Sökresultat

Filtyp

Din sökning på "*" gav 534695 sökträffar

Experimental implementation of precisely tailored light-matter interaction via inverse engineering

Accurate and efficient quantum control in the presence of constraints and decoherence is a requirement and a challenge in quantum information processing. Shortcuts to adiabaticity, originally proposed to speed up the slow adiabatic process, have nowadays become versatile toolboxes for preparing states or controlling the quantum dynamics. Unique shortcut designs are required for each quantum system

Egypt: The State, Foreign Aid and Community Participation in Urban Development Projects

The interplay between international policies and the interests and internal pressures of the state is examined in the context of project‐based community participation in urban shelter provision in Egypt. Three contrasting upgrading projects are used. Using the concept of interest mediation, the paper argues that, whilst the state may be receptive to external pressure for community participation, t

The effect of live attenuated influenza vaccine on pneumococcal colonisation densities among children aged 24–59 months in The Gambia: a phase 4, open label, randomised, controlled trial

Background Influenza and other respiratory viruses promote Streptococcus pneumoniae proliferation in the upper respiratory tract. We sought to investigate for what we believe is the first time, the effect of intranasal live attenuated influenza vaccine (LAIV) on nasopharyngeal S pneumoniae density in a low-income to middle-income country population with high pneumococcal carriage rates. Methods I

Jan Troell

Biographic entry on Swedish film director Jan Troell, b. 1931

Perceived Causal Problem Networks: Reliability, Central Problems and Clinical Utility for Depression

Personalized case conceptualization is often regarded as a prerequisite for treatment success in psychotherapy for patients with comorbidity. This article presents Perceived Causal Networks, a novel method in which patients rate perceived causal relations among behavioral and emotional problems. First, 231 respondents screening positive for depression completed an online Perceived Causal Networks

Effect of nucleation on icy pebble growth in protoplanetary discs

Solid particles in protoplanetary discs can grow by direct vapour deposition outside of ice lines. The presence of microscopic silicate particles may nevertheless hinder growth into large pebbles, since the available vapour is deposited predominantly on the small grains that dominate the total surface area. Experiments on heterogeneous ice nucleation, performed to understand ice clouds in the Mart

Fusidic acid targets elongation factor G in several stages of translocation on the bacterial ribosome

The antibiotic fusidic acid (FA) targets elongation factor G (EF-G) and inhibits ribosomal peptide elongation and ribosome recycling, but deeper mechanistic aspects of FA action have remained unknown. Using quench flow and stopped flow experiments in a biochemical system for protein synthesis and taking advantage of separate time scales for inhibited (10 s) and uninhibited (100 ms) elongation cycl

GTPases IF2 and EF-G bind GDP and the SRL RNA in a mutually exclusive manner

Translational GTPases (trGTPases) are involved in all four stages of protein biosynthesis: initiation, elongation, termination and ribosome recycling. The trGTPases Initiation Factor 2 (IF2) and Elongation Factor G (EF-G) respectively orchestrate initiation complex formation and translocation of the peptidyl-tRNA:mRNA complex through the bacterial ribosome. The ribosome regulates the GTPase cycle

Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

During the stringent response, Escherichia coli enzyme RelA produces the ppGpp alarmone, which in turn regulates transcription, translation and replication. We show that ppGpp dramatically increases the turnover rate of its own ribosome-dependent synthesis by RelA, resulting in direct positive regulation of an enzyme by its product. Positive allosteric regulation therefore constitutes a new mechan

Cofactor dependent conformational switching of GTPases

This theoretical work covers structural and biochemical aspects of nucleotide binding and GDP/GTP exchange of GTP hydrolases belonging to the family of small GTPases. Current models of GDP/GTP exchange regulation are often based on two specific assumptions. The first is that the conformation of a GTPase is switched by the exchange of the bound nucleotide from GDP to GTP or vice versa. The second i

Reading Romans, Constructing Paul(s) : A Conversation between Messianic Jews in Jerusalem and Paul within Judaism Scholars

“Something is going on in Pauline studies,” Paula Fredriksen said of the recent emergence of the “Paul within Judaism” (PWJ) perspective. Almost in parallel, Messianic Judaism has entered the religious scene. One a scholarly and the other a religious community, they both make the same claim: Paul was—and remained—a Jewish believer in Jesus. Hence, both communities propose reading the New Testament

Surgical site infections and antimicrobial resistance after cesarean section delivery in rural Rwanda

Background: As the volume of surgical cases in low-and middle-income countries (LMICs) increases, surgical-site infections (SSIs) are becoming more prevalent with anecdotal evidence of antimicrobial resistance (AMR), despite a paucity of data on resistance patterns. Objectives: As a primary objective, this prospective study aimed to describe the epidemiology of SSIs and the associated AMR among wo

Disordered eating in a community sample of Swedish adolescent girls

Tidigare forskning har visat att störda ätbeteenden (disordered eating/DE) är vanligt bland ungdomar, särskilt bland tonårsflickor. DE definieras som olika beteenden (t.ex. kräkningar, restriktivt ätande) och negativa attityder till ätande/kroppsform/utseende/vikt. Avhandlingen hade flera syften. (1) Att validera en svensk version av frågeformuläret RiBED-8 (risk behaviour for eating disorders) soPrevious research has described that disordered eating (DE) is common in adolescents, especially in girls. DE is defined as maladaptive behaviours (e.g., vomiting) and negative attitudes toward eating and one’s body shape, appearance, and weight. The present thesis had several aims. First, to validate a Swedish version of a Danish 8-item screening inventory, Risk Behaviour for Eating Disorders/RiB

Streaming instability of multiple particle species : II. Numerical convergence with increasing particle number

The streaming instability provides an efficient way of overcoming the growth barriers in the initial stages of the planet formation process. Considering the realistic case of a particle size distribution, the dynamics of the system is altered compared to the outcome of single size models. In order to understand the outcome of the multispecies streaming instability in detail, we perform a large par

Small Alarmone Synthetases as novel bacterial RNA-binding proteins

The alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively referred to as (p)ppGpp, are key regulators of bacterial growth, stress adaptation, antibiotic tolerance and pathogenicity. We have recently shown that the Small Alarmone Synthetase (SAS) RelQ from the Gram-positive pathogen Enterococcus faecalis has an RNA-binding activity (Beljantseva et al. 2017)