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INTRODUCTION: We sought to harmonize genotype data from the predementia AMYPAD (Amyloid Imaging to Prevent Alzheimer's Disease) Consortium, compute polygenic risk scores (PRS), and determine their association with global amyloid deposition. METHODS: Genetic data from five AMYPAD parent cohorts were harmonized, and PRS were computed for Alzheimer's disease (AD) susceptibility, cerebrospinal fluid (

Context. Tidal interactions between massive galaxies and their satellites are fundamental processes in a universe with a λ cold dark matter (λ CDM) cosmology, and they redistribute material into faint features that preserve records of past galactic interactions. While stellar streams in the Local Group impressively demonstrate satellite disruption, they do not constitute a statistically significan

Background and Aims: Perineal wound complications occur frequently after proctectomy in patients with inflammatory bowel disease (IBD), with persistent perineal wounds appearing in some patients. This study examines the surgical outcomes after proctectomy in patients with IBD in a contemporary setting, with primary perineal wound healing as the primary end-point. Methods: This is a multicentre ret

From compassion to animal liberation, health, and sustainability, veganism is a concept in flux in Taiwan as a new generation of actors are bringing a fresh face and tactics to a novel yet familiar practice. This article examines the emergence of Taiwan’s new vegan movement during the socially receptive period that followed the Sunflower Movement. It introduces the actors involved in vegan advocac

Coffee is epidemiologically linked to health benefits and risks. Coffee is thought to be a diuretic. However, it can still contribute to daily fluid intake. Vasopressin is the most important physiological regulator of body fluid balance and diuresis. This study aimed to map the effects of coffee intake on vasopressin concentration. In the population-based cross-sectional Malmö Offspring Study (n =

Mycorrhizal fungi are ecosystem engineers that sustain plant life and help regulate Earth's biogeochemical cycles1-3. However, in contrast to plants and animals, the global distribution of mycorrhizal fungal biodiversity is largely unknown, which limits our ability to monitor and protect key underground ecosystems4,5. Here we trained machine-learning algorithms on a global dataset of 25,000 geoloc

Subtle population structure remains a significant concern in genome-wide association studies. Using human height as an example, we show how quantile regression, a natural extension of linear regression, can better correct for subtle population structure due to its inherent ability to adjust for quantile-specific effects of covariates such as principal components. We utilize data from the UK Bioban

X-ray tomography is a well established technique for investigating three-dimensional bulk structures across scales, from macroscopic samples down to their microscopic constituents. The addition of a temporal dimension through dynamic, time-resolved acquisition results in four-dimensional datasets whose complexity often exceeds the processing capabilities of existing image analysis tools. To addres

Background. National registries that capture patients with chronic kidney disease (CKD) across all stages are scarce. We present here the Swedish Renal Registry (SRR), a nationwide prospective register covering the whole spectrum of CKD. Methods. Created in 1991, SRR enrolls CKD patients referred to adult nephrologist care (non-dialysis CKD [ND-CKD], kidney transplantation, maintenance dialysis),

Precapillary pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance (PVR), with progressively altered right (RV) and left ventricular (LV) hemodynamics and function. Kinetic energy (KE) from 4D flow cardiovascular magnetic resonance (CMR) is a measure of intracardiac hemodynamics. In this observational case–control study, we investigate physiological mechanisms inf

Objectives: Timely discovery and adequate patient management are crucial in non-small cell lung cancer (NSCLC) since long-term survival is only achievable in early-stage disease. In our study, we aimed to elucidate the effects of time to surgery on survival and to assess the impact of the COVID-19 pandemic on elapsed time until surgery. Methods: In total, 2536 Caucasian NSCLC patients who underwen

Phytoglobins (Pgbs) are plant hemoglobin-like proteins with key roles in nitric oxide (NO) scavenging, oxygen sensing, and hypoxic stress responses. Their typical hexacoordination results in unusually high affinities for gaseous ligands such as NO and carbon monoxide (CO), complicating measurement using conventional methods. Standard assays often require large sample volumes and lack sensitivity f

We present time-resolved three-dimensional measurements of the averaged liquid mass distribution generated by the Spray M from the Engine Combustion Network. The operating condition corresponds to a non-reacting early injection case for spray-guided gasoline injection during the first 200 μs. Few-femtosecond X-rays from a compact laser wakefield accelerator, enable quantitative spray measurements,

Differential cross-sections are measured for the production of four charged leptons in association with two jets. These measurements are sensitive to final states in which the jets are produced via the strong interaction as well as to the purely-electroweak vector boson scattering process. The analysis is performed using proton-proton collision data collected by ATLAS at s = 13 TeV and with an int

Two-dimensional terahertz spectroscopy (2DTS) is a low-frequency analog of two-dimensional optical spectroscopy that is rapidly maturing as a probe of a wide variety of condensed matter systems. However, a persistent problem with 2DTS is the long experimental acquisition times, which prevent its broader adoption. A potential solution, requiring no increase in experimental complexity, is signal rec

Balancing selection is a potentially important factor in the maintenance of genetic variation for fitness and, alongside recessive deleterious mutations, the genetic basis of inbreeding depression. Classic population genetics theory predicts that inbreeding restricts the range of conditions leading to balancing selection. For example, in models of heterozygote advantage, the classic theory shows t

I uppsatsen undersöker vi hur ett system styrt av Klein-Gordon-ekvationen beter sig under en punktpåverkan. Detta är den enklaste typen av påverkan och med hjälp av denna kunskap kan man dra slutsatser om systemets beteende för mer generalla fall av påverkan. Kvantfysiken beskriver de mest fundamentala byggstenarna av vårt universum, subatomära partiklar. Dessa är, som namnet tyder på, mindre än This paper explores the Klein-Gordon equation, a relativistic wave equation. More specifically, it studies the free form of the equation, where the potential is set to zero. The partial differential equation, together with initial conditions, forms an initial value problem. The first goal of the paper is to derive the Green's function for the problem. This is done in several ways, using spectr

The European Union's climate strategy emphasises energy democracy, encouraging citizens to participate actively in energy production and consumption as part of the transition to climate neutrality by 2050. This chapter explores the role of energy communities (ECs) in advancing energy democracy, particularly within Sweden's centralised energy system. ECs offer citizens a pathway to collective owner