OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression t

Camera systems used, e.g., in cars, UAVs, smartphones, and tablets, are typically equipped with IMUs (inertial measurement units) that can measure the gravity vector. Using the information from an IMU, the y-axes of cameras can be aligned with the gravity, reducing their relative orientation to a single DOF (degree of freedom). In this paper, we use the gravity information to derive extremely effi

District heating systems make an important puzzle piece in the energy system of both today and tomorrow. When designing, simulating and controlling these systems, hydraulics play a vital role. The pressure generated by pumps has to drive sufficient flow throughout the system to satisfy the requirements of customers. Ensuring that the system is sufficiently pressurized is a challenging task already

In the present paper, strategies for reduced order modeling of geometrically nonlinear finite element models are investigated. Simulation-free, non-intrusive approaches are considered, which do not require access to the source code of a finite element program (e.g., proprietary knowledge). Our study focus on but is not restricted to flat structures. Reduction bases are generated using bending mode

Rare-earth doped nanoparticles can exhibit narrow optical and spin linewidths at low temperatures. These outstanding properties for nanomaterials make them attractive for quantum technologies based on optically addressable spins such as quantum memories and computers. Although accurate linewidth measurements have been reported using, for example, spectral hole burning or photon echo techniques, so

PURPOSE OF REVIEW: In recent years there has been increased interest in understanding the physiology and function of regulatory T cells. In this review we focus on the characterization of regulatory T-cell subsets and their potential therapeutic use in organ transplantation.RECENT FINDINGS: Regulatory T cells can play an instrumental role in the establishment of operational tolerance to allografts

Hematopoietic stem cells (HSCs) have the ability to self-renew and to give rise to all blood cells of the different lineages, and are thereby responsible for the replenishment of blood cells throughout life. These cells are tightly regulated by extrinsic and intrinsic regulators, such as signals from the bone marrow microenvironment, complex transcription factor networks and epigenetic regulators.

Industry is increasingly committed to reduce its ecological footprint. One specific area of increased industrial interest is the use of plastic-free packaging. Plastic packaging is efficient from a supply chain perspective, but as waste risks causing disastrous environmental effects. This case study assesses the environmental impacts (from cradle to grave) of plastic cushioning inserts vs. corruga