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Segmental podocytic excretory glands in the thorax of Hutchinsoniella macracantha (Cephalocarida).

All thoracic limbs of Hutchinsoniella except for the ninth contain entirely of podocytes. At the periphery of the gland, each podocyte with the investing basal lamina; centrally, there is no conspicuous podocytes, either in compact glands or in a more diffuse arrangement, decapods, mysids, and isopods, and perhaps occur in other crustaceans known to filter hemolymph and to pinocytotically extract

A critical analysis of international standards for construction classification - results from the development of a new Swedish construction classification system

A new Swedish construction classification system, CoClass, is now under development. CoClass has presented two alternative classifications for review, both based on the standard for construction classification ISO 12006-2:2015. One alternative also applies the IEC CD 81346-series for reference designations which includes classification tables for systems and components with function as the basis f

A GPS-Based Methodology to Analyze Environment-Health Associations at the Trip Level : Case-Crossover Analyses of Built Environments and Walking

Environmental health studies have examined associations between context and health with individuals as statistical units. However, investigators have been unable to investigate momentary exposures, and such studies are often vulnerable to confounding from, for example, individual-level preferences. We present a Global Positioning System (GPS)-based methodology for segmenting individuals' observati

Land-use choices follow profitability at the expense of ecological functions in Indonesian smallholder landscapes

Smallholder-dominated agricultural mosaic landscapes are highlighted as model production systems that deliver both economic and ecological goods in tropical agricultural landscapes, but trade-offs underlying current land-use dynamics are poorly known. Here, using the most comprehensive quantification of land-use change and associated bundles of ecosystem functions, services and economic benefits t

Coordinated integrin activation by actin-dependent force during T-cell migration

For a cell to move forward it must convert chemical energy into mechanical propulsion. Force produced by actin polymerization can generate traction across the plasma membrane by transmission through integrins to their ligands. However, the role this force plays in integrin activation is unknown. Here we show that integrin activity and cytoskeletal dynamics are reciprocally linked, where actin-depe

Reflecting on Social Influence in Networks

In many social contexts, social influence seems to be inescapable: the behavior of others influences us to modify ours, and vice-versa. However, social psychology is full of examples of phenomena where individuals experience a discrepancy between their public behavior and their private opinion. This raises two central questions. First, how does an individual reason about the behavior of others and

Exposing the exposures responsible for type 2 diabetes and obesity

The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced througho

Sorting cells by their dynamical properties

Recent advances in cell sorting aim at the development of novel methods that are sensitive to various mechanical properties of cells. Microfluidic technologies have a great potential for cell sorting; however, the design of many micro-devices is based on theories developed for rigid spherical particles with size as a separation parameter. Clearly, most bioparticles are non-spherical and deformable

Baltoscandian margin, Sveconorwegian crust lost by subduction during Caledonian collisional orogeny

Underthrusting of Laurentia by the continental margin of Baltica during Caledonian orogeny resulted in the lateral emplacement of Iapetus Ocean-related terranes of the Upper Allochthon at least 500 km onto Baltica. The underlying Lower and Middle allochthons of the Baltoscandian margin mostly comprise Cryogenian, Ediacaran and Cambro-Silurian sedimentary successions; basement to these formations a

Allotwinning and OD-structures-the example of malonamide

Allotwinning, the ordered intergrowth of two different structures may often be seen as a special case of OD-structures. The same structural ambiguity that allows for locally identical but globally different components of an allotwin may also allow the formation of an OD structure. When this is the case, the components of the allotwin often correspond to the MDO-structures of OD theory. Starting fr

Finite element study of the acetabulum in cemented hip arthroplasty investigating retention or removal of the subchondral bone plate

The importance of the subchondral bone plate of the acetabulum when preparing the pelvis for a cemented acetabular cup during total hip arthroplasty (THA) has been investigated using finite element analysis. The effect of retaining or removing the subchondral bone plate and the use of anchoring holes are compared. Loading was applied via both hip joint contact force and the activity of up to 22 mu

Grey and white matter clinico-anatomical correlates of disinhibition in neurodegenerative disease

Disinhibition is an important symptom in neurodegenerative diseases. However, the clinico- anatomical underpinnings remain controversial. We explored the anatomical correlates of disinhibition in neurodegenerative disease using the perspective of grey and white matter imaging. Disinhibition was assessed with a neuropsychological test and a caregiver information- based clinical rating scale in 21 p

Maturation of the intestinal epithelial barrier in neonatal rats coincides with decreased FcRn expression, replacement of vacuolated enterocytes and changed Blimp-1 expression

Background: The intestinal barrier is immature in newborn mammals allowing for transfer of bioactive macromolecules, e.g. protecting antibodies, from mother's milk to the blood circulation and in neonatal rodents lasts until weaning. This passage involves the neonatal-Fc-receptor (FcRn) binding IgG in the proximal and highly endocytic vacuolated enterocytes in the distal immature small intestine (

Influence of chloride and moisture content on steel rebar corrosion in concrete

Reinforced mortar samples were exposed in humidity chambers with different relative humidity or exposed in cyclic moisture conditions. The rebars were in an “as received” condition meaning that the preexisting oxide scale were intact. The lowest chloride concentration that initiated corrosion was 1% Cl− by mass of cement, corrosion was then observed for samples exposed at 97% relative humidity. It

Innate immune responses after airway epithelial stimulation with Mycobacterium bovis Bacille-Calmette Guérin

Mycobacterium bovis bacilli Calmette-Guerin (BCG) is used as a benchmark to compare the immunogenicity of new vaccines against tuberculosis. This live vaccine is administered intradermal, but several new studies show that changing the route to mucosal immunisation represents an improved strategy. We analysed the immunomodulatory functions of BCG on human neutrophils and primary airway epithelial c

Depressive symptoms associated with concerns about falling in Parkinson's disease

Background: Concerns about falling, a construct related to fear of falling, is increased in people with Parkinson's disease (PD) and is recognized as a barrier for exercise, negatively affecting health-related quality of life and participation. Aim: To investigate modifiable factors associated with concerns about falling in elderly with mild-to-moderate PD. Methods: Eighty-nine elderly (39 females

Forskarhandledning i teori och praktik

Detta är en efterlängtad bok som bidrar till utveckling av forskarhandledares kompetens och ger ett fördjupat perspektiv på doktoranders lärande. Med förankring i aktuell forskning behandlar författarna forskarutbildningens organisation, handledarens professionella praktik, doktorandens lärande samt utbildningens kvalitetssystem. Kopplingen mellan teori och praktik utgör en röd tråd genom boken.

Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD

Background: Peptidyl-prolyl isomerases (PPIases) catalyze cis/trans isomerization of peptidyl-prolyl bonds, which is often rate-limiting for protein folding. SlyD is a two-domain enzyme containing both a PPIase FK506-binding protein (FKBP) domain and an insert-in-flap (IF) chaperone domain. To date, the interactions of these domains with unfolded proteins have remained rather obscure, with structu