Background: The use of functional genomics has largely increased our understanding of cell biology and promises to help the development of systems biology needed to understand the complex order of events that regulates cellular differentiation in vivo. One model system clearly dependent on the integration of extra and intra cellular signals is the development of B-lymphocytes from hematopoietic st

Abstract in Undetermined A number of reforms have been implemented in Swedish health care to support integrated care for frail older people and to reduce utilization of hospital care by this group. Outcomes and process indicators have been used in pay-for-performance (P4P) schemes by both national and local governments to support developments.

To study and compare the safety of intersection, traffic scientists today typically manually monitor the intersection during several days and count how often certain events such as evasive manoeuvres occur. This is a laboursome and costly procedure. The aim of this thesis is to provide tools that can reduce the amount of manual labour required by using automated video analytics. Two methods for cr

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen bland kvinnor i Sverige. Mer än 7000 kvinnor insjuknar varje år i bröstcancer, och cirka 1500 dör i sjukdomen. Incidensen av bröstcancer har stigit kontinuerligt sedan 1970-talet, och man uppskattar att en av tio kvinnor i Sverige kommer att utveckla bröstcancer någon gång under sin livstid. Den relativa överlevnaden i sjukdomeCancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to

We present a novel visibility algorithm for rendering motion blur with per-pixel anti-aliasing. Our algorithm uses a number of line samples over a rectangular group of pixels, and together with the time dimension, a two-dimensional spatio-temporal visibility problem needs to be solved per line sample. In a coarse culling step, our algorithm first uses a bounding volume hierarchy to rapidly remove

In the Nordic countries machine strength grading of structural timber is becoming increasingly important. A new standard, EN 14081, which allows CE-marking of strength graded structural timber was recently accepted. This standard allows both machinecontrol and output control as methods for controlling the graded timber. Machine control is most commonly used in Europe. The project reported here dea

Recent studies implicated the existence of adult lymphoid-primed multipotent progenitors (LMPPs) with little or no megakaryocyte-erythroid potential, questioning common myeloid and lymphoid progenitors as obligate intermediates in hematopoietic stem cell (HSC) lineage commitment. However, the existence of LMPPs remains contentious. Herein, global and single-cell analyses revealed a hierarchical or

Radionuclide therapy is a promising modality for treatment of tumours of haematopoietic origin while the success for treatment of solid tumours so far has been limited. The authors consider radionuclide therapy mainly as a method to eradicate disseminated tumour cells and small metastases while bulky tumours and large metastases have to be treated surgically or by external radiation therapy. The p

Atomic spectroscopy plays an important role in fusion research and extensive knowledge of atomic parameters is needed for plasma diagnostics. However, a magnetically confined hot plasma can be considered as a spectroscopic fight source which has some unique properties, including high temperature and low density. Fusion devices can therefore be used to tackle problems in basic atomic physics. This

Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK

While the world's transport energy matrix is still strongly linked to limited and heavily polluting fossil fuels, new markets are appearing for the production and use of alternative transport fuels, such as liquid biofuels. Due to an interconnected global economy, such markets today are developing oil a global scale with actors looking to meet local as well as potential international demand. The a

Biochar application to soils has potential to simultaneously improve soil fertility and store carbon to aid climate change mitigation. While many studies have shown positive effects on plant yields, much less is known about the synergies between biochar and plant growth promoting microbes, such as mycorrhizal fungi. We present the first evidence that arbuscular mycorrhizal (AM) fungi can use bioch

I ett barnahus ska myndigheter samverka under ett tak vid utredningar av misstänkta brott mot barn. Samverkan ska bidra till kontinuerligt utbyte av kunskap och information i såväl enskilda ärenden som på en övergripande nivå. Men vad händer när olika professionella såsom socionomer, poliser, åklagare, rättsmedicinare och psykologer ska samverka? Hur påverkas deras arbete? Vilka svårigheter och vi