Background: For BRCA1 and BRCA2 mutation carriers, the association between oral contraceptive preparation (OCP) use and breast cancer (BC) risk is still unclear.Methods: Breast camcer risk associations were estimated from OCP data on 6030 BRCA1 and 3809 BRCA2 mutation carriers using age-dependent Cox regression, stratified by study and birth cohort. Prospective, left-truncated retrospective and fu

Background: Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestat

Objective: The TLR3/cGAS-STING-IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved. Our study aimed to investigate the influence of potential regulatory variants in these genes on the risk of sporadic colorectal cancer (CRC) in a Czech cohort of 1424 CRC patients and 1114 healthy controls. Methods: The variants in the TL

AIMS/HYPOTHESIS: Substantial deposition of the extracellular matrix component hyaluronan (HA) is characteristic of insulitis in overt type 1 diabetes. We investigated whether HA accumulation is detectable in islets early in disease pathogenesis and how this affects the development of insulitis and beta cell mass.METHODS: Pancreas tissue from 15 non-diabetic organ donors who were positive for islet

While previous research has demonstrated that gaze position can increase the accessibility of previous memories when reconstructing the past (Johansson & Johansson, 2014), the present study tested whether such gaze behavior can assist in selecting target memories in the face of competing memories. An adapted retrieval practice paradigm was used, where participants were engaged in selective ret

Partnervåld är ett vida spritt folkhälsoproblem. Ämnets känsliga natur gör detsvårt att analysera, eftersom det är avgörande att kunna skilja en förändringi våld från en förändring i rapportering av våld. Med ett objektivt mått påvåld och oberoende variation i egenmakt skattar jag effekten av ökad kvinnligegenmakt på våld i nära relationer. Jag visar att den deskriptiva relationenmellan egenmakt o

Since the beginning of the Great Recession of 2008, we are witnessing a deepening of social and ecological crises. As a transdisciplinary research program, with a powerful critique of capitalist economy at its core, there is little surprise that we witness an ever-increasing body of literature of Marxist contributions to the fields of (among others) urban and sustainability studies following the c

Tropical Rainfall Measurement Mission (TRMM) is one of the most popular global high resolution satellite-based precipitation products with a goal of measuring precipitation over the oceans and tropics. However, in recent years, the TRMM mission has come to an end. Its successor, Global Precipitation Measurement (GPM) mission was launched to measure the earth's precipitation structure, with an aim

Extreme climate events such as severe droughts and floods have become more frequent and widespread in the 21st Century. Recent studies have revealed the tele-connections between Madden–Julian Oscillation (MJO) and extreme precipitation over different regions such as South America, India and China. This study investigates the influence of MJO on global extreme dry and wet conditions, and how the st

Lake Tana is the largest lake in Ethiopia, and its lake outflowis the source of the BlueNile River that provides vital water resources for many livelihoods and downstream/international stakeholders. Therefore, it is essential to quantify and monitor the water balance of Lake Tana. However, Lake Tana is poorly gauged, with more than 50% of Lake Tana Basin being ungauged from in-situ measurements, m

Growing scientific evidence for the indispensable role of environmental sustainability in sustainable development calls for appropriate frameworks and indicators for environmental sustainability assessment (ESA). In this paper, we operationalize and update the footprint-boundary ESA framework, with a particular focus on its methodological and application extensions to the national level. By using

This study conducted a comprehensive evaluation of three satellite precipitation products (TRMM (Tropical Rainfall Measuring Mission) 3B42, CMORPH (the Climate Prediction Center (CPC) Morphing algorithm), and PERSIANN (Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks)) using data from 52 rain gauge stations over the Meichuan watershed, which is a represent

The commonly used Soil Conservation Service Curve Number (SCS-CN) for surface runoff modeling is largely dependent on the Hydrologic Soil Groups (HSGs) which are derived through aggregation of all soil types into four hydrologic groups. The derived CN largely mutes away original soil attribute details. A fuzzy approach refining CN according to soil hydrologic properties was developed to preserve d