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EFFECT OF ELASTIC MISMATCH ON THE GROWTH OF A CRACK INITIALLY TERMINATED AT AN INTERFACE IN ELASTIC PLASTIC BIMATERIALS

A crack perpendicular to, and initially with the tip on, a bimaterial interface is studied. An asymptotic analysis is performed and crack growth proceeds straight ahead at constant remote load. Mode I conditions and plane strain are assumed. The materials on both sides of the interface are elastic perfectly‐plastic with different elastic properties and the same yield stress. A finite element analy

Legitimacy Struggles in Global Governance : Legitimation and Delegitimation of the Asian Infrastructure Investment Bank

The Chinese-led Asian Infrastructure Investment Bank (AIIB) started operation in January 2016 in the context of severe criticism from the U.S. government and transnational civil society organizations, but with the support from major Asian and European states. The establishment of this new global governance institution (GGI) raises intriguing questions concerning legitimacy and (de)legitimation. Wh

Metabolic control of BRISC–SHMT2 assembly regulates immune signalling

Serine hydroxymethyltransferase 2 (SHMT2) regulates one-carbon transfer reactions that are essential for amino acid and nucleotide metabolism, and uses pyridoxal-5′-phosphate (PLP) as a cofactor. Apo SHMT2 exists as a dimer with unknown functions, whereas PLP binding stabilizes the active tetrameric state. SHMT2 also promotes inflammatory cytokine signalling by interacting with the deubiquitylatin

The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase

Human plasma glutathione peroxidase (GSH-Px) is a distinct extracellular selenoenzyme that detoxifies hydroperoxides when used with GSH in high (mM) non-physiological concentrations. We have discovered that NADPH and human thioredoxin reductase (TR) by itself or with thioredoxin (Trx) are efficient electron donors to this human plasma peroxidase. Incubation of 0.05 microM TR with 0.25 microM GSH-P

Sex differences in helping effort reveal the effect of future reproduction on cooperative behaviour in birds

The evolution of helping behaviour in species that breed cooperatively in family groups is typically attributed to kin selection alone. However, in many species, helpers go on to inherit breeding positions in their natal groups, but the extent to which this contributes to selection for helping is unclear as the future reproductive success of helpers is often unknown. To quantify the role of future

Automated Bone Scan Index as an Imaging Biomarker to Predict Overall Survival in the Zometa European Study/SPCG11

BACKGROUND: Owing to the large variation in treatment response among patients with high-risk prostate cancer, it would be of value to use objective tools to monitor the status of bone metastases during clinical trials. Automated Bone Scan Index (aBSI) based on artificial intelligence has been proposed as an imaging biomarker for the quantification of skeletal metastases from bone scintigraphy.OBJE