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Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural cavity of asbestos-exposed individuals and rapidly leads to death. MPM harbors loss-of-function mutations in BAP1, NF2, CDKN2A, and TP53, but isolated deletion of these genes alone in mice does not cause MPM and mouse models of the disease are sparse. Here, we show that a proportion of human MPM harbor point muta
The concept of evolvability - the capacity of a population to produce and maintain evolutionarily relevant variation - has become increasingly prominent in evolutionary biology. Paleontology has a long history of investigating questions of evolvability, but paleontological thinking has tended to neglect recent discussions, because many tools used in the current evolvability literature are challeng
Widowhood involves many practical challenges next to the emotional impact of bereavement. Remarriage to a blood relative of a deceased spouse can often help a bereaved spouse to solve issues related to inheritance, child care, and comfort in a stressful period. A study of 15,540 widowers and 18,837 widows in the Dutch province of Zeeland—of whom about 8,000 men and 5,000 women eventually remarried
Om de fyra kvinnliga cykelpionjärern Nanny Palmkvist, Tillie Anderson, Annie "Londoderry" Cohen Kopchovsky, Frances Willard.
An issue in sports contexts as well as other educational contexts has been whether feedback on the personal level, often in the shape of praise, contributes to the progression of the practitioners’ skills. This article examines whether PEH teachers’ feedback on the personal level, using the word good, in specific contexts actually can contribute to crucial progress and empowerment of the pupils/pr
