Conventional technical system is designed with all details in the product development phase. Conditions of operation and modes of behaviour are known and validated before the product is launched to the market. This deterministic way of thinking is built into regulations procedures and it is requested at validation when safety is an issue. The existing way of validation that is based on predictive

Knowledge management (KM) in the engineering change management process is crucial for any manufacturing enterprise. Increasing complexity triggers an increasing demand for systematic management of information and knowledge. KM is of strategic importance to a successful management of an enterprise, especially when the key staff changes. Systematically gathered, analyzed and interpreted professional

The main advantages of polymer gears in comparison to metal gears are low manufacturing costs for mass production, vibration damping and no need for lubricant. In the literature and guidelines, the allowable gear endurance limits for bending and contact stresses are mainly given for polyamides (PA) and polyacetals (POM). The large number of suitable polymer gear materials is available, but the sta

Objective: Cigarette smoking and alcohol drinking are preventable risk factors in surgery. It is unknown whether intervening on these two risk factors also have an effect on other lifestyles. Therefore, the primary aim of this study was to compare the effect of an intensive alcohol and smoking cessation intervention on other lifestyles (malnutrition, obesity, and physical inactivity) with treatmen

Background: Experimental analyses of the 3D strain field evolution during loading allows for better understanding of deformation and failure mechanisms at the meso- and microscale in different materials. In order to understand the auxetic behaviour and delamination process in paperboard materials during tensile deformation, it is essential to study the out-of-plane component of the strain tensor t

Only some individuals with obesity develop liver fibrosis due to non-alcoholic fatty liver disease (NAFLD-fibrosis). We determined whether detailed assessment of lifestyle factors in addition to physical, biochemical and genetic factors helps in identification of these patients. A total of 100 patients with obesity (mean BMI 40.0 ± 0.6 kg/m2 ) referred for bariatric surgery at the Helsinki Univers

Minnesord över en förgrundsfigur inom den svenska sexarbetarrörelsen. Andersson var en av medgrundarna till Sexualpolitisk Front, Nordens första sexarbetarorganisation. Under hela sitt vuxna liv arbetade hon för att sexsäljares situation i samhället skulle förbättras, och 2017 tilldelades hon Jasminepriset, föreningen Rose Alliances pris för arbete mot våld mot sexarbetare,

Background: There is yet no clear consensus on which method is preferable in secondary breast reconstructions, prosthesis, or autologous tissue. Methods: In this first prospective randomized study, 29 women underwent reconstruction with expander prosthesis (EP) and 44 with deep inferior epigastric perforator (DIEP) flap. Inclusion started in 2012 and ended in 2018. Demographic data, complications,

CONTEXT: The I148M (rs738409-G) variant in PNPLA3 increases liver fat content but may be protective against cardiovascular disease. Insulin resistance (IR) amplifies the effect of PNPLA3-I148M on liver fat. OBJECTIVE: To study whether PNPLA3-I148M confers an antihyperlipidemic effect in insulin-resistant patients. DESIGN: Cross-sectional study comparing the impact of PNPLA3-I148M on plasma lipids

This article presents a lifespan testing analysis of polymer gears manufactured by cutting. Compared to injection molding, machine cutting provides higher accuracy of gear geometry. Two different tooth flank geometries were tested; i.e. involute and S-gears. In theory, S-gears have several advantages over involute gears due to the convex/concave contact between the matching flanks. The theoretical

Background: As many countries seek to slow the spread of COVID-19 without reimposing national restrictions, it has become important to track the disease at a local level to identify areas in need of targeted intervention. Methods: In this prospective, observational study, we did modelling using longitudinal, self-reported data from users of the COVID Symptom Study app in England between March 24,

The use of digital tools in education is subject to debate in school as well as in wider society. This motivates studies on the potential of these tools to facilitate teaching and learning. One of the digital tools being used is Google Classroom (GC). In order to increase knowledge of its usage and effects in content teaching, semi-structured interviews were conducted with 18 teachers in Swedish cThe use of digital tools in education is subject to debate in school as well as in wider society. This motivates studies on the potential of these tools to facilitate teaching and learning. One of the digital tools being used is Google Classroom (GC). In order to increase knowledge of its usage and effects in content teaching, semi-structured interviews were conducted with 18 teachers in Swedish c

Glyoxalase I (GlxI) is an important enzyme that catalyzes the detoxification of methylglyoxal (MG) with the help of glutathione (H-SG). It is currently unclear whether MG and H-SG are substrates of GlxI or whether the enzyme processes hemithioacetal (HTA), which is nonenzymatically formed from MG and H-SG. Most previous studies have concentrated on the latter mechanism. Here, we study the two-subs

Composite cryogels containing boronic acid ligands are synthesized for effective separation and isolation of bacteria. The large and interconnected pores in cryogels enable fast binding and release of microbial cells. To control bacterial binding, an alkyne-tagged boronic acid ligand is conjugated to azide-functionalized cryogel via the Cu(I)-catalyzed azide−alkyne cycloaddition reaction. The boro

Introduction: Infantile hypertrophic pyloric stenosis (IHPS) is caused by hypertrophy of the pyloric sphincter muscle. Objectives: Since previous reports have implicated lipid metabolism, we aimed to (1) investigate associations between IHPS and a wide array of lipid-related metabolites in newborns, and (2) address whether detected differences in metabolite levels were likely to be driven by genet

Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent the main reason for treatment discontinuation. Mitochondrial dysfunction of complex I has been implicated in the pathophysiology of SAMS. The present study proposed to assess the concentration-dependent ex vivo effects of three statins on mito-chondrial respi