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Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decrease risk of type 2 diabetes (T2D). We investigate protein-altering variants in ANGPTL4 among 58,124 participants in the DiscovEHR human genetics s

A search for supersymmetry involving the pair production of gluinos decaying via third-generation squarks into the lightest neutralino (χ˜10) is reported. It uses LHC proton-proton collision data at a centre-of-mass energy s=13 TeV with an integrated luminosity of 36.1 fb−1 collected with the ATLAS detector in 2015 and 2016. The search is performed in events containing large missing transverse mom

PURPOSE OF REVIEW: To assess current pharmacological principles used for treatment of nocturia/nocturnal polyuria.RECENT FINDINGS: The pathophysiology of nocturia is often multifactorial, but two main mechanisms have been identified, occurring alone or in combination: low functional bladder capacity and nocturnal polyuria. The multifactorial pathophysiology not only implies several possible target

Due to variations in amount and distribution of glandular breast tissue among women, the mean glandular dose (MGD) can be a poor measure of the individual glandular dose. Therefore, to improve the basis for risk assessment related to radiation dose from breast X-ray examinations, the distribution should be considered. Breast tomosynthesis (BT) is an imaging technique that may be used as an alterna

This contribution consists of a multi-flow rate optimization method to maximize the key performance indicators, yield, degree of resin utilization and productivity for a chromatographic loading step. The protein adsorption to the resin is modeled using a mechanistic column model with a steric mass action adsorption isotherm. The model was used to optimize the flow rate trajectories and the loading

In this article, the theological meaning of transformation is examined from the vantage point of a local Pentecostal church in Nairobi, Kenya, and its liturgical practices. The church under study is the Woodley branch of Christ is the Answer Ministries (CITAM Woodley), formerly Nairobi Pentecostal Church (NPC) Woodley, and data was collected through field research. Arguing with the help of Steven

Two different learning models for a teachable agent were tested with respect to perceived intelligence, the protégé effect, and learning in Swedish grade 5 and 6 students. A strong positive correlation was found between perceived intelligence and the protégé effect, but no significant differences were found between the two different implementations of the learning algorithm. The results suggest th

The popularity of faith-healing in sub-Saharan Africa has been widely acknowledged in research, but mostly treated as a phenomenon apart, instead of being viewed in relation to other modes of healing. In this article I focus on the reasons why believers choose faith-healing in a medically pluralistic situation and how they see other healing options available in a locally founded Charismatic church

For learning to take place in digital learning environments, learners need to use educational software – more or less – as intended. However, previous studies show that some school children, instead of trying to learn and master a skill, choose to systematically exploit or outsmart the system to gain progress. But what about preschoolers? The present study explores the presence of this kind of beh

Background: The absence of interleukin-25 (IL-25) favors the induction of Th1 and Th17 immune responses in mice. Th1 immune responses have been associated with the pathology of atherosclerosis, a lipid and inflammation driven disease of the arterial wall. Purpose of research: To evaluate the effect of IL-25 on human peripheral blood mononuclear cells (hPBMCs) in the presence and absence of oxidize

Antimicrobial stewardship programmes including a multidisciplinary team of urologists, infectious disease specialists, and microbiologists reduce the total use of antibiotics in urological care without jeopardising the patient outcome. It is a recommended tool for education and feedback.

In the predominantly Muslim context of Zanzibar, Pentecostal Christianity is slowly on the rise as a result of an influx of labor migrants from mainland Tanzania. A paramount feature in these churches is the provision of divine healing and deliverance from spiritual affliction. This article analyses how narratives of healing in one of Zanzibar's major Pentecostal churches, the City Christian Cente

We report on an experimental demonstration of spatially-resolved detection of atomic hydrogen in flames using a single-ended configuration. The lasing signal in a backward direction is obtained by two-photon pumping with 205-nm femtosecond laser pulses.

Objective: Recent research has shown that combining radiotherapy and immunotherapy can counteract the ability of cancer to evade and suppress the native immune system. To optimise the synergy of the combined therapies, factors such as radiation dose and fractionation must be considered, alongside numerous parameters resulting from the complexity of cancer-immune system interactions. It is instruct

In a study with 108 10- to 12-year-olds who used a digital educational game targeting history, we addressed the phenomenon of perseverance, that is, the tendency to stick with a task even when it is challenging. The educational game was designed to make all students encounter tasks they did not succeed to solve, at which point they were offered a set of choices corresponding to perseverance and no

With the emergence of industrial IoT and cloud computing, and the advent of 5G and edge clouds, there are ambitious expectations on elasticity, economies of scale, and fast time to market for demanding use cases in the next generation of ICT networks. Responsiveness and reliability of wireless communication links and services in the cloud are set to improve significantly as the concept of edge clo

Looking at two historical romances by women writers, Kathleen Graves’ Exile: A Tale of Old Tasmania (1945) and Isabel Dick’s Wild Orchard (1946), this article seeks to examine narratives of an early nineteenth-century Van Diemen’s Land that are apparently at odds with the 1940s Tasmania it was to become. Drawing on Giorgio Agamben’s “state of exception” as the theoretical underpinnings for this es

Om Henry Rinnan och hans liga.

This article addresses domestic civil society organisations (CSOs) and their multilevel strategies for gaining political influence in the European Union. Drawing on a theoretical framework identifying different 'routes' that CSOs can take in a multilevel system of EU governance, this article analyses which routes or combination of routes CSOs take and investigates what organisational factors can e