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Object. Cerebral vasospasm following subarachnoid hemorrhage (SAH) leads to reduced blood flow in the brain. Inspired by organ culture-induced changes in the receptor phenotype of cerebral arteries, the authors investigated possible changes in the 5-hydroxytryptamine (HT) receptor phenotype after experimental SAH. Methods. Experimental SAH was induced in rats by using an autologous prechiasmatic i
This paper discusses the ethics underlying the occupational repertoire of the post-industrial citizen, giving attention to lifestyle phenomena such as increased tempo and quantity of occupations; manipulation of time, organisms and environments; decreases in sleep, rest and play etc. In trying to understand human behavior in the 21st century, an ethical perspective is delineated and some starting
Hemopoietic stem cells (HSCs) are maintained at relative quiescence by the balance between the positive and negative regulatory factors that stimulate or inhibit their proliferation. Blocking the action of negative regulatory factors may provide a new approach for inducing HSCs into proliferation. A variety of studies have suggested that TGF-beta negatively regulates cell cycle progression of HSCs
Performance of computer-based systems may depend on many different factors, internal and external. In order to design a system to have the desired performance or to validate that the system has the required performance, the effect of the influencing factors must be known. Common methods give no or little guidance on how to vary the factors during prototyping or validation. Varying the factors in a
Background: Iceland's geographical isolation with a stable and small population gives a rare opportunity for follow-up studies of medical interventions. Total hip replacements (THR) have been done at FSA Central Hospital in Akureyri, Iceland since 1982 with the Exeter hip implant being in use from the beginning. Methods: Hospital records for all patients operated on with THR between 1982 and the e
We examine how to reliably exploit baseline diversity of a multichannel interferometric synthetic aperture radar (InSAR) system to overcome the layover problem. In practice, the baseline steering vectors will be imprecise, resulting in array miscalibration. We propose, a nonparametric multilook approach based on robust Capon beamforming (RCB), allowing for uncertainty in the steering vectors.
We followed 11 patients 3-15 years after a cemented mega total hip replacement for a proximal femoral bone tumor. 7/8 survivors had good function and only occasional pain. 1 hip had been revised because of deep infection and in 1 case the cup had been exchanged because of aseptic loosening. 2 patients had been operated on because of local recurrence of the tumor. At follow-up, 1 patient had radiog
Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and la
Background. Of the estimated one million Papanicolaou (pap) smears performed annually in Sweden, about 4% show any degree of abnormality. Approximately, 1% of these cases contain moderate or severe atypia (high-grade squamous intraepithelial lesions) and the rest contain low-grade atypia. Recommendations for the management of minor abnormalities vary in various parts of Sweden. Generally, a second
We derive stellar ages, from evolutionary tracks, and metallicities,from Strömgren photometry, for a sample of 5828 dwarf and sub-dwarfstars from the Hipparcos Catalogue. This stellar disk sample is used toinvestigate the age-metallicity diagram in the solar neighbourhood. Suchdiagrams are often used to derive a so called age-metallicity relation.Because of the size of our sample, we are able to q
In the present experiment we examined reality monitoring for socially sensitive and non-sensitive information relating to prejudice (negative and positive beliefs about an ethnic minority). At study, participants either imagined or perceived negative or positive attributes in connection with photographs of target individuals that clearly varied in ethnicity (non-western or western). At test, the t
The aim of this study is to examine the rewriting of the memoirs of the former pirate Alexander Olivier Exquemelin, Los Piratas de América, originally published in Amsterdam in 1678, which the Mexican writer Carmen Boullosa carries out in two recent novels: Son vacas, somos puercos and El médico de los piratas. In the light of Gérard Genette’s theory of hypertextuality this study deals with the fo
Surveillance of group A streptococcal (GAS) infections was undertaken as a major component of the European Commission-funded project on severe GAS disease in Europe (strep-EURO). One aim of strep-EURO was to improve the quality of GAS characterization by standardization of methods. An external quality assurance study (EQA) was therefore carried out to evaluate current global performance. Eleven st
The wobbling excitations in the presence of an appreciable amount of alignment are expected to appear more easily at lower angular momenta of the yrast spectra, compared with those in the textbook example. The large B(E2;I-->I-1) value for Delta(n) over cap =1 transitions where (n) over cap expresses the number of wobbling phonons is shown to be a strongly increasing function of the triaxiality pa
The adsorption of a single and negatively charged polyion with varying flexibility onto a surface carrying both negative and positive charges representing a charged membrane surface has been investigated by using a simple model employing Monte Carlo simulations. The polyion was represented by a sequence of negatively charged hard spheres connected with harmonic bonds. The charged surface groups we
Extremal control of Wiener type processes is considered. These modelsconsists of a linear part followed by a static nonlinearity. We will considernonlinearities having one extremum point. The purpose is tokeep the output of the process as close as possible to the extremum point.The main problem in the control of this kind of processesis the non-uniqueness of the inverseof the nonlinearity. This ca
Resurgence of microbialites and anachronistic facies in the aftermath of Phanerozoic extinction events has hitherto only been documented among the "major five." Based on the classical Silurian carbonate platform strata of Gotland, Sweden, a "minor" biotic event is herein for the first time related to a substantial increase in anachronistic facies. Strata deposited during and shortly after the Lau
Recently, common noncoding variants in the TCF7L2 gene were strongly associated with increased risk of type 2 diabetes in samples from Iceland, Denmark, and the U.S. We genotyped 13 single nucleotide polymorphisms (SNPs) across TCF7L2 in 8,310 individuals in family-based and case-control designs from Scandinavia, Poland, and the U.S. We convincingly confirmed the previous association of TCF7L2 SNP
