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OBJECTIVES:: To evaluate the efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) in patients with Huntington's disease (HD). METHODS:: In a randomized, double-blind, placebo-controlled, 4-week trial, patients with HD received pridopidine (50 mg/d, n = 28) or placebo (n = 30). The primary outcome measure was the change from baseline in weighted cognitive score, assessed by cognit

Popular Abstract in Swedish Datorgrafik handlar om att övertyga betraktaren. En huvuduppgift är att generera verklighetstrogna bilder utifrån tredimensionella modeller. Med hjälp av datorer simuleras hur dessa modeller interagerar med ljus. Betraktaren skall helst inte reflektera över om bilden han ser är ett fotografi eller en helt och hållet genererad bild. I denna avhandling presenteras algoritModern graphics hardware pipelines create photorealistic images with high geometric complexity in real time. The quality is constantly improving and advanced techniques from feature film visual effects, such as high dynamic range images and support for higher-order surface primitives, have recently been adopted. Visual effect techniques have large computational costs and significant memory bandwid

Stroke is the third most common cause of death in developed countries, exceeded only by coronary heart disease and cancer, but there is still little knowledge on occupational risk factors. A systematic critical review was performed to assess the strength of evidence for causal associations between work-related psychosocial risk factors, shift work and stroke.

Abstract in UndeterminedRoot cause analysis (RCA) is a structured investigation of a problem to detect the causes that need to be prevented. We applied ARCA, an RCA method, to target problems of four medium-sized software companies and collected 648 causes of software engineering problems. Thereafter, we applied grounded theory to the causes to study their types and related process areas. We detec

Disease trend studies based on birth cohort analysis and serological studies indicate that recent generations have a higher prevalence of oncogenic Human Papilloma Virus (HPV) types, and are likely to be at higher risk of cancer than previous generations. This implies that prevention strategies to protect young populations from HPV-associated cancers need to be strengthened, and hence organized im

A clock-and-data precharged dynamic (CDPD) circuit technique in CMOS is presented. It gives a fast one-clock-cycle decision to multilevel logic and has small clock loads, low peak current, small area and low power-delay product. The technique is highly flexible in logic design. For the given example, a 324bit binary-lookahead-carry chain, the speed improvement can be as high as 40–50% compared to

In this paper we study (sigma,tau)-derivations on algebras from an abstract point of view. After some definitions and examples, we derive Leibniz type formulas and introduce a module structure on spaces of (sigma,tau)-derivations. Then we find all (sigma,tau)-derivations on unique factorization domains when sigma and tau are different endomorphisms. We also prove necessary equations for sigma-deri

Dynamics of commercial fish stocks are generally associated with fishing pressure and climate variability. Due to short time series, past studies of the relationships between fish stock dynamics and climate have mainly been restricted to the last few decades. Here we analyzed a century-long time series of plaice, cod and haddock from the Skagerrak-Kattegat, to assess the long-term influence of cli

Popular Abstract in English Bracings are structural components that assure the stability of the load bearing structures is maintained so as a desired level of load-carrying capacity of them is achieved. The present study as a whole involves investigations of either the temporary or permanent bracings that are often required during the construction phase of steel bridges. Current knowledge concerniA number of steel bridges have suffered lateral-torsional failure during their construction due to their lacking adequate lateral and/or rotational stiffness. In most cases, slight bracing can be of great benefit to the main girders involved through their controlling out-of-plane deformations and enabling the resistance that is needed to be achieved. The present research concerned the performance

Objective. To evaluate the effects on neonatal morbidity of a regional change in induction policy for post-term pregnancy from 43(+0) to 42(+0) gestational weeks (GWs). Design and setting. Nationwide retrospective register study between 2000 and 2007. Population. All singleton pregnancies with a gestational age of >41(+2) GW (n= 119,198). Methods. All Swedish counties were divided into three group

During the past decade, upconverting nanoparticles (UCNPs) doped with rare earth ions have become an important class of fluorescence contrast agents for molecular imaging, due to their unique properties. Their property of anti-Stokes luminescence, with both the excitation and emission wavelengths close to the optimal for biomedical imaging, has been extensively explored in various biomedical appli