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The risk and burden of vertebral fractures in Sweden

The aim of this study was to determine the risk and burden of vertebral fractures judged as those coming to clinical attention and as morphometric fractures. Incidence and utility loss were computed from data from Malmo, Sweden. Clinical fractures accounted for 23% of all vertebral deformities in women and for 42% in men. The average 10-year fracture probability for morphometric fractures increase

Snowmelt sensitivity to radiation in the urban environment

Despite having the same snowmelt processes, snowpacks in urban environments experience a range of conditions different from those of rural areas. Melt is intensified at some sites due to greater radiative energy. Shading, however, can reduce radiation and melt at other sites. Changes to the radiation balance and snowpack processes have been investigated. A physical snowpack model was developed and

Compact archaeal variant of heme A synthase

The N- and C-terminal halves of the heme A synthase polypeptide of Bacillus subtilis, and many other organisms, are homologous. This indicates that these enzyme proteins originate from a tandem duplication and fusion event of a gene encoding a protein half as large. The ape1694 gene of the hyperthermophilic archaeon Aeropyrum pernix encodes a protein that is similar to the hypothetical small primo

Development of biosensors based on hexacyanoferrates.

Ferric and copper hexacyanoferrates (PB and CuHCF, respectively) were electrodeposited on glassy carbon electrodes providing a suitable catalytic surface for the amperometric detection of hydrogen peroxide. Additionally glucose oxidase was immobilized on top of these electrodes to form glucose biosensors. The biosensors were made by casting glucose oxidase-Nafion layers onto the surface of the mod

Proliferative index obtained by DNA image cytometry. Does it add prognostic information in Auer IV breast cancer?

OBJECTIVE: To investigate whether the S + G2/M fraction (proliferative index) is a prognostic determinant in breast cancers classified as Auer IV. STUDY DESIGN: Prognostic evaluation of Auer IV DNA histograms with respect to the high versus low S + G2/M fraction, obtained by image cytometry on consecutive breast cancer imprint preparations. RESULTS: When studying recurrence-free survival (n = 136)

The restricted active space (RAS) state interaction approach with spin-orbit coupling

A method to compute spin-orbit coupling between electronic states is presented. An effective one-electron spin-orbit Hamiltonian is used, based on atomic mean field integrals, The basic electronic states are obtained using the restricted active space (RAS) SCF method. The Hamiltonian matrix is obtained by an extension of the restricted active space state interaction (RASSI) method. Several hundred

Localization of phosphatidylinositol 4-kinase isoenzymes in rat liver plasma membrane domains

The presence of different isoenzymes of phosphatidylinositol 4-kinase in isolated rat liver plasma membranes and their further distribution in plasma membrane domains was examined. Both wortmannin-sensitive and -insensitive PtdIns 4-kinase activities were detected in highly purified plasma membranes obtained by aqueous two-phase affinity partitioning. The wortmannin-sensitive enzyme was identified

Protein kinase A-dependent activation of PDE4 (cAMP-specific cyclic nucleotide phosphodiesterase) in cultured bovine vascular smooth muscle cells

Incubation of cultured bovine vascular smooth muscle cells (VSMC) with forskolin increased cAMP as measured by an increase in cAMP-dependent protein kinase (PKA) activation (PKA ratio). Forskolin also produced a concentration- and time-dependent increase in activity (3-5-fold within 15 min) of a PDE4 (cAMP-specific cyclic nucleotide phosphodiesterase). The increase in PDE4 activity was not affecte

Altered inactivation pathway of factor Va by activated protein C in the presence of heparin

Inactivation of factor Va (FVa) by activated protein C (APC) is a predominant mechanism in the down-regulation of thrombin generation. In normal FVa, APC-mediated inactivation occurs after cleavage at Arg306 (with corresponding rate constant k'(306)) or after cleavage at Arg506 (k(506)) and subsequent cleavage at Arg306 (k(306)). We have studied the influence of heparin on APC-catalyzed FVa inacti

Reduced aortic wall stress in diabetes mellitus

Objective. Most risk factors are similar for abdominal aortic aneurysm (AAA) and atherosclerosis, e.g. smoking, male gender, age, high blood pressure, hyperlipidemia. Diabetes mellitus however, is a risk factor for atherosclerosis, but diabetic patients seldom develop AAA. The reason for this discrepancy is unknown. Increased aortic wall stress seems to be all etiologic factor in the formation, gr

Landau level structures and semimetal-semiconductor transition in strained InAs/GaSb quantum wells

Using Burt's envelope function theory and the scattering matrix method, we investigate the hybridized electron-hole Landau levels in strained InAs/GaSb quantum wells sandwiched between wide-gap AlSb barrier layers under electric and a quantizing magnetic fields applied perpendicular to interfaces. At zero magnetic field, in the structures studied here, the lowest electron level in the InAs layer l

Normal coronary flow reserve after arterial switch operation for transposition of the great arteries: an intracoronary Doppler guidewire study.

BACKGROUND: Recent studies performed with positron emission tomography have suggested that coronary flow reserve (CFR) is moderately to severely reduced after the arterial switch operation (ASO). These findings are of great concern but have not been confirmed by other methods. METHODS AND RESULTS: Eleven symptom-free children were studied between 4 and 11 (median 6.0) years after the ASO. Flow vel

A longitudinal cohort study on the prevalence of Helicobacter pylori antibodies in Swedish children and adolescents.

The aim of this study was to monitor the Helicobacter pylori antibody seroprevalence of an asymptomatic cohort between the ages of 4 and 18 y. The H. pylori antibody titres in a longitudinally followed cohort of 168 native Swedish children (born between 1972 and 1974) were established at 4, 8, 12, 16, and 18 y of age. Seventeen children (10.1%) were found positive on at least one occasion when a p