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Dual peptide insertion in capsid of Adeno-associated virus

Modifierade virus ökar effektivitet i behandling av genetiska sjukdomar Det finns virus som är helt ofarliga för oss människor som forskare har insett att man kan utnyttja till vår fördel. Detta genom att placera en fungerande version av en trasig gen, som har orsakat en sjukdom, i ett ofarligt virus och injicera det i patienten. Viruset kan sedan transportera genen till cellerna och sjukdomen boAdeno-associated virus (AAV) is in gene therapy, a widely studied viral vector for delivering therapeutic genes to cure genetic diseases. A major limitation of the wild type AAV is its broad tissue tropism, which necessitates high viral doses to achieve therapeutic efficacy in target tissue. Despite its non-pathogenic profile, high doses can cause adverse immune responses. In this study, the capsi

Ethics of Transparency in Gamified System Exploring Transparency and Ethical Implications in Gamification

As gamification becomes increasingly integrated into digital systems, concerns around its ethical implications have gained relevance. This thesis investigates transparency as a central ethical issue in the socio-technical usage of gamified systems. While prior research has focused on user engagement and system design, less attention has been paid to how transparency is understood and enacted by th

Min mamma har Alzheimers, vad gör jag nu? En studie om stöd till unga anhöriga med en demenssjuk förälder

There is a lack of research on how young adults experienced having a parent with a dementia-related illness, particularly regarding the support they received. This knowledge gap risked leaving young relatives without adequate help, as existing support systems were often designed for older relatives. Therefore, it was essential to explore their needs and experiences. The aim of this study was to ex

Challenges and Opportunities of Big Data Analytics in Swedish SMEs: A Qualitative Study Investigating Employee Perceptions

This study investigates how employees in Swedish small and medium-sized enterprises (SMEs) perceive the challenges and opportunities of adopting Big Data Analytics (BDA). The study adopts a qualitative approach, conducting semi-structured interviews with employees from SMEs across different industries. Guided by the Unified Theory of Acceptance and Use of Technology (UTAUT), the research investiga

Why did the Deepwater Horizon oil spill not transform the Mexican Gulf’s oil extraction frontier?

This thesis examines how political and corporate actors discursively framed the risks associated with deepwater drilling, following the Deepwater Horizon oil spill 2010. Despite the scale and severity of the disaster, the deepwater oil production in the Mexican Gulf has increased since 2010. Through a Critical Discourse Analysis, using Corpus Linguistics tools, the US Government and BP’s public pr

Characterizing microplastics in biofertilizer. Insights into particle properties and environmental impact

Karakterisering av mikroplaster i biogödsel - insikter i partikelegenskaper och miljöpåverkan Mikroplaster i biogödsel kan bidra till att sprida giftiga föroreningar i miljön. När all vår plast bryts ner till mikro-plaster och hamnar i naturen kan den sprida toxiska ämnen och problem långt bortom den ursprungliga källan. Bio-gödsel från våra hushållssopor kan upplevas som en grön lösning – men deThe significant increase in global plastic production has led to its widespread environmental accu-mulation. Soil has become a major sink for microplastics, originating from sources like biofertilizers. This study aims to link the characteristics of microplastics in biofertilizer with their possible envi-ronmental effects, specifically focusing on the sorption of contaminants. Microscopy was emplo

Bedömning av muntlig narrativ förmåga hos skolbarn: ett instrument och fyra mikrostrukturella mått

Introduktion: Bedömning av narrativ förmåga ger viktig information om funktionell kommunikation. Ett bedömningsinstrument som kan lämpa sig för äldre barn och kan ge underlag för analys av narrativ mikrostruktur är Expression, Reception and Recall of Narrative Instrument (ERRNI). Studiens syfte var att utforska ERRNI och fyra mikrostrukturella mått i en svensk kontext. Metod: En deskriptiv och korIntroduction: Assessing narratives provides key insights into functional communication. An instrument which is appropriate for older children and can facilitate an analysis of narrative microstructure is Expression, Reception and Recall of Narrative Instrument (ERRNI). The purpose was to explore ERRNI and four microstructural measures in a Swedish context. Method: A descriptive correlational desi

Towards a Circular Economy in Rural Mozambique: Managing End-of-Life Solar Home Systems

The background for this thesis is that access to sustainable electricity is part of the United Nations’ Sustainable Development Goals for 2030. In Sub- Saharan Africa, approximately 570 million people lacked access to electricity in 2022. To expand access in rural areas, solar home systems and other off-grid solar products offer affordable and accessible solutions. However, as these systems reach

Collective Intuitivism

The legacy of colonialism still wields a powerful grip: „through the property it occupies, the capital it is financed by, the materials it is constructed from, the underpaid migrant labour that continues to construct it, and the expertise that benefits from it through accumulations of social and financial capital“ (Herscher, 2021). Sadly, nothing of this incomplete list is within the past; we are

