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Background: In hereditary angioedema (HAE), low levels (type 1) or defect in function (type 2) of the serine-protease inhibitor C1 Inhibitor protein results in activation of the classical pathway of the complement system as well as the contact system. Here, we investigated the risk of comorbidities in HAE. Methods: Individuals with HAE (n = 239; identified through a physician made diagnosis) and a

Objective: Previous research has suggested an association between physical activity (PA), joint function, and molecular biomarkers, but more studies are needed. The aim of this study was to explore the associations between PA or self-reported joint function and molecular biomarkers of cartilage and inflammation in individuals with hip and/or knee osteoarthritis (OA). Specific objectives were to ex

The bioactivity, biological fate and cytotoxicity of nanomaterials when they come into contact with living organisms are determined by their interaction with biomacromolecules and biological barriers. In this context, the role of symmetry/shape anisotropy of both the nanomaterials and biological interfaces in their mutual interaction, is a relatively unaddressed issue. Here, we study the interacti

In the Ordovician limestone of the Thorsberg quarry (South Sweden), about 130 meteorites have been found. Among the extraterrestrial material, several terrestrial Cr-spinels and zircons have been found too. In particular, in the interval 416–447 cm above the Arkeologen bed, terrestrial Cr-spinels, compositionally different from previous studied Cr-spinels of the same sequence, are present. Previou

Biological nitrogen fixation (BNF) from grain legumes is of significant importance in global agricultural ecosystems. Crops with BNF capability are expected to support the need to increase food production while reducing nitrogen (N) fertilizer input for agricultural sustainability, but quantification of N fixing rates and BNF crop yields remains inadequate on a global scale. Here we incorporate tw

We have implemented and evaluated a secondary organic aerosol scheme within the chemistry transport model TM5-MP in this work. In earlier versions of TM5-MP the secondary organic aerosol (SOA) was emitted as Aitken-sized particle mass emulating the condensation. In the current scheme we simulate the formation of secondary organic aerosol from oxidation of isoprene and monoterpenes by ozone and hyd

This paper demonstrates a method to transform and link textual information scraped from companies' websites to the scientific body of knowledge. The method illustrates the benefit of Natural Language Processing (NLP) in creating links between established economic classification systems with novel and agile constructs that new data sources enable. Therefore, we experimented on the European classifi

This book focuses on the political participation and grassroots mobilization of immigrants and racialized communities in the European context. Based on extensive data collected in Italy, it explores the role that alliances among pro-immigrant groups play in shaping political participation, asking why and how immigrant activists mobilize in hostile environments, why and how they create alliances wi

The Inter-American Court of Human Rights (IACrtHR) has developed in recent years an innovative jurisprudence that has integrated the entity and extension of States’ obligations regarding children’s rights—as established in Article 19 ACHR—through the evolutive, dynamic, and effective interpretation of the American Convention on Human Rights (ACHR). In fact, by acknowledging the existence of an int

The present paper shows that the CCE approach of Pesaran (2006) is more useful than commonly appreciated, in that it enables consistent and asymptotically normal estimation of interactive effects models with heterogeneous slope coefficients when the number of time periods, T, is fixed and only the number of cross-sectional units, N, is large.

Dealing with structural breaks is an essential step in most empirical economic research. This is particularly true in panel data comprised of many cross-sectional units, which are all affected by major events. The COVID-19 pandemic has affected most sectors of the global economy; however, its impact on stock markets is still unclear. Most markets seem to have recovered while the pandemic is ongoin

The United Nations is the arena for a renewed push to regulate transnational corporations (TNCs) and their supply chains. This article analyses the ongoing efforts of a multilateral organization to strengthen the human rights legal framework, especially the design choices posed by the treaty negotiations as well as the role of the UN Human Rights Council in the broader regulatory ecosystem around