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Molecular and imaging biomarkers of local inflammation at 2 years after anterior cruciate ligament injury do not associate with patient reported outcomes at 5 years

Objective: To estimate the association between molecular or imaging inflammatory biomarkers at 2 years after anterior cruciate ligament (ACL) injury and patient-reported outcomes at 5 years. Methods: For 116 ACL-injured patients, molecular biomarkers of inflammation (synovial fluid and serum cytokines) and Hoffa- and effusion-synovitis as visualized on magnetic resonance imaging (MRI) were assesse

Introduction of a method to calculate cumulative age- And gender-specific lifetime attributable risk (LAR) of cancer in populations after a large-scale nuclear power plant accident

The effect of age and gender in risk estimates related to long-term residence in areas contaminated by nuclear power plant fallout was evaluated by applying the lifetime attributable risk (LAR) concept to an existing exposure model that was previously used for cumulative effective dose estimates. In this study, we investigated the influence of age distribution on the number of cancer cases by appl

The brain of a nocturnal migratory insect, the Australian Bogong moth

Every year, millions of Australian Bogong moths (Agrotis infusa) complete an astonishing journey: In Spring, they migrate over 1,000 km from their breeding grounds to the alpine regions of the Snowy Mountains, where they endure the hot summer in the cool climate of alpine caves. In autumn, the moths return to their breeding grounds, where they mate, lay eggs and die. These moths can use visual cue

Adipose tissue concentrations of dioxins and dibenzofurans in potentially exposed patients with malignant lymphoma or sarcoma

Epidemiological studies have suggested an association between exposure to phenoxyacetic acids, chlorophenols or their contaminating dioxins (PCDDs) and dibenzofurans (PCDFs) and soft-tissue sarcoma and malignant lymphoma. In this study adipose tissue concentrations of PCDDs and PCDFs were measured in nine patients with sarcoma or malignant lymphoma who had been exposed to phenoxyacetic acids or ch

EVAR of AAA: Long term outcomes, disease progression and risk stratification

BackgroundEndovasvular aortic repair (EVAR) is the most commonly utilised technique for the treatment of abdominal aorticaneurysms (AAA) in tertiary referral centers. Detailed long-term outcomes of this technique are relatively scarce,especially for patients presenting symptomatically with AAA. Intra-operatively, proximal type Ia endoleak, involvingblood circulating into the AAA – due to poor prox

Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukaemia patients stopping tyrosine kinase inhibitor therapy

Several studies have now shown that chronic myeloid leukaemia (CML) patients in deep molecular remission may discontinue tyrosine kinase inhibitor (TKI) treatment with a treatment free remission (TFR) rate of approximately 40–60 %. Some factors influencing the possibility of TFR have been described but better tools are needed for individual prediction of long-term TFR. Herein, two multiplex panels

Institutionalizing climate change mitigation and adaptation through city advisory committees: Lessons learned and policy futures

Municipal advisory committees are becoming increasingly influential in guiding decision-making processes that address climatic issues. According to the Adaptigation Institutionalization Framework (included in the recent IPCC report), the implementation of such participatory structures is vital for the effective, joint institutionalization of climate change mitigation and adaptation. However, there

Därför kan nonsens vara värdefullt : Kunskapsresistens i grupper kan bottna i viljan att passa in

Varför låter vi så ofta våra uppfattningar om verkligheten påverkas så mycket av andra personer, även när deras uppfattningar är felaktiga?För att svara på den frågan måste vi nalkas en än mer grundläggande evolutionär fråga – varför människan som art var så framgångsrik under de 99,5 procent av vår historia när släktet Homo levde som nomadiska jägare-samlare. Det är jägare-samlares livsstil som v

Light, Comfort and Joy : User experience of light and darkness in Swedish homes

Avhandlingen undersöker användares upplevelser och beteende kopplat till belysning, ljusarmaturer och fönsteröppningar i svenska hem såväl dag som natt. En kombinerad undersökningsstrategi används där både kvantitativt och kvalitativt material samlats in i fält och i en fullskalemodell av en lägenhet. I avhandlingen identifieras flera motiv bakom boendes ljusrelaterade beteende och val samt faktorThe thesis examines user experience and behaviour relating to lighting, luminaires and window openings during day and night, in Swedish homes. Applying a mixed methods strategy of inquiry, both quantitative and qualitative data were collected in the field and in a full-scale model of an apartment. The thesis has identified multiple motivations behind residents’ lighting behaviour and choices, enab

Innovation and Employment: Process versus Product Innovation

Which kinds of growth lead to increased employment and which do not? This is one of the questions that this important volume attempts to answer. The book explores the complex relationships between innovation, growth and employment that are vital for both research into, and policy for, the creation of jobs.Politicians claiming that more rapid growth would remedy unemployment do not usually specify