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Bestämning av matrixkomponenter i ledvätska och blod – ett nytt sätt att studera broskpåverkan vid ledsjukdom.
High-accuracy localization for assisted living : 5G systems will turn multipath channels from foe to friend
Asisted living (AL) technologies, enabled by technical advances such as the advent of the Internet of Things, are increasingly gaining importance in our aging society. This article discusses the potential of future high-accuracy localization systems as a key component of AL applications. Accurate location information can be tremendously useful to realize, e.g., behavioral monitoring, fall detectio
Immunologic response to collagen-impregnated vascular grafts
Human monocyte elastolytic activity, the propeptides of types I and III procollagen, proteoglycans and interleukin 6 in synovial fluid from patients with arthritis
Serum concentrations of hyaluronan and proteoglycan in joint disease. Lack of associaton.
Connective tissue macromolecules as markers for tissue processes in joint disease.
An early event in joint disease is a progressive destruction of the articular cartilage following degradation of matrix macromolecular constituents. The fragments thus formed are released into surrounding fluids by diffusion and can be detected and quantified by immunoassay. By using assays for macromolecules/fragments specific for cartilage, it is possible to monitor processes in a given articula
Molecular markers of processes in cartilage in joint disease
Macromolecular markers in joint disease
Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions.
OBJECTIVE: To investigate whether fragmentation of proteoglycans in arthritis results in domains that have different levels of release from cartilage at different stages of the disease.METHODS: Two regions of the proteoglycan, the hyaluronan-binding region and the glycosaminoglycan-rich region of the core protein, were measured, by immunoassay, in knee joint synovial fluids of patients with rheuma
Cartilage oligomeric matrix protein. A novel marker of cartilage turnover detectable in synovial fluid and blood
Cartilage oligomeric matrix protein (COMP) is a tissue specific non-collagenous matrix protein. We have developed an enzyme-linked immunosorbent assay for the detection of this protein in synovial fluid and serum. The protein has been quantified in these fluids in patients with rheumatoid arthritis (RA), reactive arthritis, juvenile chronic arthritis, osteoarthritis and in sera of control subjects
Increased serum concentrations of cartilage oligomeric matrix protein. A prognostic marker in early rheumatoid arthritis
Markers of cartilage destruction. In Rheumatoid Arthritis. Recent Research Advances
Konsekvenser av inflammation. Effekter på brosk och ben
Release of cartilage macromolecules into the synovial fluid in patients with acute and prolonged phases of reactive arthritis
An extra cysteine in one of the non calcium binding EGF-like motifs of the FBN1 polypeptide is connected to a novel variant of Marfan syndrome
We present here a family with a clinical phenotype resembling Marfan syndrome (MFS), and displaying joint contracture and episodes of knee joint effusions, but lacking the cardiovascular features of the syndrome. The phenotype of this family represents a unique mixture of connective tissue symptoms, some of which are found in classical MFS and some of which are typical of dominant ectopia lentis.
Increased release of bone sialoprotein into synovial fluid reflects tissue destruction in rheumatoid arthritis
Objective. Bone sialoprotein (BSP) was quantified in synovial fluids and sera from rheumatoid arthritis (RA) patients to elucidate whether its release from bone relates to the degree of joint tissue destruction. Osteocalcin was assayed for comparison. Methods. BSP and osteocalcin levels were determined by immunoassays of knee synovial fluids and of sera from RA patients who were selected on the
Cartilage and bone metabolism in rheumatoid arthritis: Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism
Serum concentrations of two cartilage matrix proteins reflecting different aspects of cartilage turnover in relapsing polychondritis
Matrix proteins: Potentials as body fluid markers of changes in the metabolism of cartilage and bone in arthritis
Altered dynamics of cartilage and bone matrix in joint diseases results in increased release of macromolecules into synovial fluid (SF). Such macromolecules are increasingly explored as potential markers of damage and severity. This report focuses on the possibilities of using quantification of tissue specific markers for grading the tissue lesion at the molecular level in arthritis. The theoretic