Risk-informed decision-making is a key concept in regulatory regimes covering a wide range of technical disciplines and risk domains. Increased standardization in terms of highly prescriptive and detailed requirements is observed in various risk management regulations and application areas. This development has spurred a discussion with equally strong voices promoting and opposing standardization

ObjectivesProstate volume (PV) in combination with prostate specific antigen (PSA) yields PSA density which is an increasingly important biomarker. Calculating PV from MRI is a time-consuming, radiologist-dependent task. The aim of this study was to assess whether a deep learning algorithm can replace PI-RADS 2.1 based ellipsoid formula (EF) for calculating PV.MethodsEight different measures of PV

Background and AimsMRCP is used for diagnosis and follow-up of patients with primary sclerosing cholangitis (PSC). Interest in the prognostic value of MRCP is increasing. The aim of our study is to develop an MRCP-score based on cholangiographic findings previously associated with outcomes and assess its reproducibility and prognostic value in PSC.MethodsThe score (DiStrict-score) was developed ba

A number of guidelines exist with recommendations for diagnosis and management of mitral stenosis (MS). We systematically reviewed existing guidelines for diagnosis and management of MS, highlighting their similarities and differences, in order to guide clinical decision-making. We searched national and international guidelines in MEDLINE and EMBASE (5/4/2011-5/9/2021), the Guidelines Internationa

Background: Alzheimer's disease is characterized by the accumulation of amyloid-β (Aβ) into plaques, aggregation of tau into neurofibrillary tangles, and neurodegenerative processes including atrophy. However, there is a poorly understood spatial discordance between initial Aβ deposition and local neurodegeneration. Objective: Here, we test the hypothesis that the cingulum bundle links Aβ depositi

Purpose To explore associations between perceived loneliness, social isolation, and health complaints among older people. Methods 5804 participants from the Swedish population study “Good Aging in Skåne” were included. Structured interviews and questionnaires were used to assess perceived loneliness, social isolation, 30 somatic and mental-health related symptoms, socio-demographics, lifestyle, an

This study describes the structure of DNA polymerase I from Thermus phage G20c, termed PolI_G20c. This is the first structure of a DNA polymerase originating from a group of related thermophilic bacteriophages infecting Thermus thermophilus, including phages G20c, TSP4, P74-26, P23-45 and phiFA and the novel phage Tth15-6. Sequence and structural analysis of PolI_G20c revealed a 3'-5' exonuclease

This research presents blogs as an innovative and rich tool for political communication. Blogs can facilitate two-way communication and true interaction between citizens and politicians. The article analyses in depth the content,uses, and characteristics of five weblogs written by Aragonese politicians. Although the study detects some weaknesses in the current political use of blogs, it encourages

Objective To compare and summarize the literature regarding infodemics and health misinformation, and to identify challenges and opportunities for addressing the issues of infodemics. Methods We searched MEDLINE®, Embase®, Cochrane Library of Systematic Reviews, Scopus and Epistemonikos on 6 May 2022 for systematic reviews analysing infodemics, misinformation, disinformation and fake news related

OBJECTIVE: To clarify, using an extended adoption design, the sources of parent-offspring transmission for anxiety disorder (AD) and its major subforms and their familial cross-generational relationship with major depression (MD). METHODS: Offspring (born 1960-1992) and their parents, from six family types (intact, not-lived-with biological father or mother, lived-with step-father or step-mother,

[utdrag ur rapportens sammanfattning] Denna rapport behandlar djurbenen från grophusen i Löddeköpinge 90:1, vilka grävdes under 1990. Materialet består av 4638 fragment (ca 31 kg) från 28 grophus. Majoriteten kommer från vikingatida grophus. Analysen kan klassas som ett "återbesök" då materialet tidigare studerats av Johansson (2000). Analysen här aktualiseras av att Löddeköpinge kommer ingå i ett

This photo essay addresses the work and rituals surrounding the making and printing of genealogies in post-socialist China. The essay documents how lineages and printmakers negotiate a new socio-economic environment under the process of heritagization, the materiality and labor of printmaking, and the spaces in which work and rituals takes place. It adds to our understanding of the continuing impo

This dissertation advances a relational theory of rising powers and their influence on international order. The emergence of new great powers and the relative decline of incumbent ones is an inherent feature of world politics. In the modern world, these power transitions have taken place against the background of a core- periphery shaped structure of global relations. Great powers vied for dominan

Background and purposeDiagnostic information about cell density variations and microscopic tissue anisotropy can be gained from tensor-valued diffusion magnetic resonance imaging (MRI). These properties of tissue microstructure have the potential to become novel imaging biomarkers for radiotherapy response. However, tensor-valued diffusion encoding is more demanding than conventional encoding, and

Polypharmacy increases the risk of drug-drug interactions that may disturb treatment effects. The aim of this study was to investigate the frequency of codispensing of potentially interacting or contraindicated drugs related to PH-specific treatment in the Swedish pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) population. All prescribed drugs, on an

Ambulance nurses in prehospital emergency care must assess, treat, and triage patients with mental health issues. This study aimed to investigate the self-perceived competence of ambulance nurses in prehospital emergency care of patients with mental illness. A cross-sectional questionnaire survey was done, a question-index value (Q-IV; range: 0-1.0) was defined as a summary of the proportion of po

PurposeMagnetization transfer saturation (MTsat) is a useful marker to probe tissue macromolecular content and myelination in the brain. The increased B1+ inhomogeneity at 7T and significantly larger saturation pulse flip angles which are often used for postmortem studies exceed the limits where previous B1+correction methods are applicable. Here, we develop a calibration-based correction model an