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Levosimendan: A new dual-action drug in the treatment of acute heart failure

Levosimendan is a new agent for the treatment of acute heart failure. Levosimendan acts via complementary mechanisms; it enhances contractility by sensitising cardiac myofilaments to calcium and dilates blood vessels by opening ATP-dependent potassium channels. In contrast to traditional inotropes (beta-agonists or phosphodiesterase inhibitors), levosimendan does not raise myocyte calcium levels a

Cyclin D3 protein content in human renal cell carcinoma in relation to cyclin D1 and clinico-pathological parameters

Aberrations in the G1/S checkpoint are common in malignancies and are probably important for tumor development. Few G1/S studies have been performed on renal cell carcinoma (RCC) and therefore in this study the cyclin D3 protein content in 80 RCCs and that in 12 corresponding normal kidney cortex tissues are characterized using Western blotting. High cyclin D3 protein content was observed in 16% o

Säsongslagring i bergrum : utvärdering av värmeförluster Lyckebo Uppsala

Utvärderingen av Lyckebo solvärmeanläggnng med säsongslagring i öppet bergrum avslutades den 1 juli 1986. De värmeförluster som då konstaterades föranledde den uppföljning som denna rapport redovisar. Man försöker klarlägga orsakerna till avvikelser mellan beräknade och uppmätta värmeförluster och dra slutsatser för framtida projekt.

DNA ploidy analysis in breast carcinoma. Comparison of unfixed and fixed tissue analyzed by image and flow cytometry

OBJECTIVE: To form a methodologic basis for DNA analysis of ductal carcinoma in situ (DCIS) and invasive carcinoma (IC) of the breast, including very small lesions, by comparison of flow cytometric (FCM) and image cytometric (ICM) methods for DNA quantitation. STUDY DESIGN: The material consisted of 41 DCIS lesions and 26 ICs. FCM DNA analysis of unfixed, frozen samples were compared to (1) FCM of

Individual and contextual determinants of self-reported poor psychological health: A population-based multilevel analysis in southern Sweden.

Objective: To investigate the influence of contextual and individual factors on self-reported psychological health. Design/setting/participants/measurements: The 2000 public health survey in Scania is a cross-sectional postal questionnaire study with a 59% participation rate. A total of 13,715 persons aged 18-80 answered the questionnaire. A multilevel logistic regression model, with individuals a

Nodule detection in digital chest radiography: Introduction to the radius chest trial

Most digital radiographic systems of today have wide latitude and are hence able to provide images with a small constraint on dose level. This opens up for an unprejudiced dose optimisation. However, in order to succeed in the optimisation task, good knowledge of the imaging and detection processes is needed. As a part of the European-wide research project 'unification of physical and clinical req

Fuktsäkerhet i byggnader : generell metod för fuktdimensionering av byggnader

Två tillämpningsexempel visar att den beskrivna fuktdimensioneringsmetoden är praktiskt genomförbar både när det gäller övergripande anvisningar (s k generella checklistor) för olika byggnadsdelar och för exakt definierade kontrollpunkter för en enskild byggnadsdelar (s k projekteringschecklista som redovisar ett oventilerat varmtak med papp eller dukar av gummi eller plast). De anvisningar som fi

Pain and quality of life among older people with rheumatoid arthritis and/or osteoarthritis: a literature review.

The aim of this study was to review the research literature on pain and quality of life (QoL) and the relationship between these variables among people aged 75 years and above with rheumatoid arthritis and/or osteoarthritis. A Medline and CINAHL search was carried out using MeSH terms rheumatoid arthritis, osteoarthritis, QoL and pain in various combinations. Seventeen articles were identified tha

Rigidity of the Doubly-Magic 100Sn Core

The doubly magic nucleus 100Sn represents a crucial test for the nuclear shell model, which is a widely used model for a quantitative description of nuclei. Excited states in 100Sn are experimentally not accessible with present day techniques, but it is possible to gain insight into its structure by studying the properties of excited states of neighboring nuclei. These nuclei are by themselves ver

Modelling the fate of ultrafine particles from exhaust pipe to rural background: an analysis of time scales for dilution, coagulation and deposition

We investigate the time scales of various dynamic processes during the evolution of the particle size distribution from its emission from a vehicle exhaust pipe through its dilution at kerbside and urban level. In addition, the situation in a road tunnel or near a highway is discussed. The derived formula framework allows the estimation of approximated time scales based on a given particle size di

Activities of daily living decrease similarly in hospital-treated patients with a hip fracture or a vertebral fracture: a one-year prospective study in 151 patients

Aims: A hip fracture is commonly regarded as the most devastating fragility fracture, as regards both morbidity and mortality, while a vertebral fracture is usually regarded as having lower general morbidity. The purpose of this study was to investigate whether hospitalized patients with a hip or a vertebral fracture experience similar functional deterioration following the fracture as regards act