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Cell density dependent uptake of chylomicron remnants in rat hepatocyte monolaayers. Effects of compactin and mevalonic acid.

In rat hepatocytes cultured in lipoprotein-deficient serum, the uptake and degradation of chylomicron remnant cholesteryl ester per mg cell protein varies inversely with cell density. Compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, stimulates the uptake at all cell densities. Mevalonic acid, on the other hand, can suppress a significant part of the remnant up

Cell density dependent uptake of LDL in cultured hepatocytes

An inverse relationship between low-density lipoprotein uptake and cell density was observed in rat hepatocyte monolayers incubated with lipoprotein-deficient serum. This was also true for cell association, binding and degradation of low-density lipoproteins. Compactin stimulated cell association and degradation of low-density lipoproteins both at low and high concentrations. Insulin, on the other

Unwitting Wrongdoers and the Role of Moral Disagreement in Blame

This chapter argues against the claim that morally ignorant wrongdoers are open to blame only if they are culpable for their ignorance, and argues against a version of skepticism about moral responsibility that depends on this claim being true. On the view defended, the attitudes involved in blame are typically responses to the features of an action that make it objectionable or unjustifiable from