CYBERSECURITY CHALLENGES TO AIRLINES A LITERATURE REVIEW OF RISK & COMPLIANCE

This thesis reviews existing research on how cybersecurity affects flight safety and to what extent these threats are addressed in regulatory requirements. This mixed method thesis employs anchoring in safety science, systematic literature review, legal requirements analysis, interviews, and a survey. Research shows risks related to unencrypted VHF/HF radio, CPDLC, ACARS, Mode-S, ADS-B, TCAS and G

UX Investigation of Future Service Tool for Technicians

I det morderna samhället spelar appar en central roll. Detta gäller även på Assa Abloy Entrance Systems, där appar används av tekniker för att installera, underhålla och reparera automatiska dörrar. Just nu utvecklas en app som kommer att ersätta alla nuvarande appar. Bakgrunden till detta examensarbete var att involvera framtida användare i utvecklingsprocessen med målet att förbättra användbApps are a central part of modern society, including technicians at Assa Abloy Entrance systems. They use several apps for installing, maintaining and repairing automatic doors. A new app is currently in development to replace all existing apps. The background of this master’s thesis project was to involve future users in the development process with the aim to enhance usability and work satisfac

Buried but Not Gone – Internal Phosphorus Loading in Lake Vomb

På botten i en av Skånes största dricksvattensjöar gömmer sig gamla synder från förr. På sommaren kommer de till ytan och orsakar problem med vattnets kvalité och gör sjön ovälkomnande grön. I denna studie går vi till botten av problemet med förhöjda näringshalter i Vombsjön. Sedan en lång tid tillbaka har orenat avloppsvatten och vatten från jordbruksmark runnit in i Vombsjön. Vattnet har innIn this study, the internal load of phosphorus in Lake Vomb is explored. Years of external inputs from untreated sewage and agricultural runoff have built up tonnes of phosphorus in the lake sediment, periodically released causing HABs and impairing water quality. The aim of this study is to investigate how the internal load varies over a year and to explore correlations between internal loading,

"Det är så lätt att sållas bort" - röster från livet på gatan

This study aimed to explore how individuals with experience of homelessness perceived the available support services, as well as how they experienced their encounters with social workers, highlighting effective current practices and identifying areas needing improvement. Based on narrative interviews with six formerly homeless individuals in Stockholm, Sweden, their experiences were analysed using

Cirkulära stålkonstruktioner - Design för Demontering & Återbruk

Bygg- och fastighetssektorn står för en avsevärd del av Sveriges klimatpåverkan och resursanvändning, där stålproduktionen är en betydande faktor. Trots att stål är ett material med hög återvinningsgrad är direktåterbruket av bärande stålkomponenter i dagsläget begränsat. Detta utgör en outnyttjad potential för att minska koldioxidutsläpp och främja en cirkulär ekonomi, där Design för Demontering The construction and real estate sector accounts for a considerable share of Sweden's climate impact and resource use, with steel production being a significant factor. Although steel is a material with a high recycling rate, the direct reuse of load-bearing steel components is currently limited. This represents an untapped potential for reducing carbon dioxide emissions and promoting a circul

Synthesis of a Linear Symmetrically Fused Tröger's Base Analogue

Julius Tröger first synthesised ‘C17H18N2’ as an unknown product from the condensation of anilines with formaldehyde. From that point on, the history of Tröger’s base (TB) has widely evolved as new applications for its characteristic rigid, chiral framework easy to functionalise. It is in the field of supramolecular chemistry that TB has gathered the most attention these last years. This work is f

Religion and union outcomes: Relationship between religion and premarital cohabitation and marriage in Northern Ireland, 1998-2023.

This thesis investigates the relationship between Protestant and Catholic religious affiliation and union outcomes, as well as religiosity and union outcomes in Northern Ireland. I conduct a multinomial logistic regression analysis using pooled cross-sectional data from the Northern Ireland Life and Times survey from 1998–2023. I find that cohabitation has increased in the 21st century, and that r

Deceptive patterns eller smart UX-design?

Denna kandidatuppsats undersöker hur användare uppfattar så kallade ”deceptive patterns” - vilseledande designmönster - i digitala användargränssnitt, samt var gränsen går mellan påverkan och manipulation. Studien kombinerar en kvantitativ enkätundersökning med en kvalitativ intervjustudie för att fånga både bredd och djup i ämnet. Enkäten, som riktades till svenska internetanvändare, inkluderade

Breathing New Life into a Food Street: Improvement Design for Reffen Food Street

History leaves its marks on the life of a city. As urban landscapes continue to expand and evolve, old industrial sites and urban functions are often left behind, fading into the margins of the contemporary city. This thesis seeks to explore how architecture and public space can breathe new life into these forgotten areas, reactivating them as meaningful parts of the city’s present and future.The