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New constraints on the evolution of 87Sr/86Sr of seawater during the Upper Triassic

The Late Triassic time interval witnessed several important biological turnovers, extinctions and onset of new life forms. Therefore, it is crucial to better constrain the tectonic, climatic and oceanographic framework at this time. The radiogenic strontium isotopic composition (87Sr/86Sr) of seawater, recorded in marine carbonates is sensitive to variations in continental weathering and oceanic s

LES/PDF modeling of swirl-stabilized non-premixed methane/air flames with local extinction and re-ignition

Turbulent non-premixed flames with local extinction and re-ignition exhibit multiple combustion modes including ignition waves, diffusion flames, partially premixed flames, and ignition-assisted partially premixed flames. The mechanisms of local extinction and re-ignition are not well understood and numerical modeling of multi-mode combustion is a challenging task. In this work, a specially design

Prevalence and incidence of atopic dermatitis-a systematic review

The primary objective of this study was to systematically review and analyse epidemiological studies of the prevalence and incidence of atopic dermatitis (AD) during childhood and adulthood, focusing on data from the 21st century. A systematic search of PubMed, EMBASE and Google (manual search) was performed in June 2019, followed by data abstraction and study quality assessment (Newcastle–Ottawa

Masters writing the rules: how peasant farmer MPs in the Swedish Estate Diet understood servants’ labour and the labour laws, 1823–1863

Peasant farmers made up one of the four estates in the Swedish parliament, the Diet of the four estates, from late medieval times up until the introduction of the two-chamber parliament in 1867. Affiliation to the estate of the peasant farmers was based on landholding. Landholding also entitled peasant farmers to employ servants. Peasant farmers thus played a double role: as masters of servants an

How can airborne transmission of COVID-19 indoors be minimised?

During the rapid rise in COVID-19 illnesses and deaths globally, and notwithstanding recommended precautions, questions are voiced about routes of transmission for this pandemic disease. Inhaling small airborne droplets is probable as a third route of infection, in addition to more widely recognized transmission via larger respiratory droplets and direct contact with infected people or contaminate

Brister i en studie av domstolarnas bevisvärdering avseende mål om olaga hot och våldtäkt

I SvJT 2018 s. 327 presenterades en studie enligt vilken bevisning som är tillräcklig för en fällande dom i våldtäktsmål inte är tillräcklig för en fäll­ande dom i mål om olaga hot. Det finns dock flera problem med studien som sammantagna innebär att det inte finns stöd för påståendet att bevisning som uppfyller beviskravet i våldtäktsmål inte är tillräcklig i mål om olaga hot. Ett första problem

“Short” or “long” Rhaetian ? Astronomical calibration of Austrian key sections

The establishment of the Late Triassic time scale has given rise to considerable controversy, particularly regarding the Rhaetian duration and the inferred absolute age models. In this respect the astronomical polarity time scale (APTS) established from the continental successions of the Newark Basin (eastern North America) is considered as a reference record, although its completeness is question

The economic value of VIX ETPs

The fairly new VIX ETPs have been promoted for providing effective and easily accessible diversification, while at the same time having large negative returns. We examine the economic value of using VIX ETPs for diversification of stock–bond portfolios. Our analysis begins in 2009, when the first VIX ETPs are introduced, and therefore only considers the period after the recent financial crisis. Fo

A socio-psychological conceptualisation of overtourism

Tourist pressure on local populations, also termed ‘overtourism’, has received much attention in the global media, as tensions related to social, economic or environmental change have grown in many destinations. While protests against tourists and tourism development have existed for decades, these are now often more organised, vocal, and politically active. As a phenomenon associated with residen

Human postprandial responses to food and potential for precision nutrition

Metabolic responses to food influence risk of cardiometabolic disease, but large-scale high-resolution studies are lacking. We recruited n = 1,002 twins and unrelated healthy adults in the United Kingdom to the PREDICT 1 study and assessed postprandial metabolic responses in a clinical setting and at home. We observed large inter-individual variability (as measured by the population coefficient of

Risk concentration under second order regular variation

Measures of risk concentration and their asymptotic behavior for portfolios with heavy-tailed risk factors is of interest in risk management. Second order regular variation is a structural assumption often imposed on such risk factors to study their convergence rates. In this paper, we provide the asymptotic rate of convergence of the measure of risk concentration for a portfolio of heavy-tailed r

Precision medicine in diabetes : a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The convergence of advances in medical science, human biology, data science and technology has enabled the generation of new insights into the phenotype known as ‘diabetes’. Increased knowledge of this condition has emerged from populations around the world, illuminating the differences in how diabetes presents, its variable prevalence and how best practice in treatment varies between populations.

Germline whole genome sequencing in pediatric oncology in Denmark—Practitioner perspectives

Background: With the implementation of a research project providing whole genome sequencing (WGS) to all pediatric cancer patients in Denmark (2016–2019), we sought to investigate healthcare professionals' views on WGS as it was actively being implemented in pediatric oncology. Methods: Semistructured interviews were carried out with pediatric oncologists, clinical geneticists, and research coordi

Are aggressive pituitary tumors and carcinomas two sides of the same coin? Pathologists reply to clinician’s questions

Pituitary adenohypophyseal tumors are considered as benign and termed “adenomas”. However, many tumors are invasive and a proportion of these exhibit an “aggressive behavior” with premature death due to progressive growth. Only very rare (0.2%) tumors with metastases are considered malignant and termed “carcinomas”. Taking into account this variability in behavior and the oncological definition, p

Self-efficacy, recovery and psychological wellbeing one to five years after heart transplantation : a Swedish cross-sectional study

Background: Self-efficacy refers to a person´s confidence in carrying out treatment-related activities and constitutes the foundation of self-management as well as long-term follow-up after heart transplantation. Exploring the heart recipients´ experiences by means of self-report instruments provides healthcare professionals with valuable information on how to supply self-management support after

Evaluating macrophage migration inhibitory factor 1 expression as a prognostic biomarker in colon cancer

Objective: Several studies indicate that macrophage migration inhibitory factor 1 plays a role for tumor progression in colon cancer. We investigated whether determination of migration inhibitory factor 1 mRNA expression levels in lymph nodes of colon cancer patients could be used as a prognostic marker. Methods: Expression levels of migration inhibitory factor 1 and carcinoembryonic antigen mRNAs