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Aims: Huntington disease (HD) is a fatal neurodegenerative disorder with no disease-modifying treatments approved so far. Ongoing clinical trials are attempting to reduce huntingtin (HTT) expression in the central nervous system (CNS) using different strategies. Yet, the distribution and timing of HTT-lowering therapies required for a beneficial clinical effect is less clear. Here, we investigated
Proportionality reasoning is an established form of legal argumentation under international human rights law, employed by the European Court of Human Rights and the United Nations (UN) human rights treaty bodies alike. However, relatively little has been written about its precise role and content in relation to equality norms. Proportionality scholars tend to draw on other examples to demonstrate
Stereotypa föreställningar och negativ behandling av äldre finns dokumenterade sedan antik tid. Numera används begreppet ålderism, vilket avser fördomar och diskriminering mot äldre. Ibland har begreppet också definierats som något som handlar om ålder över hela livsloppet. Den här antologin består av 15 kapitel där forskare belyser ålderismens varierade uttrycksformer och komplexitet. I antologin
SKA Construction phase we are now in a transition phase that hopefully will prepare us for the next challenge: start building the SKA. One of the targets of this period is to evaluate the suitability of the Taranta (proper Webjive) Suite for creating engineering User Interfaces (UIs). The Taranta suite is a framework that allows the fast creation of web UIs that directly communicate with TANGO dev
Lately have the demands on good room acoustics in public ordinary rooms increased. Traditionally has only reverberation time been considered in this type of rooms but complementary parameters as sound strength and speech clarity are more commonly used today. This trend naturally implies higher demands on the acoustic treatment. Typical for public ordinary rooms is to use an absorbent ceiling. One
This article presents a study aiming to explore and evaluate acoustic comfort in residential multistory buildings in Sweden. Acoustic data was associated to self-reported responses acquired by a survey: a questionnaire was setup researching the response to noise annoyance from multiple sources in a flat and the emotional reactions of tenants to the acoustic climate at home. An assessment of acoust
In cancer tumor detection, tissue autofluorescence and characteristic features of injected hematoporphyrin derivative (HPD) can be utilized. The authors have studied the importance of the excitation wavelength for the achievable contrast between tumor and surrounding tissue using a rat tumor model. They have also compared the relative merits of two HPD preparations for tumor fluorescence detection
What are the long-term differences in the propensity of immigrants to acquire destination country citizenship under different institutional contexts and how do these vary between migrant groups? This article draws on micro-level longitudinal data from administrative registers in Denmark, the Netherlands, and Sweden—three countries with widely different and changing requirements for the acquisition
Alternative ways for increased appetite control are today widely sought for due to the growing global health issues connected to obesity. In in vivo studies, oat has been proven an attractive candidate for inducing satiety. Oat is rich in polar lipids, of which the galactolipids are especially interesting, and a hypothesis is that these lipids play an important role for the ileal brake mechanism.
Plastics play an essential role in modern society, but also lead to significant impacts on the environment and climate. Reducing such impacts while retaining the usefulness of plastics requires a shift towards a more circular and sustainable plastics system. This report tells the story of plastics, and their effect on the environment and climate, and looks at their place in a European circular eco
Studies of laser-induced fluorescence in rat tissues, including cancer tumors have been performed. Contrast enhancement techniques have been developed which improve the ability to localize a tumor when using fluorescence from the tumor-seeking substance hematoporphyrin derivative (HPD). A multi-color fluorescence imaging technique has been tested. A discussion of clinical applications is included.
Non-smooth convex optimization problems occur in all fields of engineering. A common approach to solving this class of problems is proximal algorithms, or splitting methods. These first-order optimization algorithms are often simple, well suited to solve large-scale problems and have a low computational cost per iteration. Essentially, they encode the solution to an optimization problem as a fixe
