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Intestinal fatty acid binding protein as a marker of necrosis and severity in acute pancreatitis

Objectives The aim of this study was to study intestinal fatty acid binding protein (i-FABP) as a potential biomarker in predicting severity of acute pancreatitis (AP). Methods In a prospective multicenter cohort study, plasma levels of i-FABP were measured in 402 patients with AP. Severity of AP was determined based on the 1992 Atlanta Classification. Results Admission levels of plasma i-FABP wer

Effects of JAK1/2 inhibition on bone marrow stromal cells of myeloproliferative neoplasm (MPN) patients and healthy individuals

Objective: Philadelphia-negative myeloproliferative neoplasms (MPNs) commonly share hyperactive JAK-STAT signaling affecting hematopoietic stem cells (HSC) and their progeny. The JAK1/2 inhibitor Ruxolitinib has remarkable clinical efficacy, including spleen reduction, improvement of constitutional symptoms, and bone marrow (BM) fibrosis reversal. Whether this is due to inhibition of JAK2-mutated

Pendulum rides, rotations and the Coriolis effect

An amusement park is full of examples that can be made into challenging problems for students, combining mathematical modelling with video analysis, as well as measurements in the rides. Traditional amusement ride related textbook problems include free-fall, circular motion, pendula and energy conservation in roller coasters, where the moving bodies are typically considered point-like. However, an

Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by increased peripheral immune platelet destruction and megakaryocyte defects in the bone marrow. Although ITP was originally thought to be primarily due to antibody-mediated autoimmunity, it is now clear that T cells also play a significant role in the disease. However, the exact interplay between platelet destruction,

Frost and leaf-size gradients in forests : global patterns and experimental evidence

Explanations of leaf size variation commonly focus on water availability, yet leaf size also varies with latitude and elevation in environments where water is not strongly limiting. We provide the first conclusive test of a prediction of leaf energy balance theory that may explain this pattern: large leaves are more vulnerable to night-time chilling, because their thick boundary layers impede conv

Magnetic hysteresis in self-assembled monolayers of Dy-fullerene single molecule magnets on gold

Fullerene single molecule magnets (SMMs) DySc2N@C80 and Dy2ScN@C80 are functionalized via a 1,3-dipolar cycloaddition with surface-anchoring thioether groups. The SMM properties of Dy-fullerenes are substantially affected by the cycloaddition. Submonolayers of the physisorbed derivatives exhibit magnetic hysteresis on an Au(111) surface at 2 K as revealed by X-ray magnetic circular dichroism.

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations

The aggregation of the amyloid-β (Aβ) peptide is linked to the pathogenesis of Alzheimer’s disease (AD). In particular, some point mutations within Aβ are associated with early-onset familial Alzheimer’s disease. Here we set out to explore how the physical properties of the altered side chains, including their sizes and charges, affect the molecular mechanisms of aggregation. We focus on Aβ42 with

Combination of inclusive and differential (Formula Presented) charge asymmetry measurements using ATLAS and CMS data at (Formula Presented)= 7 and 8 TeV

This paper presents combinations of inclusive and differential measurements of the charge asymmetry (AC) in top quark pair (tt) events with a lepton+jets signature by the ATLAS and CMS Collaborations, using data from LHC proton-proton collisions at centreof- mass energies of 7 and 8TeV. The data correspond to integrated luminosities of about 5 and 20 fb–1for each experiment, respectively. The resu

Comparison between software volumetric breast density estimates in breast tomosynthesis and digital mammography images in a large public screening cohort

Objectives: To compare software estimates of volumetric breast density (VBD) based on breast tomosynthesis (BT) projections to those based on digital mammography (DM) images in a large screening cohort, the Malmö Breast Tomosynthesis Screening Trial (MBTST). Methods: DM and BT images of 9909 women (enrolled 2010–2015) were retrospectively analysed with prototype software to estimate VBD. Software

