (Gharib) or an almost plagioclase-free granite (Qattar) enriched in fluorite. According to earlier results, F influences element distribution in granitic melts forming complexes with specific elements as Nb, Ta, Ga, Hf, Th, Zn, Sn, w

Students' explanation : Wider variety of teaching methods increases motivation and give higher results in biology

According to a previous study, results in one topic within an Upper Secondary School Biology course were increased due to student centered, formative working methods. The current study investigates student's perspective on the reasons for the observed increase in performance through focus group discussions. According to the findings, there was not a single factor explaining the increased result, b

Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

Background/Objectives: Motor impairment induced by traumatic brain injury (TBI) may be mediated through changes in spinal molecular systems regulating neuronal plasticity. We assessed whether a focal controlled cortical impact (CCI) TBI in the rat alters expression of the Tgfb1, c-Fos, Bdnf, and Gap43 neuroplasticity genes in lumbar spinal cord. Approach/Methods: Adult male Sprague-Dawley rats (n

Model-based monitoring of industrial reversed phase chromatography to predict insulin variants

Downstream processing in the manufacturing biopharmaceutical industry is a multistep process separating the desired product from process- and product-related impurities. However, removing product-related impurities, such as product variants, without compromising the product yield or prolonging the process time due to extensive quality control analytics, remains a major challenge. Here, we show how

Warning for excessive positivity : Authentic leadership and other traps in leadership studies

We study authentic leadership as a prominent but problematic example of positive leadership that we use as a more general “warning” against the current fashion of excessive positivity in leadership studies. Without trying to cover “everything”, we critically examine the principal tenets of mainstream authentic leadership theory and reveal a number of fundamental flaws: shaky philosophical and theo

The structure of emergent prefabricated housing industries : a comparative case study of Australia and Sweden

Prefabricated housing is a disruptive innovation struggling to take hold in a traditional complex product system (CoPS). It is quicker to produce and has improved environmental performance compared to traditional housing. CoPS have more dense and complex network connections than commodity industries, making disruptive innovation more difficult. Effective relational capabilities can achieve the coo

Validation of a brief Multicultural Cognitive Examination (MCE) for evaluation of dementia

Background: The aims of this study were to present the psychometric properties of a newly designed cognitive screening instrument, the Multicultural Cognitive Examination (MCE), and to compare it with the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural population. Methods: The study was a Western European cross-sectional multicenter study. The MCE consists of four components

Stopover departure decisions in autumn are not associated with constitutive immune function in Northern Wheatears Oenanthe oenanthe

Stopover periods in between migratory flights determine the speed of migration and as such may affect birds’ fitness. The decision to leave a stopover site is affected by, for example, energy stores and weather conditions. We investigated whether immunological state influences autumn stopover departure decisions in Northern Wheatear (Oenanthe oenanthe), a nocturnal long-distance migrant. We measur

Association between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients with Alzheimer Disease

Importance: Plasma neurofilament light (NfL) has been suggested as a noninvasive biomarker to monitor neurodegeneration in Alzheimer disease (AD), but studies are lacking. Objective: To examine whether longitudinal plasma NfL levels are associated with other hallmarks of AD. Design, Setting, and Participants: This North American cohort study used data from 1583 individuals in the multicenter Alzhe

Can we reduce the workload of mammographic screening by automatic identification of normal exams with artificial intelligence? A feasibility study

Purpose: To study the feasibility of automatically identifying normal digital mammography (DM) exams with artificial intelligence (AI) to reduce the breast cancer screening reading workload. Methods and materials: A total of 2652 DM exams (653 cancer) and interpretations by 101 radiologists were gathered from nine previously performed multi-reader multi-case receiver operating characteristic (MRMC

Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-b aggregates

The aggregates of the Ab peptide associated with Alzheimer's disease are able to both grow in size aswell as generate, through secondary nucleation, new small oligomeric species, that are major cytotoxins associated with neuronal death. Despite the importance of these amyloid fibril-dependent processes, their structural and molecular underpinnings have remained challenging to elucidate. Here, we c

A novel missense variant in IDH3A causes autosomal recessive retinitis pigmentosa

Background: Inherited retinal degenerations (IRDs) encompass a wide spectrum of genetic ocular diseases characterized by considerable genetic and clinical heterogeneity. Methods: Complete ophthalmic examination and next-generation sequencing. Results: We describe a patient with no family history of vision loss, who at the age of 28 years developed visual impairment consistent with a severe form of

Species of Horismenus Walker (Hymenoptera : Eulophidae) associated with bruchid beetles (Coleoptera: Chrysomelidae: Bruchinae), including five new species

Species of Horismenus Walker associated with bruchid beetles are investigated and five new species are described. Some of the new species are very similar to already described species and have previously been misidentified. The new species include H. depressoides sp. nov. similar to H. depressus Gahan, H. stator sp. nov. similar to H. missouriensis (Ashmead), and H. dennoi & H. multistriatus s