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Biomarker detection on Pancreatic cancer dataset using entropy based spectral clustering

Pancreatic ductal adenocarcinoma (PDAC) is one of most aggressive malignancy. The identification of Biomarker for PDAC is an ongoing challenge. The high dimensional PDAC gene expression dataset in Gene Expression Omnibus(GEO) database, is analyzed in this work. To select those genes which are relevant as well as with least redundancy among them, we use successive approaches like Filter methods and

Complications, long-term outcome and quality of life following Surgisis® and muscle-covered implants in immediate breast reconstruction : a case-control study with a 6-year follow-up

Background: Matrices are now commonly used in breast reconstruction, but the scientific evidence is still scares. The main aim was to compare complications and the need for corrections in immediate breast reconstruction with the porcine-derived Surgisis® with the traditional muscle-covered technique. The secondary aim was to compare long-term quality of life and satisfaction. Methods: All consecut

Energy efficiency regulations, market and behavioural failures and standardization

Introduction: A large number of policy instruments have been developed to induce energy efficiency and mitigate climate change. Traditional policy evaluations have assessed the performance of individual policy instruments, applying criteria such as target effectiveness, cost-effectiveness, legitimacy and distributional effects. More recently there has been a shift of interest in how policy instrum

Hypermethylation of endoplasmic reticulum disulfide oxidase 1α leads to trophoblast cell apoptosis through endoplasmic reticulum stress in preeclampsia

Abnormal trophoblast cell apoptosis is implicated in the pathogenesis of pregnancy-related disorders including preeclampsia (PE), and endoplasmic reticulum (ER) stress has been considered as a novel pathway in the regulation of cell apoptosis. In this study, we observed that both apoptosis and ER stress are triggered in trophoblast cells under hypoxia as well as in the placenta of PE rats. Quantit

A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus

Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). Methods: PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VO

MCPLOTS : A particle physics resource based on volunteer computing

The mcplots.cern.ch web site (mcplots) provides a simple online repository of plots made with high-energy-physics event generators, comparing them to a wide variety of experimental data. The repository is based on the hepdata online database of experimental results and on the rivet Monte Carlo analysis tool. The repository is continually updated and relies on computing power donated by volunteers,

Evolution effects in Z0 fragmentation into charmonium

In Z0 decay into prompt charmonium, i.e. charmonium not originating from B-meson decays, the most important contribution is expected to come from colour-octet mechanisms. However, previous fixed-order calculations of the colour-octet contribution contain large logarithms which, in a more complete treatment, should be resummed to all orders. We study this resummation by using a Monte Carlo QCD casc

Quark Jet Fragmentation

A semiclassical model is presented for the way the energy of a fast quark is transformed into observable hadrons. It reproduces the features of 1 + 1 dimensional QED (the Schwinger model) concerning a flat rapidity distribution in the central region. In particular the model predicts that the probability to find a meson containing a leading quark is independent of the Feynman scaling variable. Also

Drop size distribution and LWC in Po valley fog

In this paper results are presented of ground-based fog microphysical measurements obtained during the CHEMDROP experiment in the Po Valley (Northern Italy) in November 1994. Altogether about 85 hours of drop microphysical data are analyzed. At the beginning of the experiment a comparison of some of the different microphysical instruments, operated during the experiment, was performed. It has reve