How to prevent the next fracture

During the last decade, policymakers, learned societies, non-governmental organisations (NGOs) and some national alliances of all three of these groups have advocated, developed and implemented systematic approaches to fragility fracture care and prevention in a growing number of countries. This chapter reviews the impact of Orthogeriatric Services (OGS) and Fracture Liaison Services (FLS) on deli

Matrix-masking to balance nonuniform illumination in microscopy

With a perfectly uniform illumination, the amount and concentration of fluorophores in any (biological) sample can be read directly from fluorescence micrographs. However, non-uniform illumination in optical micrographs is a common, yet avoidable artefact, often caused by the setup of the microscope, or by inherent properties caused by the nature of the sample. In this paper, we demonstrate simple

Wick action in mature mortars with binary cements containing slag or silica fume – The relation between chloride and moisture transport properties under non-saturated conditions

Moisture and ionic transport under non-saturated condition is an important, but poorly understood transport phenomena particularly for mature systems containing supplementary cementitious materials. This paper investigates the moisture and chloride profiles of 3-year old mortars containing Portland cement (OPC), slag and silica fume (SF) after long-term (30–48 months) wick action exposure in 1.09

From AR to expertise : A user study of an augmented reality training to support expertise development

Augmented reality and sensor technologies have been analysed extensively in several domains including education and training. Although, varieties of use cases and applications exist, these studies were conducted in controlled laboratory environments. This paper reports on the first user study of augmented reality prototype developed to support students to learn from trainers in professional domain

The power of love : Towards an interdisciplinary and multi-theoretical feminist love studies

Although love in some form is arguably as old as humankind, many scholars judge that it has never been as socially and existentially decisive as it is in contemporary western societies (Bauman 2003; Beck and Beck-Gernsheim 1995; Ferry 2013; Giddens 1992; Gunnarsson 2014a; Illouz 2012; Jónasdóttir 1994, 2011; Kaufmann 2011; Luhmann 1998; May 2011). The loosening of collective and role-based modes o

Visualization of instantaneous structure and dynamics of large-scale turbulent flames stabilized by a gliding arc discharge

A burner design with integrated electrodes was used to couple a gliding arc (GA) discharge to a high-power and large-scale turbulent flame for flame stabilization. Simultaneous OH and CH2O planar laser-induced fluorescence (PLIF) and CH PLIF measurements were conducted to visualize instantaneous structures of the GA-assisted flame. Six different regions of the GA-assisted flame were resolved by th

Predicting caregiver burden in informal caregivers caring for persons with dementia living at home – A follow-up cohort study

Longitudinal studies of caregiver burden when caring for persons with dementia living at home are sparse. The aim of the study was to identify factors associated with caregiver burden and predicting increased burden related to caregivers, persons with dementia and formal care. Data were collected through interviews with 1223 caregivers in eight European countries. Bivariate and multivariate regres

Palaeoclimate constraints on the impact of 2 °C anthropogenic warming and beyond

Over the past 3.5 million years, there have been several intervals when climate conditions were warmer than during the pre-industrial Holocene. Although past intervals of warming were forced differently than future anthropogenic change, such periods can provide insights into potential future climate impacts and ecosystem feedbacks, especially over centennial-to-millennial timescales that are often

Ectomycorrhizal community composition and function in a spruce forest transitioning between nitrogen and phosphorus limitation

Nitrogen is the main limiting nutrient in boreal ecosystems, but studies in southwest Sweden suggest that certain forests approach phosphorus (P) limitation driven by nitrogen (N) deposition. We added N, P or N + P to a Norway spruce forest in this region, to push the system to N or P limitation. Tree growth and needle nutrient concentrations indicated that the trees are P limited. EMF biomass was

Single particle ignition and combustion of pulverized pine wood, wheat straw, rice husk and grape pomace

This work examines the combustion behavior of single pulverized biomass particles from ignition to early stages of char oxidation. The biomass residues investigated were pine wood, wheat straw, rice husk and grape pomace. The biomass particles, in the size range 224-250 μm, were injected upward into a confined region with hot combustion products, produced by a flat flame McKenna burner, with a mea