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OBJECTIVE: To evaluate speech in 5-year-olds with cleft palate with or without cleft lip (CP±L) treated with primary palatal surgery in 1 stage with muscle reconstruction according to Sommerlad at about 12 months of age.DESIGN: Retrospective study.SETTING: Primary care university hospital.PARTICIPANTS: Eight 5-year-olds with cleft soft palate (SP), 22 with cleft soft/hard palate (SHP), 33 with uni

Background: Admission lactate and lactate clearance are implemented for risk stratification in sepsis and trauma. In out-of-hospital cardiac arrest, results regarding outcome and lactate are conflicting. Methods: This is a post-hoc analysis of the Target Temperature Management trial in which 950 unconscious patents after out-of-hospital cardiac arrest were randomized to a temperature intervention

This study re-examines standard econometric approaches for detecting adverse and advantageous selection in insurance contracts based on variables that are not used for calculating the insurance premium. We formally demonstrate that existing strategies for detecting selection based on such ‘unused characteristics’ can lead to incorrect conclusions if the estimated coefficients of interest are drive

We propose and analyze distributed computation algorithms for finite-horizon optimal control problems in transportation networks. We model traffic flow dynamics by the cell-transmission model and focus on two problems: system-optimum dynamic traffic assignment (where the routing is part of the optimization) and freeway network control (where the routing is exogenous and the optimization is confine

Magmatism of the Povungnituk Group of the Cape Smith Belt, northern Superior craton, was formed in three stages: (i)early alkaline magmatism and associated carbonatites (undated), (ii) a main flood basalt sequence (Beauparlant Formation) (constrained between 2040 and 1991 Ma), and (iii) a late stage alkaline pulse (Cecilia Formation) (ca. 1959 Ma). We suggest that the main stage of magmatic activi

Measurement of biosphere-atmosphere exchange of various greenhouse gases requires different techniques. In case of carbon dioxide, the net ecosystem exchange (NEE) is usually measured by the eddy covariance method. In the lack of these measurements in forests, the carbon dioxide uptake can be estimated by detecting changes in sequestrated carbon stocks or by using tree growth (dendrometric) measur

The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association with outcome after detection of disease recurrence. Consecutive patients with nonmetastatic RCC (n = 1612) treated with curative intent at 12 institutes across eight European

Gösta Werner (1908–2009) var en svensk filmpionjär som i rollen som redaktör, regissör och forskare gjorde starkt avtryck på den offentliga debatten om filmen som konstform. Genom att studera denna framträdande filmpersonlighets texter och filmer belyser avhandlingen ett antal viktiga kulturpolitiska strider inom den framväxande svenska konstfilmsinstitutionen, däribland om filmstudiets formering,

The seasonal phenology of the leaf area index (LAI) is a major determinant of net ecosystem production in deciduous forest ecosystems. This study describes seasonal and inter-annual differences in LAI in a boreal aspen-hazelnut forest in central Saskatchewan, Canada, between 1994 and 2003, and relates the differences in LAI to annual net ecosystem production (FNEP). A robust method is developed to

Three different, state-of-the-art biogeochemical models are adapted in order to quantify the carbon dioxide (CO2), nitrous oxide (N 2O), and methane (CH4) exchanges between arable lands and the atmosphere. Biome-BGC and MOD17 are validated using the long-term measurement results from Hegyhátsál tall tower site (Western Hungary). After a simple bias correction, it was found that Biome-BGC is capabl

Background: Oxygen is liberally administered in intensive care units (ICUs). Nevertheless, ICU doctors’ preferences for supplementing oxygen are inadequately described. The aim was to identify ICU doctors’ preferences for arterial oxygenation levels in mechanically ventilated adult ICU patients. Methods: In April to August 2016, an online multiple-choice 17-part-questionnaire was distributed to 10

OBJECTIVES: To evaluate knowledge translation after publication of the target temperature management 33°C versus 36°C after out-of-hospital cardiac arrest trial and associated patient outcomes. Our primary hypothesis was that target temperature management at 36°C was rapidly adopted in Australian and New Zealand ICUs. Secondary hypotheses were that temporal reductions in mortality would be seen an

Objectives: The authors sought to compare reclassification of treatment strategy following instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR). Background: iFR was noninferior to FFR in 2 large randomized controlled trials in guiding coronary revascularization. Reclassification of treatment strategy by FFR is well-studied, but similar reports on iFR are lacking. Methods: The iFR-

Background: In the Swedish population aged between 50 and 64 years only 7.1% reach the recommended level of physical activity. Physical activity on prescription (PAP) has been used in Sweden since the beginning of the twenty-first century with moderate adherence of approximately 50%. Mindfulness seems to affect motivation to and satisfaction with physical activity. The aim is to test the feasibili

Small cell lung cancer (SCLC) is a neuroendocrine tumour that exhibits rapid growth and metastatic spread. Although SCLC represents a prototypically undifferentiated cancer type, thyroid transcription factor-1 (TTF-1, gene symbol NKX2-1), a master regulator for pulmonary epithelial cell differentiation and lung morphogenesis, is strongly upregulated in this aggressive cancer type. The aim of this

TomoWarp2 is a Python based code that allows full-field vector displacements to be measured between 2D or 3D image sets, based on a local approach of Digital Image Correlation. These displacements can be used to calculate the complete 2D or 3D strain tensor field to study, for example, heterogeneous deformation responses of materials during loading. The code is provided with a GUI, and can handle

Background: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Purpose: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of men

Objective: We endeavored to create a comprehensive course in global surgery involving multinational exchange. Design: The course involved 2 weeks of didactics, 2 weeks of clinical rotations in a low-resource setting and 1 week for a capstone project. We evaluated our success through knowledge tests, surveys of the students, and surveys of our Zimbabwean hosts. Setting: The didactic portions were h